[PDF] Top 20 Las emociones en la filosofía de la ciencia
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A Quick Test of cognitive speed is sensitive in detecting early treatment response in Alzheimer's disease
... visit, treatment with rivastigmine, donepezil, or galantamine was ...because test changes are difficult to assess in patients with very poor test perfor- mance, because of low reliability ...of ... See full document
305
Assessing cognition and daily function in early dementia using the cognitive-functional composite: findings from the Catch-Cog study cohort
... ’ s disease (AD) is the leading cause of demen- tia worldwide and has been the target of clinical trials and intervention studies for many years ...mild cognitive impairment (MCI) [2]. Remark- ably, ... See full document
6
Can cognitive assessment really discriminate early stages of Alzheimer’s and behavioural variant frontotemporal dementia at initial clinical presentation?
... Alzheimer’s disease (AD) are two of the most com- mon dementia syndromes affecting people under the age of 65 ...and early differential diagnosis is crucial for disease management and ... See full document
17
APOE genotype and stress response - a mini review
... restore cognitive deficits in a mouse model of AD, though, since then, increasing evidence queries the effectiveness of bexarotene in preventing AD characteristic features [151, ...Alzheimer’s Disease As- ... See full document
6
For debate: substituting placebo controls in long-term Alzheimer's prevention trials
... the Alzheimer ’ s Association and the Alzheimer ’ s Drug Discovery Foundation, with participation from the US Food and Drug ...the Alzheimer ’ s Disease Cooperative Study ... See full document
58
The “rights” of precision drug development for Alzheimer’s disease
... Changes in the basic biology of AD—amyloid gener- ation, tau aggregation, inflammation, oxidation, mitochon- drial dysfunction, neurodegeneration, etc.—are linked to human cognition through neural circuits whose ... See full document
20
ALZHEIMER’S DISEASE: A REVIEW
... of Alzheimer disease in individuals with trisomy 21 has been related to a gene dosage effect with increased production of APP and subsequently ...to early-onset familial Alzheimer ... See full document
121
Disease-modifying drugs in Alzheimer's disease
... Pharmacologic treatment of AD involves acetylcholin- esterase inhibitors and memantine, which provide mainly symptomatic short-term benefits without counteracting the progression of the ...promising ... See full document
18
Eye movement analysis and cognitive processing: detecting indicators of conversion to Alzheimer’s disease
... processing speed and VSTM storage ...with disease duration, but not with cognitive measure, with the reverse being true for speed and the VSTM ...the early attentional deficits or the ... See full document
24
“Big Data” in neuroscience: open door to a more comprehensive and translational research
... ’ s Hospital (Boston, MA, USA) opened the second session, chaired by ...as Alzheimer ’ s disease (AD) and Parkinson ’ s Disease (PD) ...more sensitive to neurodegenerative ... See full document
30
Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels
... longitudinal cognitive data and genetic data were used to assess the association of the significant rQTL and G×G loci with rate of pro- gression or the rate of cognitive ...indicates cognitive ... See full document
121
The effects of repetitive transcranial magnetic stimulation in older adults with mild cognitive impairment: a protocol for a randomized, controlled three-arm trial
... AD: Alzheimer ’ s Disease; ADNI: Alzheimer ’ s Disease Neuroimaging Initiative; AE: Adverse Event; aMCI: Amnestic Mild Cognitive Impairment; ANCOVA: Analysis of ... See full document
18
18F-florbetaben Aβ imaging in mild cognitive impairment
... The Alzheimer ’ s Disease Neuroi- maging Initiative (ADNI) Grand Opportunities criterion for late MCI, which relies on a single test score of logical memory [47], also has value for increasing ... See full document
114
Distinguishing neurocognitive deficits in adult patients with NP-C from early onset Alzheimer’s dementia
... 16–19]. Early signs of cognitive impairment have been reported to comprise reduced executive function, processing speed, and verbal memory due to frontal-subcortical neural dysfunction [3, 17, ... See full document
5
A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer’s disease
... Participants were excluded from the study if they ex- hibited any significant neurologic disease other than AD. Additionally, subjects with a screening magnetic resonance imaging scan showing evidence of ... See full document
73
Independent effects of white matter hyperintensities on cognitive, neuropsychiatric, and functional decline: a longitudinal investigation using the National Alzheimer’s Coordinating Center Uniform Data Set
... The current study used FLAIR WMH to provide fur- ther insight into the complicated role of CSVD in early cognitive decline. Greater than 50% of dementia cases throughout the world are associated with CSVD ... See full document
10
Transcranial magnetic stimulation and transcranial direct current stimulation: treatments for cognitive and neuropsychiatric symptoms in the neurodegenerative dementias?
... the treatment response to tDCS treatment for depression, where long/long homozygotes displayed a larger improvement compared to short allele carriers, in a dose–response manner ...with ... See full document
337
Item distribution, internal consistency, and structural validity of the German version of the DEMQOL and DEMQOL–proxy
... Smith et al. observed the need to develop a conceptual framework that addressed the differences between the views expressed about HRQoL by people with dementia and their caregivers [14]. The results of the literature ... See full document
356
Perspectives on future Alzheimer therapies: amyloid-β protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer’s disease
... Likely owing to the challenges with active immunization described above, passive Aβ immunization programs are currently more numerous (Table 2). Eli Lilly and Com- pany has announced that a new phase 3 study in patients ... See full document
88
The need for harmonisation and innovation of neuropsychological assessment in neurodegenerative dementias in Europe: consensus document of the Joint Program for Neurodegenerative Diseases Working Group
... Aphasie Test; ACE-R: Addenbrooke ’ s Cognitive Examination; AD: Alzheimer ’ s disease; ADAS-CoG: Alzheimer ’ s Disease Assessment Scale-Cognition; ADL: Basic ... See full document
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