[PDF] Top 20 Um relato da transformação da prática pedagógica em creche através da metodologia de trabalho de projeto
Has 10000 "Um relato da transformação da prática pedagógica em creche através da metodologia de trabalho de projeto" found on our website. Below are the top 20 most common "Um relato da transformação da prática pedagógica em creche através da metodologia de trabalho de projeto".
The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G<sub>2</sub>/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells
... the cells were treated with fresh medium alone, control vehicle alone ...µ M) for 24 hours at 37 ° ...MDA-MB-231 cells were treated with 1.0 µ M ALS for 4, 8, 12, 24, 48, and 72 ...ALS-induced ... See full document
5
Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway
... therapeutics. Alisertib (ALS, MLN8237) is a selective Aurora kinase A inhibitor that displays anticancer effects on several types of ...the cell growth, apoptosis, ... See full document
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<p>Inhibition of Aurora Kinase A by Alisertib Reduces Cell Proliferation and Induces Apoptosis and Autophagy in HuH-6 Human Hepatoblastoma Cells</p>
... p38 MAPK signaling plays an essential role in the occurrence and development of tumors associated with cell growth and programmed cell ...Additionally, p38 MAPK ... See full document
7
Plumbagin induces G<span style="font-size: 8.3333330154419px">2</span>/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells
... against human cell division cycle protein 2 homolog (Cdc2), cyclin B1, p53, p21/Waf1, p27 Kip1, Bcl-2-like protein 4/Bcl-2- associated X protein (Bax), Bcl-2, ... See full document
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Danusertib, a potent pan-Aurora kinase and ABL kinase inhibitor, induces cell cycle arrest and programmed cell death and inhibits epithelial to mesenchymal transition involving the PI3K/Akt/mTOR-mediated signaling pathway in human gastric cancer AGS and NCI-N78 cells
... cellular autophagy level and the mechanisms of danusertib-induced autophagy in AGS and NCI-N78 cells using a Cyto-ID autophagy detection ...NCI-N78 cells were seeded into an 8-well ... See full document
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<div>Alisertib, an Aurora kinase A inhibitor, induces apoptosis and autophagy but inhibits epithelial to mesenchymal transition in human epithelial ovarian cancer cells</div>
... Ovarian cancer is a leading killer of women, and no cure for advanced ovarian cancer is ...available. Alisertib (ALS), a selective Aurora kinase A (AURKA) inhibitor, has shown ... See full document
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Alisertib induces cell cycle arrest and autophagy and suppresses epithelial-to-mesenchymal transition involving PI3K/Akt/mTOR and sirtuin 1-mediated signaling pathways in human pancreatic cancer cells
... against human cyclin-dependent kinase (CDK) 1/CDC2, CDK2, cyclin B1, cyclin D1, p21 Waf1/ Cip1, p27 Kip1, p53, Sirt1, p38 MAPK, phosphorylated (p-) p38 MAPK at Thr180/Tyr182, ... See full document
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Inhibition of mitotic Aurora kinase A by alisertib induces apoptosis and autophagy of human gastric cancer AGS and NCI-N78 cells
... against human p21 Waf1/Cip1, p27 Kip1, p53, cyclin B1, cyclin-dependent kinase 1(CDK1/cell division cycle protein 2 homologue [CDC2]/CDKN1), the p53 upregu- lated modulator of ... See full document
5
ZSTK474, a specific class I phosphatidylinositol 3-kinase inhibitor, induces G1 arrest and autophagy in human breast cancer MCF-7 cells
... (PI3K) inhibitor ZSTK474 were investigated on human breast cancer cell ...induced cell cycle arrest at G1 phase, but no obvious apoptosis ...G1 arrest ... See full document
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Role of dual PI3/Akt and mTOR inhibition in Waldenstrom’s Macroglobulinemia
... lymphoplasmacytic cells in the bone marrow and IgM secretion in the peripheral ...WM cells present with a constitutive activation of the PI3K/ Akt pathway, sustained by decreased expression of PTEN ... See full document
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Marketed drugs used for the management of hypercholesterolemia as anticancer armament
... and 2 mL of serum obtained after sample centrifugation for 15 min at 3,000 rpm was transferred into cryovials (Greiner Bio-One GmbH 5 mL U-Bottom cryovials CE-IVD; Bioline Scientific, Athens, Greece) and stored at ... See full document
9
Original Article Salidroside induces apoptosis via ERK1/2 in human leukemia K562 cells
... induce cell cycle arrest in K562 cells in a dose-dependent ...A549 cells by G1-phase arrest markedly, but inhibitory action of higher concentration sali- droside (4 μg/ml) on two ... See full document
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Original Article Ponicidin induces apoptosis of human cervical cancer HeLa cell line through the PI3K/Akt and MAPK signaling pathways
... that MAPK signal- ing pathway played a crucial role in cell prolif- eration, autophagy and ...and p38 MAPK, but no obvious effects were found on total ERK1/2, JNK1/2 and ... See full document
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The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferation
... the cell death observed in Figure 3D. In A549 cells, cleavage of PARP-1 was very slightly induced 24 hr after TC-A2317 treatment, but reduced at later stages of TC-A2317 treatment ...A549 cells had ... See full document
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Isoliquiritigenin induces apoptosis and autophagy and inhibits endometrial cancer growth in mice
... Endometrial cancer is the most common cancer in women, typically with onset after ...on human endometrial cancer both in vitro and in ...telomerase-immortalized human endometrial ... See full document
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Original Article Apelin induces the proliferation, migration and expression of cytoskeleton and tight junction proteins in human RPE cells via PI-3K/Akt and MAPK/Erk signaling pathways
... in human RPE cells via PI-3K/Akt and MAPK/Erk signaling ...in human RPE cells using MTS and transwell chamber ...PI-3K/ Akt and MAPK/Erk ... See full document
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Combating head and neck cancer metastases by targeting Src using multifunctional nanoparticle-based saracatinib
... Six-week-old NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice were purchased from the Jackson Laboratory (Bar Harbor, ME, USA), and all animal experiments were ap- proved by the Institutional Animal Care and Use Com- mittee ... See full document
5
Silencing of CXCR4 sensitizes triple-negative breast cancer cells to cisplatin
... stem cells, endothelial and epithelial cells, and cancer cells ...in cell proliferation, migration, and metastasis of solid tumors in a variety of cancers, such as gastric ... See full document
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<p>The natural flavonoid glycoside vitexin displays preclinical antitumor activity by suppressing NF-κB signaling in nasopharyngeal carcinoma</p>
... NPC cells, attenuated NPC stem cell tumorigenicity, suppressed tumor growth and enhanced the sensitivity of NPC cells to cisplatin treatment by dysregulating JAK/STAT signaling pathway, which ... See full document
5
Original Article Lycorine induces apoptosis in human pancreatic cancer cell line PANC-1 via ROS-mediated inactivation of the PI3K/Akt/mTOR signaling pathway
... Pancreatic cancer is a common cancer of the digestive system and is a leading cause of mor- bidity and mortality ...pancreatic cancer cell line PANC-1. Apoptosis is a programmed ... See full document
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