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Novel Putative Glycosylphosphatidylinositol-Anchored Micronemal Antigen of Plasmodium falciparum That Binds to Erythrocytes
... PF08_0008 encodes a 738-amino-acid protein (predicted molecular mass of ⬃ 83 kDa) (Fig. 1) with orthologues identi- fied only in other Plasmodium species, suggesting that it may perform a genus-specific function. ... See full document
6
PvGAMA reticulocyte binding activity: predicting conserved functional regions by natural selection analysis
... P. falciparum, given the avail- ability of robust in vitro culturing techniques for this parasite (currently unavailable for ...P. falciparum merozoite invasion of ...GPI-anchored micronemal ... See full document
5
Plasmodium reichenowi EBA 140 merozoite ligand binds to glycophorin D on chimpanzee red blood cells, shedding new light on origins of Plasmodium falciparum
... of erythrocytes with proteolytic enzymes may influence binding of antibodies or other ligands in two ways: they can either degrade the receptor, thwarting the binding, or trim off only the proteins that shield the ... See full document
6
Interaction between Endothelial Protein C Receptor and Intercellular Adhesion Molecule 1 to Mediate Binding of Plasmodium falciparum Infected Erythrocytes to Endothelial Cells
... uninfected erythrocytes) (32, 33) and EPCR-binding variants (5, 18), but the coreceptor-binding traits of EPCR binders remain ...1 binds ICAM-1 by using a Cos-7 protein expression system (20), but we ... See full document
6
Xanthine oxidase inhibits growth of Plasmodium falciparum in human erythrocytes in vitro
... of Plasmodium falciparum in human erythrocytes in ...O+ erythrocytes in medium supplemented, as required, with xanthine oxidase or ...P. falciparum, and that ... See full document
7
CEACAM6 acts as a receptor for adherent invasive E coli, supporting ileal mucosa colonization in Crohn disease
... carcinoembryonic antigen–related cell adhesion molecules 5 and 6 is upregulated in CD ileal ...onic antigen–related cell adhesion molecules (CEACAMs) ...reacting antigen [NCA]) in the ileal mucosa of ... See full document
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Acquisition of naturally occurring antibody responses to recombinant protein domains of Plasmodium falciparum erythrocyte membrane protein 1
... infected erythrocytes at between 1 and 5% parasitaemia were thawed through the sequential restoration of isoto- nicity ...infected erythrocytes were counted on an EPIC/XL flow cytometer ... See full document
6
Identification of ω-sites of Glycosylphosphatidylinositol Anchored Proteins
... The photo imaging can be used to observe the lateral mobility of GPI-Aps on the cell surface. It is considered that the GPI anchor provides a high lateral mobility for GPI- APs by preventing interactions between the ... See full document
6
Limited response of NK92 cells to Plasmodium falciparum infected erythrocytes
... To avoid missing the right time point of transcriptional changes induced by P. falciparum-iRBCs, we performed a time kinetics experiment investigating transcription in NK92 cells after 6, 12 and 24 hours of ... See full document
8
Downstream Effects of Haemoglobinase Inhibition in Plasmodium falciparum Infected Erythrocytes
... Our data suggest that the likely primary downstream effect of inhibition of hemoglobin degradation in erythrocytic Plasmodium falciparum is blockade of protein synthesis rather than prem[r] ... See full document
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PfEMP1 expression is reduced on the surface of knobless Plasmodium falciparum infected erythrocytes
... IFA examination of a Z-plane that encompasses only IE membrane better illustrates the punctate fluorescence signal distribution in both K + and K – clones (Fig. 5B). Time-lapse photography of a single IE over 6 minutes ... See full document
20
Recognition of Plasmodium falciparum mature gametocyte infected erythrocytes by antibodies of semi immune adults and malaria exposed children from Gabon
... Naturally acquired sexual-stage antibodies are pro- duced against gametocyte-infected erythrocyte surface antigens or gamete-specific antigens in the circulation and also against mosquito-stage parasites that act follow- ... See full document
6
Analysis of the stevor multigene family of Plasmodium falciparum
... Although the mechanistic details of var gene switching still remain to be elucidated, initial data have suggested that this mechanism is fundamentally different from that of VSG switching in African trypanosomes (section ... See full document
17
Targets of antibodies against Plasmodium falciparum–infected erythrocytes in malaria immunity
... as attractive vaccine candidates because of their importance as tar- gets of acquired immunity, their key role in disease pathogenesis, and their prominent exposure to the immune system. However, one major roadblock to ... See full document
125
A spiral scaffold underlies cytoadherent knobs in Plasmodium falciparum infected erythrocytes
... of Plasmodium falciparum malaria is caused by cytoadherence of infected erythrocytes, which promotes parasite survival by preventing clearance in the ...P. falciparum 3D7 ... See full document
14
Effect of nutrient deficiencies on in vitro Th1 and Th2 cytokine response of peripheral blood mononuclear cells to Plasmodium falciparum infection
... parasitized erythrocytes were used to induce cytokine response in PBMCs providing intimation that sterile immune protection focusing on whole parasite vaccines could be rewarding ... See full document
7
Antigen expression and host-parasite interactions of Plasmodium falciparum infections in Malawian paediatric patients
... severe falciparum malaria. A major polymorphic surface antigen implicated in cytoadhesion is the Plasmodium falciparum erythrocyte membrane protein 1 ...infected erythrocytes that are ... See full document
10
Characterization of two putative potassium channels in Plasmodium falciparum
... PfK, Plasmodium falciparum Potassium channel; PCR, polymerase chain reaction; GST, Glutathione S-transferase; PBS, Phosphate Buffered Saline; KAHRP, Knob-Associated Histidine Rich Protein; GRP(BiP), ... See full document
20
Genetic diversity of vaccine candidate antigens in Plasmodium falciparum isolates from the Amazon basin of Peru
... P. falciparum and Plasmodium ...of erythrocytes [22]. As with the other P. falciparum vaccine candidate sequences, Pfama-1 is highly polymorphic [23-25] with most of polymorphisms occurring in ... See full document
16
The Plasmodial Surface Anion Channel Is Functionally Conserved in Divergent Malaria Parasites
... key RBCs before and after in vitro infection with P. knowlesi, a parasite species chosen in part for its phylogenetic distance from P. falciparum. Our osmotic lysis and radioisotope uptake studies revealed ... See full document
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