[PDF] Top 20 Metodología de la Enseñanza del Fútbol
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Targeting multidrug resistance in cancer by natural chemosensitizers
... of cancer is not limited to developing countries but also to already developed ones and the burden of cancer affects ...diagnosed cancer cases with 8.2 mil- lion deaths due to cancer were ... See full document
5
miR-145 sensitizes breast cancer to doxorubicin by targeting multidrug resistance-associated protein-1
... Recent studies have shown that miRNAs may play an important role in MRP1-mediated drug-resistance [18, 19]. miR-1291 has been demonstrated to affect drug disposition and increase chemosensitivity by ... See full document
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<p>miR-625 reverses multidrug resistance in gastric cancer cells by directly targeting ALDH1A1</p>
... gastric cancer is the fi fth most common malignancies and the second leading cause of cancer-related death in the ...as multidrug resistance (MDR), which becomes a huge obstacle for effective ... See full document
29
The role of photodynamic therapy on multidrug resistant breast cancer
... breast cancer, a subpopulation of cells that displayed stem cell properties was identi- fied and characterized by cell surface markers CD44 expression and are thus called “breast cancer stem cells” (BCSCs) ... See full document
5
Function and membrane targeting of the multidrug resistance associated protein 2
... Analysis of expression of cMOAT MRP2, MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene MRPl, in human cancer cell lines.. Expression of human MRP6, a [r] ... See full document
5
Autophagy and multidrug resistance in cancer
... chemoresistant cancer cell line SGC7901/VCR develops upon exposure to vincristine and exhibits increased autophagy, which is regulated by Atg12 and high-mobility group box 2 ...NAs) targeting Atg12 and ... See full document
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Stimuli-Responsive Nanomedicines for Overcoming Cancer Multidrug Resistance
... Some anticancer drugs are more efficient when engulfed into the nucleus by targeting DNA [121, 122]. Therefore, nanoparticles with the ability to deliver chemotherapeutics into the nucleus and promote drug ... See full document
10
Folate-mediated mitochondrial targeting with doxorubicin- polyrotaxane nanoparticles overcomes multidrug resistance
... this resistance due to specific molecular features, including a size of approximately 101 nm, a zeta potential of ...overcoming multidrug-resistant ... See full document
72
Reversing multidrug resistance in breast cancer cells by silencing <em>ABC</em> transporter genes with nanoparticle-facilitated delivery of target siRNAs
... siRNA targeting either ABCG2 or ABCB1 transporter with carbonate apatite nanoparticles demonstrated a modest 15% to 30% enhancement in c hemosensitivity in MCF-7 cells (Tables ...simultaneously targeting ... See full document
7
Natural Products Modulate the Multifactorial Multidrug Resistance of Cancer
... Classical multidrug resistance exerts increased drug efflux and lowers intracellular drug ...pathic natural products, such as microtubule-stabilizing taxanes (paclitaxel and docetaxel), vinca ... See full document
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Trametinib modulates cancer multidrug resistance by targeting ABCB1 transporter
... colon cancer cells [36], and have synergistic effects with metformin on cell viability and tumor growth in NRAS mutant cancer ...pancreas cancer, the addition of trametinib to gemcitabine did not ... See full document
73
ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal
... these resistance mechanisms [1]. The resistance mechanism is called typi- cal MDR or classical MDR when overexpression of the membrane efflux pumps is involved in ...anti- cancer drugs) out of cells ... See full document
6
Multidrug resistance in breast and bladder cancer cell lines
... there was no increased expression o f Pgp or its cognate mRNA in these cell lines, which include the small cell lung cancer cell line HL69AR. Although exhibiting MDR, net drug accumulation and efflux appeared ... See full document
20
<p>Research Progress Evaluating the Function and Mechanism of Anti-Tumor Peptides</p>
... (C) Positional scanning combinatorial synthesis of pep- tides (PS-SPCLs) has become a useful tool in recent years for cancer drug research, vaccine development, and protease research. In this research, many subset ... See full document
7
Expression of LRP and MDR1 in locally advanced breast cancer predicts axillary node invasion at the time of rescue mastectomy after induction chemotherapy
... breast cancer, where chemotherapy is the mainstay of treatment, a possible implication of the MDR1 gene in resistance and outcome has been found, directly or indirectly, in most studies since the initial ... See full document
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Key words
... The process of invasion is accompanied by alterations in the expression of cytokeratins and proteins levels of MUC1 (Mucins1) family, point- ing to the destabilization of cytoskeleton and the process can be monitored ... See full document
6
Long term exposure to irinotecan reduces cell migration in glioma cells
... In this study, we set out to determine the cellular effects of long-term exposure to topoisomerase inhibitors in a glioma cell line (C6), focusing on acquired cross-resistance and invasion. The C6 glioma cell line ... See full document
21
Pattern of ABCC Transporter Gene Expression in Pediatric Patients with Relapsed Acute Lymphoblastic Leukemia
... For each participant a questionnaire about their clinical, pathological, and demographic characteristics was completed by a physician. These characteristics included age at the time of diagnosis, sex, ... See full document
17
Cancer Stem Cells in the Personalized Therapy of Colorectal Cancer
... induce resistance to chemotherapeutics used in CRC, as seen in experiments using 5-Fluorouracil (5-FU), the treatment of choice for this cancer ...of cancer stem cells in novel treatment approaches ... See full document
8
Multidrug Intrinsic Resistance Factors in Staphylococcus aureus Identified by Profiling Fitness within High Diversity Transposon Libraries
... impacting resistance to multiple antibiotics could inform the design of new compounds and lead to more-effective antimicrobial ...in resistance to individual antibiotics, including graRS and vraFG ... See full document
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