[PDF] Top 20 Relatório de estágio realizado na empresa Ribermold
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Silica nanoparticle-induced oxidative stress and mitochondrial damage is followed by activation of intrinsic apoptosis pathway in glioblastoma cells
... predominantly induced apoptotic death in LN229 ...of oxidative stress induced by enhanced reactive oxygen-species ...was followed by deregulated expression of genes encoding the ... See full document
9
In vitro cytotoxicity and induction of apoptosis by silica nanoparticles in human HepG2 hepatoma cells
... that silica nanoparticles in the 7–50 nm size range exhibited obvious proliferative inhi- bition in human hepatoma HepG2 cells in a size-, time-, and dose-dependent manner, whereas they appeared to be less ... See full document
16
Arsenic trioxide induces oxidative stress, DNA damage, and mitochondrial pathway of apoptosis in human leukemia (HL-60) cells
... 3 activation and DNA fragmentation ...causes apoptosis in melanoma cells (HT-144) by caspase-3 activation and DNA damage ...duces intrinsic pathway of apoptosis in ... See full document
19
<p>Silver Nanoparticle-Induced Apoptosis in ARPE-19 Cells Is Inhibited by <em>Toxoplasma gondii</em> Pre-Infection Through Suppression of NOX4-Dependent ROS Generation</p>
... the cells with phosphate-buffered saline (PBS), proteins were extracted using the PRO-PREP Protein Extraction Solution (iNtRON Biotechnology, Seoul, Korea) and incubated with complete protease inhibitor cocktail ... See full document
13
Coenzyme Q10 partially restores pathological alterations in a macrophage model of Gaucher disease
... highest prevalence, is caused by mutations in the GBA1 gene that results in defective and insufficient activity of the enzyme β-glucocerebrosidase (GCase). Decreased catalytic activity and/or instability of GCase leads ... See full document
51
Silica nanoparticles induce liver fibrosis via TGF-β<sub>1</sub>/Smad3 pathway in ICR mice
... mechanisms induced by intravenous injection of SiO 2 NPs in ...fibroblast cells, and induced oxidative damage and apoptosis, thus activating the TGF- β 1 /Smad3 signaling ... See full document
16
Manumycin induces apoptosis in prostate cancer cells
... caspase-3 activation induced by manumycin. cells were treated with dimethyl sulfoxide (DMsO; control) or 32 µM manumycin in the presence or absence of 50 µM caspase-9 ...The cells were lysed ... See full document
8
ZnO nanoparticle induced oxidative stress triggers apoptosis by activating JNK signaling pathway in cultured primary astrocytes
... The intracellular levels of ROS were determined by meas- uring the oxidative conversion of DCFH-DA to fluores- cent compound dichlorofluorescin (DCFH) [40]. Briefly, astrocytes were placed in 24-well for 12 h, ... See full document
5
ZNF32 protects against oxidative stress-induced apoptosis by modulating C1QBP transcription
... serious oxidative stress on cells, cause damage to cellular components such as DNA, proteins, and lipids, and ultimately induce cell ...cancer cells compared with normal cells, ... See full document
24
Breast cancer: Small molecules targeting apoptosis, a prospective approach to safe scientific success
... through activation of the death-receptor complex and caspase 8 [13] The other molecule, GDC-0152 has the best profile of these compounds; it binds to the XIAP BIR3 domain, the BIR domain of ML-IAP, and the BIR3 ... See full document
130
Emodin induces apoptosis of human cervical cancer hela cells via intrinsic mitochondrial and extrinsic death receptor pathway
... cancer cells and often bring severe adverse effect, including bone marrow suppression, nerve injury, gastrointestinal adverse reactions, renal impairment and second cancer occurrence ... See full document
11
Original Article Lovastatin induces apoptosis of HepG-2 cells by activating ROS-dependent mitochondrial and ER stress pathways
... tumor cells are among the main reasons lead- ing to the bad ...lovastatin induced HCC cell apoptosis by activating mitochondrial apo- ptotic signals ...HCC cells are still absent, and ... See full document
69
PROTECTIVE EFFECT OF AUTRANELLA CONGOLENSIS AND SAPIUM ELLIPTICUM STEM BARK EXTRACTS AGAINST HEPATOTOXICITY INDUCED BY THIOACETAMIDE
... An excess of free radicals contribute to the failure of the antioxidant defence system of the body, and therefore initiate the oxidative damage. Targeting the origin of the pathology by stopping the free ... See full document
22
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... SHG-44 cells, by using 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2H-tetrazolium bromide assay, Hoechst 33258 nuclear staining, Annexin V/propidium iodide double staining, as well as western blot ...SHG-44 ... See full document
35
ERK/Nrf2 pathway activation by caffeic acid in HepG2 cells alleviates its hepatocellular damage caused by t butylhydroperoxide induced oxidative stress
... PD98059 followed by treatment of CA suggesting that CA protects HepG2 cells against t-BHP-induced oxida- tive stress by activating Nrf2/ERK ...however, cells treated with CA ...h ... See full document
10
Mouse models of atherosclerosis: a historical perspective and recent advances
... of oxidative stress, endoplasmic reticulum stress and mitochondrial dysfunction in promoting neointimal proliferation has been intensively studied ... See full document
6
Biological mechanisms of gold nanoparticle radiosensitization
... oxidative stress causing necrotic cell death (Pan et ...inside cells inhibiting endogenous reducing agents from acting and therefore reduce the redox capacity of the cells (Pan et ...promote ... See full document
109
Potential therapy strategy: targeting mitochondrial dysfunction in sepsis
... and mitochondrial biogenesis that is viral for sepsis recovery ...[13]. Mitochondrial bio- genesis is therefore defined as the process by which cells increase their individual mitochondrial ... See full document
18
Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells
... toma cells were cultured in a six-well plate in triplicates and treated with 10 and 20 µ M Brevilin A for 4 ...the cells were washed with PBS and incubated with DCFH-DA for 30 minutes in the dark accord- ... See full document
6
Molecular mechanism of cardol, isolated from Trigona incisa stingless bee propolis, induced apoptosis in the SW620 human colorectal cancer cell line
... (control), (ii) cardol at 8 μg/mL, (iii) cardol at 14 μg/mL and (iv) doxorubicin at 1.01 μg/mL (positive control) and incubated for 2, 4, 6 and 24 h. After the indicated time, the media was removed, cells were ... See full document
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