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Nonsense-Mediated mRNA Decay Mutation in Aspergillus nidulans
... of nonsense-mediated decay (NMD), whereby an mRNA containing a premature translation termination codon resulting from a frameshift or “nonsense” mutation is preferentially ... See full document
115
Antisense suppression of the nonsense mediated decay factor Upf3b as a potential treatment for diseases caused by nonsense mutations
... Upf3b-GalNAc-ASO mediated NMD ...ASO- mediated depletion of Upf3b in mouse liver induced very few changes to the normal transcriptome compared to the depletion of the robust NMD regulator ... See full document
165
smg-7 Is Required for mRNA Surveillance in Caenorhabditis elegans
... “nonsense-mediated mRNA decay” (NMD) or “mRNA ...Whereas nonsense mutant mRNAs are unstable in smg(1 ) genetic backgrounds, such mRNAs have normal stability in smg(2 ) ... See full document
437
Nonsense mediated mRNA decay affects nonsense transcript levels and governs response of cystic fibrosis patients to gentamicin
... (CFTR) nonsense transcripts is markedly reduced, while in others it is significantly ...the nonsense-mediated mRNA decay (NMD) might vary among cells and hence governs the level of ... See full document
78
A Role for the Nonsense-Mediated mRNA Decay Pathway in Maintaining Genome Stability in Caenorhabditis elegans
... mediating nonsense-mediated mRNA decay (NMD) of transcripts containing premature stop codons and related to the ATM and ATR kinases which are at the apex of DNA damage signaling ... See full document
10
Noisy splicing, more than expression regulation, explains why some exons are subject to nonsense-mediated mRNA decay
... putative nonsense-mediated decay targets in humans and ...to nonsense-mediated decay, and that the premature termination codon reflects neither rare mutations nor sequencing ... See full document
149
Novel mutations of RPGR in Chinese families with X-linked retinitis pigmentosa
... an mRNA, leading to the premature termination of transla- tion and the formation of an incomplete polypeptide ...sense mutation before the termination codons may lead to nonsense-mediated ... See full document
105
The Human T-Lymphotropic Virus Type 1 Tax Protein Inhibits Nonsense-Mediated mRNA Decay by Interacting with INT6/EIF3E and UPF1
... Displacement of INT6 from UPF1 by Tax binding. In the same experiment, it was also observed that Tax expression de- creased the amount of INT6 immunoprecipitated by UPF1 and UPF2, suggesting that Tax prevents the ... See full document
95
Premature termination codons in PRPF31 cause retinitis pigmentosa via haploinsufficiency due to nonsense mediated mRNA decay
... Blocking nonsense-mediated mRNA decay significantly restored the amount of mutant PRPF31 mRNA but did not restore the synthesis of mutant proteins, even in conjunction with inhibitors ... See full document
80
Nuclear Import of Upf3p Is Mediated by Importin-α/-β and Export to the Cytoplasm Is Required for a Functional Nonsense-Mediated mRNA Decay Pathway in Yeast
... for nonsense-mediated mRNA decay (NMD) in yeast, is primarily cytoplasmic but accumulates inside the nucleus when UPF3 is overexpressed or when upf 3 mutations prevent nuclear ...is ... See full document
100
Killing the messenger: new insights into nonsense mediated mRNA decay
... the nonsense codon–containing mRNAs, the existence of efficient NMD in eukaryotic cells is a matter of con- siderable importance in the analysis of naturally occur- ring ...a mutation search encodes a ... See full document
12
Synthesis and activity of a novel inhibitor of nonsense-mediated mRNA decay
... Inhibiting NMD is a promising approach towards treating diseases caused by PTC mutations as, in many cases, the trun- cated protein that would result if the PTC-containing mRNA were to be translated could be at ... See full document
15
The nonsense mediated RNA decay pathway is disrupted in inflammatory myofibroblastic tumors
... UPF1 exon 10 and intron 10 are unusually short (169 and 85 nt, respectively) and have a high GC content (59% and 73%, respec- tively), both of which are features that can weaken RNA splicing (6). This raised the ... See full document
154
Assessing the activity of nonsense-mediated mRNA decay in lung cancer
... total mRNA expression of NMD tar- get genes or the mRNA isoforms derived from alterna- tive splicing or nonsense mutation alleles to monitor NMD ... See full document
8
NMD inhibition fails to identify tumour suppressor genes in microsatellite stable gastric cancer cell lines
... the mRNA tran- scripts of the putative candidate genes, we did not detect nonsense ...no nonsense mutations were found in this study, we did detect silent or missense mutations in three ...silent ... See full document
13
A CIS-DOMINANT MUTATION IN ASPERGILLUS NIDULANS AFFECTING THE EXPRESSION OF THE amdS GENE IN THE PRESENCE OF MUTATIONS IN THE UNLINKED GENE, amdA
... A CIS-DOMINANT MUTATION IN ASPERGILLUS NIDULANS AFFECTING THE EXPRESSION OF THE amdS GENE IN THE PRESENCE O F MUTATIONS IN THE UNLINKED GENE, amdA.. MICHAEL J.[r] ... See full document
182
Control of gene expression through the nonsense-mediated RNA decay pathway
... in mRNA isoforms but can also lead to formation of PTCs that target transcripts for ...own mRNA, leading to NMD of the transcript ...generate mRNA isoforms with a stop codon upstream of a splice ... See full document
22
Viral Evasion and Manipulation of Host RNA Quality Control Pathways
... distinct decay pathways induced by stalled ribosomes, namely, no-go decay (NGD), which acts on mRNAs that have been damaged, that are highly structured, or that contain strings of rare codons, and non-stop ... See full document
19
Rapid Differentiation of Aspergillus Species from Other Medically Important Opportunistic Molds and Yeasts by PCR Enzyme Immunoassay
... other Aspergillus species not yet tested in the PCR-EIA probe matrix that will cross-react with our probes or whether other genes or other rDNA regions may give better discrimi- nation among the less common ... See full document
10
Multiple Nonsense-Mediated mRNA Processes Require Smg5 in Drosophila
... the cell (Gatfield et al. 2003; Rehwinkel et al. 2005). The molecular identities and biochemical characterization of the individual NMD genes have revealed clues about their roles in the NMD pathway. Upf1 is an ... See full document
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