[PDF] Top 20 La autonomía del paciente desde una perspectiva bioética.
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Drug delivery strategies to enhance the permeability of the blood–brain barrier for treatment of glioma
... improving drug delivery across the BBB, considering the failure of effec- tive treatments to cure the invasive glioma cells, which are shielded by the ...with glioma will remain dismal until ... See full document
12
Image-guided chemotherapy with specifically tuned blood brain barrier permeability in glioma margins
... the brain delivery of drugs by maximally preserving their pharmacological ...and brain edema ...facilitate brain drug delivery by disrupting TJs via bubble oscillation-induced ... See full document
103
Strategies for enhanced drug delivery to the central nervous system
... The brain is a delicate organ. The brain-microvascular endothelial cells of the blood-brain barrier protect this organ from exogenous ...the brain from the periphery of compounds ... See full document
16
Peptide gH625 enters into neuron and astrocyte cell lines and crosses the blood–brain barrier in rats
... the blood–brain barrier ...the brain was ...the brain or the mitochondrial respiration ...for drug delivery to the central nervous ...direct delivery of drugs into ... See full document
7
Acoustic feedback enables safe and reliable carboplatin delivery across the blood-brain barrier with a clinical focused ultrasound system and improves survival in a rat glioma model
... ineffective treatment of infiltrating tumor cells, and therefore subsequent ...alternative delivery methods to enhance delivery of carboplatin to infiltrating glioma including ... See full document
23
Quantification of transient increase of the blood–brain barrier permeability to macromolecules by optimized focused ultrasound combined with microbubbles
... the treatment of many malignant cancers, with reduced side ...the blood–brain barrier (BBB) inhibits the transport of intravenous antibodies to tumors in the ...the drug delivery ... See full document
5
Getting into the brain: liposome-based strategies for effective drug delivery across the blood–brain barrier
... One of the most challenging problems in therapy of gliomas is their detection in the earliest stages of development. Like many tumor types, early detection correlates with success- ful therapy. Therefore, both new ... See full document
10
Efficiency of drug delivery enhanced by acoustic pressure during blood–brain barrier disruption induced by focused ultrasound
... Materials and methods: Male Sprague-Dawley rats were injected intravenously with Evans blue (EB) before or after BBB-D induction by pulsed FUS. We used a 1.0 MHz pulsed FUS with four acoustic power settings and an ... See full document
10
Delivery of a peptide-drug conjugate targeting the blood brain barrier improved the efficacy of paclitaxel against glioma
... the brain has created an entire field of active research devoted to overcoming the blood brain barrier (BBB) and efficiently delivering drugs to the ...the brain capillary endothelial ... See full document
6
A dual-mediated liposomal drug delivery system targeting the brain: rational construction, integrity evaluation across the blood–brain barrier, and the transporting mechanism to glioma cells
... the blood, TF with a longer PEG chain could mask the nonspecificity of ...chains enhance TF binding with the ...to enhance cellular uptake through the electrostatic ... See full document
5
<p>Overcoming the Blood–Brain Barrier: Successes and Challenges in Developing Nanoparticle-Mediated Drug Delivery Systems for the Treatment of Brain Tumours</p>
... However, high-grade gliomas rapidly in fi ltrate the sur- rounding healthy tissue, where the BBB is not altered and the EPR effect cannot be achieved. 46 Indeed, in human patients, contrarily to animal tumour models, che- ... See full document
16
Blood-brain barrier permeability and physical exercise
... Exercise reduces the expression of Toll-like receptors at the surface of monocytes; these receptors have been impli- cated as mediators of systemic inflammation [180]. Muscle function, inflammation and exercise are hence ... See full document
13
<p>The relationship between blood–brain barrier permeability and enlarged perivascular spaces: a cross-sectional study</p>
... selective barrier structure com- posed of basement membrane, capillary endothelial cells, tight junctions (TJs), pericytes and ...BBB permeability also affects endothelial function, 27 which is closely ... See full document
22
Microneedle Mediated Vaccine Delivery: A Comprehensive Review
... the presence of antigen inside the particles. The rate at which DL-PLG biodegradation takes place is used for determination of the ratio of lactide to glycolide, and in case of co-injection of SEB toxoid microspheres ... See full document
33
Enhanced permeability of blood–brain barrier and targeting function of brain via borneol-modified chemically solid lipid nanoparticle
... The SLN and two kinds of BO-SLN injected via tail vein were evaluated using in vivo imaging systems. Further, 15 Kunming mice (20 ± 2 g) were divided into five groups randomly, and free Cy7 solution, Cy7-loaded SLN, and ... See full document
10
Ethosomes A Novel Approach For Transdermal Drug Delivery
... Transdermal drug delivery system was first introduced more than 20 years ...transdermal drug delivery system merged into larger ...Transdermal drug delivery system is a type of ... See full document
27
MR assessment of radiation induced blood brain barrier permeability changes in rat glioma model
... T1-weighted , gadolinium-enhanced spin-echo imaging with simultaneous measurement of arterial gadolinium is able to monitor reliabl y bloodbrain barrier permeability changes in the ti me[r] ... See full document
401
Current approaches to enhance CNS delivery of drugs across the brain barriers
... single-phase solution by titrating a milky emulsion with hexanol. A microemulsion is defined as a system of water, oil, and amphiphile, which is a single optically isotropic and thermodynamically stable liquid solution. ... See full document
5
A Review on Novel Techniques for Drug Delivery to the Brain
... Consequently, brain delivery of diverse drugs, including antifungals, chemotherapeutic compounds, anti-retrovirals, anti-epilepsy drugs and anti-ischemia drugs by liposomal formulations has been studied ... See full document
17
Neurological disorders and therapeutics targeted to surmount the blood–brain barrier
... the brain capillary endothelium and permeate into the ...the brain due to abundant availability of low-density lipoprotein receptor-related protein (LRP) while the antibodies inhibit T cell infiltration ... See full document
6
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