[PDF] Top 20 La percepción del funcionamiento familiar en niños de la tercera infancia
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Identification of plasma microRNA profiles for primary resistance to EGFR-TKIs in advanced non-small cell lung cancer (NSCLC) patients with EGFR activating mutation
... Total RNA was isolated using mirVana miRNA isolation kit (Ambion). For miRNA cDNA synthesis, RNA was re- verse transcribed using a miRNA reverse transcription kit (Applied Biosystems) in combination with the stem-loop ... See full document
42
Intrinsic resistance to EGFR tyrosine kinase inhibitors in advanced non-small-cell lung cancer with activating EGFR mutations
... Several EGFR TKIs have been explored and evaluated as potent agents for the treatment of NSCLC with activating EGFR mutations in large randomized Phase III clinical trials (Table ...of ... See full document
12
Mutational profiling of non-small-cell lung cancer patients resistant to first-generation EGFR tyrosine kinase inhibitors using next generation sequencing
... with advanced non-small-cell lung cancer (NSCLC) harboring sensitive epithelial growth factor receptor (EGFR) mutations invariably develop acquired ... See full document
13
Identification of genetic alterations associated with primary resistance to EGFR-TKIs in advanced non-small-cell lung cancer patients with EGFR sensitive mutations
... of EGFR-TKIs, were not be tested in this ...of primary diagnosis, and the second biopsies were not performed before EGFR-TKIs therapy, so the genetic status may have changed with the ... See full document
8
BIM deletion polymorphisms in Hispanic patients with non-small cell lung cancer carriers of EGFR mutations
... Lung cancer is the leading cause of cancer related death in the developed countries and in Latin America, and non–small-cell lung cancer (NSCLC) accounts for ... See full document
30
Association of integrin beta1 and c-MET in mediating EGFR TKI gefitinib resistance in non-small cell lung cancer
... some patients are initially sensitive to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs), resistance invariably ...induce EGFR TKIs resistance in ... See full document
34
Circulating cell-free DNA as a prognostic and predictive biomarker in non-small cell lung cancer
... of patients was used in other selected study ...of patients included in this study was 2518, ranging from 22 [21, 37] to 446 [29] cases per ...in NSCLC [9, 19-22, ...for NSCLC [20, 23, 25, ... See full document
71
Impact of epidermal growth factor receptor (EGFR) activating mutations and their targeted treatment in the prognosis of stage IV non small cell lung cancer (NSCLC) patients harboring liver metastasis
... on patients’ epidemiology We divided our population in two groups, whether liver involvement was present or ...of patients were compared in order to detect potentially different clinical characteristics ... See full document
24
Prolonged survival of patients with EGFR mutated non small cell lung cancer with solitary brain metastases treated with surgical resection of brain and lung lesions followed by EGFR TKIs
... from NSCLC patients who harbored EGFR mutations and who pre- sented solitary BM at diagnosis in our institute between January 2012 and December ...72 NSCLC patients with solitary BM ... See full document
14
Real-world practice patterns for patients with advanced non-small cell lung cancer: multicenter retrospective cohort study in Japan
... 2013. Patients 18 years and older who initiated first-line sys- temic therapy for newly diagnosed stage IIIB or IV NSCLC during this ...Eligible patients were identified by retrospective chart review ... See full document
6
EGFR plasma mutation in prediction models for resistance with EGFR TKI and survival of non-small cell lung cancer
... IV NSCLC patients (including 33 newly diagnosed cases) with either E19del or L858R mutation who were treated with Erlotinib or Gefitinib were selected for this study from January 2016 to July 2018 at ... See full document
19
Quantum dots immunofluorescence histochemical detection of <em>EGFR</em> gene mutations in the non-small cell lung cancers using mutation-specific antibodies
... Resected tumor specimens were stained simultaneously using these three antibodies according to the manufacturer’s instructions. Antigen retrieval was the same as for the QDs- IHC method. Intrinsic peroxidase activity was ... See full document
7
Molecular insights: Suppression of EGFR and AKT activation by a small molecule in non-small cell lung cancer
... governing cell growth, proliferation, and survival. Overexpression of EGFR is seen in many solid tumors, including NSCLC ...Although EGFR is identified as an important antitumor target, ... See full document
5
Combination of EGFR-TKIs with chemotherapy versus chemotherapy or EGFR-TKIs alone in advanced NSCLC patients with EGFR mutation
... involved patients who had a history of cardiac diseases and who underwent, physical examination, hematology, postoperative computed tomogra- phy (CT) of the chest, biochemistry, a chest radiograph, upper abdomen, ... See full document
80
Comparison of next generation sequencing, SNaPshot assay and real-time polymerase chain reaction for lung adenocarcinoma EGFR mutation assessment
... for lung [29, 30], head and neck [31] and colorectal adenocarcinomas ...germline mutation and occurrence frequency is comparable for cancer and healthy subjects ...between lung adenocarcinoma ... See full document
6
<p>Dual Targeting of the Epidermal Growth Factor Receptor Using Combination of Nimotuzumab and Erlotinib in Advanced Non-Small-Cell Lung Cancer with Leptomeningeal Metastases: A Report of Three Cases</p>
... with EGFR-mutated NSCLC with brain metastases were treated with EGFR-TKI combined with bevacizumab while the other cases used EGFR-TKI ...in non-squamous ...the patients, we did ... See full document
7
Non-small cell to small cell lung cancer on PD-1 inhibitors: two cases on potential histologic transformation
... Subsequently, new nodules appeared in the left lung on follow-up CT scan in May 2014. These were FDG avid on PET scan, with a pleural-based 1.5 × 1.1 cm mass (SUV 4.9) in left upper lobe, 2.3 × 2.4 cm mass (SUV ... See full document
11
The effectiveness of EGFR-TKIs against brain metastases in EGFR mutation-positive non-small-cell lung cancer
... involving EGFR-TKI and accounts of its use in intracranial lesions are available only in a few case reports or some small studies with limited number of ...of EGFR-TKI in this setting still remains ... See full document
9
Overcoming erlotinib resistance in EGFR mutation-positive lung adenocarcinomas through repression of phosphoglycerate dehydrogenase
... metabolic profiles of 16HBE, PC9 and PC9ER4 cells by measuring their oxygen consumption rate (OCR), an indicator of mitochondrial respiration activity, and extracellular acidification rate (ECAR), an indicator of ... See full document
186
Genomic profiling toward precision medicine in non-small cell lung cancer: getting beyond EGFR
... [33%], EGFR [14%], BRAF [10%], MET [7%], and RIT1 [2%]) and tumor suppressors (TP53 [46%], STK11 [17%], KEAP1 [17%], NF1 [11%], RB1 [4%], and CDKN2A ...(63%); cell-cycle regulation dysfunction (64%); ... See full document
8
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