[PDF] Top 20 Motives inhibitors of the use of Moodle in higher education teachers
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Inhibition of SIRT1 combined with gemcitabine therapy for pancreatic carcinoma
... of gemcitabine and sirtinol was measured with a xenogeneic nude mouse model with human BxPC-3 pancreatic cancer ...the pancreatic cancer cells were subcutaneously injected in the flank of BALB/c-nu ... See full document
6
High-intensity focused ultrasound therapy in combination with gemcitabine for unresectable pancreatic carcinoma
... with pancreatic cancer, which could not be surgically resected at the Second Artillery General Hospital from March 2008 to January ...of pancreatic head carcinomas, and 23 cases of carcino- mas of ... See full document
6
The anti-fibrotic effect of GV1001 combined with gemcitabine on treatment of pancreatic ductal adenocarcinoma
... of gemcitabine in mouse pancreatic model was improved by co-administration of a drug that depletes tumor-associated stromal tissue by inhibition of the Hedgehog cellular signaling pathway ...with ... See full document
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A Phase II Study of Capecitabine Combined with Gemcitabine in Patients with Advanced Gallbladder Carcinoma
... and gemcitabine are used in the treatment of a variety of solid tumors including pancreatic and biliary tract ...and gemcitabine to treat patients with unresectable or metastatic gallbladder ... See full document
10
Molecular landscape of pancreatic cancer: implications for current clinical trials
... new pancreatic cancer protocols registered during the past three years identified 314 protocols (search criteria: trials registered in database during the period 03/01/2011 to 03/01/2014; pancreatic cancer; ... See full document
144
Dual targeting of HER1/EGFR and HER2 with cetuximab and trastuzumab in patients with metastatic pancreatic cancer after gemcitabine failure: results of the “THERAPY”phase 1-2 trial
... with pancreatic cancer, was associated with increased toxicity ...with pancreatic cancer and treated with combined erlotinib and gemcitabine were classified in two groups (high and low ... See full document
293
SIRT1 overexpression is an independent prognosticator for patients with esophageal squamous cell carcinoma
... Despite advance in perioperative management and surgi- cal techniques, the prognosis of patients with ESCC re- mains poor [1, 2]. Even after radical surgery, patients still develop recurrences and metastases. Over the ... See full document
5
Vandetanib plus gemcitabine versus placebo plus gemcitabine in locally advanced or metastatic pancreatic carcinoma (ViP): a prospective, randomised, double blind, multicentre phase 2 trial
... with pancreatic cancer treated with chemoradiation plus sorafenib ...with gemcitabine who developed a rash had a doubling of survival compared with those not developing a rash on vandetanib and those ... See full document
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Effectiveness of capecitabine with or without docetaxel therapy for the treatment of patients with advanced urothelial carcinoma: a single-institution experience
... docetaxel combined with oxaliplatin [27], gemcitabine [28, 29] or ifosfamide and cisplatin regimen [30] were mostly tolerable and moderately active (RR 27–47%) for advanced UC after failure of ... See full document
13
Beclin1 inhibition promotes autophagy and decreases gemcitabine–induced apoptosis in Miapaca2 pancreatic cancer cells
... Miapaca2 cells were transfected with corresponding plasmids in 24-well plates and incubated for 24 h. Then cells were exposed to adequate density of Gemcitabine (3 μg/ml). After 24 h of treatment, cells were ... See full document
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Gemcitabine reduces MDSCs, tregs and TGFβ 1 while restoring the teff/treg ratio in patients with pancreatic cancer
... in pancreatic cancer have thus far been absent [10, ...state combined with the dense profile of pancreatic lesions likely need to be combated to achieve an adequate anti-tumor immune ...as ... See full document
5
Angiogenesis in pancreatic ductal adenocarcinoma: A controversial issue
... with gemcitabine together with this drug or gemcitabine alone, show a significantly increased response and mOS ...of gemcitabine, in KPC mice model ...angiogenesis inhibition. Moreover, ... See full document
503
Astragaloside IV represses high glucose-induced mesangial cells activation by enhancing autophagy via SIRT1 deacetylation of NF-κB P65 subunit
... the inhibition of NF- κ B signaling by enhancing SIRT1 ...the SIRT1 activator or ...an SIRT1 activator to inhibit the acetylation of NF- κ B p65 subunit and enhances autophagy in ... See full document
16
SIRT1 inhibits adipogenesis and promotes myogenic differentiation in C3H10T1/2 pluripotent cells by regulating Wnt signaling
... of SIRT1. To explore the function of SIRT1 in C3H10T1/2 committed to the adipocyte lineage, SIRT1 activator (resveratrol)/inhibitor (nicotinamide) was added to C3H10T1/2 cells with 5-AZA during com- ... See full document
13
Opportunities and Resistance to Signal-targeted Therapies in Pancreatic Cancer: What Can We Learn from Proteomic Studies?
... targeted therapy was approved there in ...with Gemcitabine individually provides no significantly different objective response (measurable response) as compared to placebo plus Gemcitabine [16 , ... See full document
23
Novel Hyaluronic Acid Conjugates for Dual Nuclear Imaging and Therapy in CD44-Expressing Tumors in Mice In Vivo
... of Gemcitabine (Gem) have been hindered by its short biological half-life, high dose and development of drug ...cancer therapy, in vitro tracking or single photon emission computed tomography/computed ... See full document
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Extended pancreatectomy in pancreatic ductal adenocarcinoma: definition and consensus of the International Study Group for Pancreatic Surgery (ISGPS)
... At present, no randomized trials are available comparing standard pancreatectomy to extended pancreatectomy. Moreover it is unlikely that such a trial will ever be undertaken, because this might mean comparing complete ... See full document
104
The combination therapy of high intensity focused ultrasound with radiotherapy in locally advanced pancreatic carcinoma
... the therapy, and written informed consents were ...through pancreatic biopsies and computed tomography (CT) images or magnetic reson- ance imaging (MRI), and no tumor metastasis was found; (2) a single ... See full document
5
Plasma pharmacokinetics after combined therapy of gemcitabine and oral S-1 for unresectable pancreatic cancer
... Our results demonstrated that pre-administration of S-1 did not increase Cmax, AUCinf or T1/2 of plasma GEM (Table 1, Figure 2). Nakamura et al . performed a PK study of GEM with S-1; S-1 was given orally at a dose of 30 ... See full document
7
Interaction of standardized mistletoe (Viscum album) extracts with chemotherapeutic drugs regarding cytostatic and cytotoxic effects in vitro
... crease therapy-related adverse drug reactions, to in- crease response rates and to improve disease symptom control, quality of life and overall survival ... See full document
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