[PDF] Top 20 Perfil molecular en pacientes con cáncer de mama del Hospital III EsSalud José Cayetano Heredia Piura 2015-2017
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Baicalein suppresses metastasis of breast cancer cells by inhibiting EMT via downregulation of SATB1 and Wnt/β-catenin pathway
... of baicalein on the expression of target proteins in vivo were analyzed by ...with SATB1 (1:100), Wnt1 (1:50), β -catenin (1:50), E-cadherin (1:100), vimentin (1:100), and SNAIL (1:80) primary ... See full document
17
MicroRNA-338-3p suppresses ovarian cancer cells growth and metastasis: implication of Wnt/catenin beta and MEK/ERK signaling pathways
... regulated cancer related growth, metabolism, gen- omic stability, apoptosis, epithelial to mesenchymal transition (EMT), tumor cell microenvironment and angiogenesis have been well demonstrated [35, ...in ... See full document
5
<p>Downregulation of MMSET impairs breast cancer proliferation and metastasis through inhibiting Wnt/β-catenin signaling</p>
... of Wnt/ β -catenin signaling ...in breast cancer cells (Figure ...of Wnt/ β -catenin pathway, were also significantly decreased by knockdown of MMSET in ... See full document
6
Long noncoding RNA H19 mediated the chemosensitivity of breast cancer cells via Wnt pathway and EMT process
... development. EMT is essential for developmental processes and has also been shown to occur in wound healing, in organ fibrosis, and in the initiation of metastasis in cancer ...progression. ... See full document
14
Original Article Baicalein inhibits the invasion, migration and epithelial-mesenchymal transition of BGC-823 cells through NF-κB/Snail signaling pathway
... [1-3]. EMT, which is characterized by the decreased expres- sion of epithelial markers including keratins, E-cadherin and claudin, and increased expres- sion of mesenchymal markers such as N-cad- herin and ... See full document
106
Overexpression of Klotho suppresses liver cancer progression and induces cell apoptosis by negatively regulating wnt/β catenin signaling pathway
... and cancer progression has been studied [10–12]; however, the role and mechanism in a variety of cancers remain ...ovarian cancer patients, which demonstrated that high expression of secreted Klotho was ... See full document
8
Wnt/β-catenin signalling in ovarian cancer: Insights into its hyperactivation and function in tumorigenesis
... ovarian cancer (EOC) is the deadliest female malignancy. The Wnt/ β -catenin pathway plays critical roles in regulating embryonic development and physiological ...This pathway is ... See full document
97
FH535 increases the radiosensitivity and reverses epithelial to mesenchymal transition of radioresistant esophageal cancer cell line KYSE 150R
... two cells groups (KYSE-150 and KYSE-150R) in the exponential growth phase using the cell lysis buffer, which containing 20 mM Tris (pH ...USA), Beta-Catenin Phospho (pS33/S37) (1:1,000) (9561 s, Cell ... See full document
11
Circular RNAs: Regulators of Cancer-Related Signaling Pathways and Potential Diagnostic Biomarkers for Human Cancers
... as functioning as miRNA sponges by sequestering miRNA thereby affecting the stability of target mRNAs and dynamically regulating mRNA translation (Figure 1) [24-26]. Recently, Memczak et al. detected 1950, 1903, and 724 ... See full document
12
Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2
... promote EMT in breast cancer cells [20], and IL-8 was one of the key molecules which affected leptin-mediated ...leptin-induced EMT of breast cancer cells, gene ... See full document
19
Original Article FH535 suppresses the growth of osteosarcoma in vitro and vivo via downregulation Wnt/β-catenin signaling pathway
... Tumor metastasis is a complex multi-step pro- cess and a critical event in tumor cell invasion is the degradation of the extracellular matrix (ECM) and basement membrane that act as a barrier to the spread of ... See full document
166
Original Article miR-15b facilitates the progression of colorectal cancer via targeting β-catenin and Axin2
... of Wnt sig- naling pathway: on one hand, Axin2 participat- ed to form the “destruction complex” promot- ing β-catenin degradation and therefore im- peded the Wnt signal transduction; on the ... See full document
271
Loss of β-catenin in adrenocortical cancer cells causes growth inhibition and reversal of epithelial-to-mesenchymal transition
... of EMT plays a pivotal role for the progress of embryonic development and later for wound healing, the abnormal activation of EMT programs can lead to tissue fibrosis and organ failure and, cancer ... See full document
48
Wnt-beta-catenin pathway signals metastasis-associated tumor cell phenotypes in triple negative breast cancers
... active beta-catenin moves to the nucleus where it interacts with members of the TCF and LEF family of transcription factors to induce transcription of beta-catenin’s downstream target genes including ... See full document
22
TET1-mediated DNA hydroxymethylation activates inhibitors of the Wnt/β-catenin signaling pathway to suppress EMT in pancreatic tumor cells
... TET1 suppresses pancreatic tumor metastasis in vivo To simulate pancreatic tumor metastasis, we established an orthotopic pancreatic metastatic model in nude ...weeks, metastasis was ... See full document
305
Lgr5 in cancer biology: functional identification of Lgr5 in cancer progression and potential opportunities for novel therapy
... dendritic cells, and adaptive immune T cells ...stem cells under steady-state conditions ...stem cells in the intes- tine, whilst depletion of Tregs would cause a dramatic reduction in the ... See full document
40
Downregulation of human Wnt3 in gastric cancer suppresses cell proliferation and induces apoptosis
... Total RNA was extracted from cells after transfection using an RNAsimple Total RNA kit (Tiangen, Beijing, People’s Republic of China) according to the manufacturer’s instruc- tions. The RNA was quantified using a ... See full document
17
<p>KLHL22 Regulates the EMT and Proliferation in Colorectal Cancer Cells in Part via the Wnt/β-Catenin Signaling Pathway</p>
... trigger cancer cell metastasis and invasion by causing cells to lose their epithelial character- istics and adhesive contacts with their neighboring ...an EMT event are decreasing expression ... See full document
21
CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathway
... many cancer types. In addition, downregulation of VDAC1 expression inhibits tumor development ...the metastasis of breast cancer [15, 20, ...colorectal cancer (CRC) remain to be ... See full document
33
Autophagy suppresses proliferation of HepG2 cells via inhibiting glypican-3/wnt/β-catenin signaling
... Cells in six-well plates were washed twice with ice-cold PBS, and total RNA was extracted using Trizol reagent according to the manufacturer’s instructions. The purity and concentra- tion of RNA were measured ... See full document
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