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Abnormal motor phenotype at adult stages in mice lacking type 2 deiodinase.
... altered in D2KO mice. Our results showed that mice with D2 deficiency can be well discriminated from WT in the basis of data coming from footprint and rotarod ...detected in D2KO ...
ENU mutagenesis reveals a novel phenotype of reduced limb strength in mice lacking fibrillin 2.
... Figure 2. The digit fusion phenotype of the Mariusz ...phenotypes in a single mouse (#4). (B) Hard and soft tissue fusion seen in Mariusz ...P7 mice showing a littermate heterozygous ...
Alterations in Brain Inflammation, Synaptic Proteins, and Adult Hippocampal Neurogenesis during Epileptogenesis in Mice Lacking Synapsin2.
... neuroanatomy in the Syn2 -/- mice at different devel- opmental ...stages. In the epileptogenic stage in 1- and 2-months old mice, we found no differ- ences ...
A cysteine protease inhibitor of plasmodium berghei is essential for exo-erythrocytic development.
... isolated in vitro were injected into naı¨ve mice and were capable of establishing a blood stage infection confirming a recent study in which the entire pbicp gene was deleted ...[31]. In ...
ALFY-Controlled DVL3 Autophagy Regulates Wnt Signaling, Determining Human Brain Size.
... tag in the N-terminus and EGFP in the C-terminus (Fig ...resulted in dynamic aggregate formation [32] of the respective DVL proteins, as could be seen in green puncta in confocal ...
CD73 is a major regulator of adenosinergic signalling in mouse brain.
... enzymes in the different parts of brain in the wt and CD73 deficient mice (Figure ...upregulated in the forebrain of the CD73 deficient ...differences in the ATPase or ADPase activity ...
Expression of Caytaxin protein in Cayman Ataxia mouse models correlates with phenotype severity.
... blots. In vivo staining experiments indicated that the third anti-Caytaxin monoclonal antibody 4E3 might also cross-react with unidentified protein(s) and we therefore did not use this antibody for further ...
Inducible nitric oxide synthase in heart tissue and nitric oxide in serum of Trypanosoma cruzi-infected rhesus monkeys: association with heart injury.
... operates in CCC [4,5]. In this context, high nitric oxide (NO) levels have been shown to be associated with the severity of CCC in chronic chagasic patients ...factor in cell-mediated immunity ...
Absence of endochondral ossification and craniosynostosis in posterior frontal cranial sutures of Axin2(-/-) mice.
... Axin2 2/2 mice have a constitutively active cWnt signaling due to a lack of the internal inhibitor Axin2, which is part of the GSK3b-degradation complex ...investigate in detail potential ...
Ectopic cerebellar cell migration causes maldevelopment of Purkinje cells and abnormal motor behaviour in Cxcr4 null mice.
... P1 mice (n = 8 for WT and 7 for ...decrease in Neurog2 (fold- change = ...development in mice and humans Figure ...migration in the developing ...cells in P9 KO ...KO mice ...
Systemic delivery of recombinant brain derived neurotrophic factor (BDNF) in the R6/2 mouse model of Huntington's disease.
... immunolabeling in CALB positive projection striatal neurons was calculated in each of three ...fields, in each of three rostrocaudally spaced sections on each hemisphere of 6 mice from each ...
The role of histamine in the retina: studies on the Hdc knockout mouse.
... anomalies in Hdc 2/2 mice [10, 20, ...Hdc 2/2 mice lack histamine using antisera specific to histamine in brain sections containing the tuberomammillary nucleus as ...
Schmallenberg virus infection of adult type I interferon receptor knock-out mice.
... and, in severe cases, apathy and ...death in at least two mice. Hemorrhages occur through abnormal function of blood vessels ...examined in greater detail; similar observations ...
Tolerance of spermatogonia to oxidative stress is due to high levels of Zn and Cu/Zn superoxide dismutase.
... SOD in testis by Western blot analysis using the recombinant eel Cu/Zn SOD protein we have synthesized by cell-free protein synthesis system [50] and found that this antibody specifically detect eCu/Zn SOD ...
Lef1 haploinsufficient mice display a low turnover and low bone mass phenotype in a gender- and age-specific manner.
... +/ 2 and Gsk3b +/ 2 mice and their controls, all on a C57BL/ 6 background, were generated by breeding Lef1 +/ 2 [36] or Gsk3b +/ 2 [26] mice with C57BL/6 mice from either ...
Repeated 6-Hz Corneal Stimulation Progressively Increases FosB/ΔFosB Levels in the Lateral Amygdala and Induces Seizure Generalization to the Hippocampus.
... aimed at evaluating the changes in seizure phenotype and neuronal network activation caused by a modified 6-Hz corneal stimulation model of psy- chomotor ...seizures. Mice received up to 4 ...
Regulation of synaptic nlg-1/neuroligin abundance by the skn-1/Nrf stress response pathway protects against oxidative stress.
... Finally, in order to test whether neuronal activity regulates SKN-1 in the nervous system, we examined mutants with increased synaptic activity (dgk-1/diacylglycerol kinase or goa-1/Gao) and mutants with ...
Abnormal Motor Activity and Thermoregulation in a Schizophrenia Rat Model for Translational Science.
... part in the development of hyperthermia, and its enhanced variability and decreased asymmetry observed in the new substrain [32]; however, further experiments are required to reveal the possible changes ...
Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease.
... mutations in a-syn (A53T, A30P and E46K) are linked to autosomal dominant PD; thus implicating its role in the pathogenesis of ...PD. In both PD patients and mouse models, there is increasing ...
Efeito do diabetes tipo 1 na neoformação óssea em defeitos críticos em fêmur de camundongos : relevância dos receptores b1 das cininas
... manifests in childhood or adolescence, but a series of complications allied to long-term glucose variations are present in the adult life, making the disease a continuous challenge ...underlying ...