[PDF] Top 20 La responsabilidad social corporativa de las multinacionales españolas en Colombia
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Small Molecules Targeting c-Myc Oncogene: Promising Anti-Cancer Therapeutics
... of c-Myc through combining with G-quadruplexs of Pu27 ...and anti-parallel types, with the ratio of 1:4 at a saturated condition ...a promising agent as a lead compound for a novel an- ... See full document
20
Advances in antibody therapeutics targeting small-cell lung cancer
... of small-cell lung cancer (SCLC) among all lung cancers decreased from ...shown promising prospects against ...the anti-IGF-1R monoclonal antibody figitumumab has a potential therapeutic ... See full document
9
<p>MET Oncogene in Non-Small Cell Lung Cancer: Mechanism of MET Dysregulation and Agents Targeting the HGF/c-Met Axis</p>
... lung cancer (NSCLC) is the leading cause of cancer-related death worldwide and has a poor ...a promising therapeutic ...of c-Met are associated with poor prognosis in lung ...trials, ... See full document
15
Expression of c-myc is not critical for cell proliferation in established human leukemia lines
... structures targeting ap- parently accessible regions in other mRNAs were still highly active ...of c- myc mRNA was obviously readily accessible since it was efficiently cleaved by RNase H in the ... See full document
14
Celecoxib inhibits proliferation and survival of chronic myelogeous leukemia (CML) cells via AMPK-dependent regulation of -catenin and mTORC1/2
... Activation of AMPK seems to precede mTORC1 and mTORC2 inhibition, restoration of GSK3β activity, β-catenin down-regulation and the impairment of CML cell proliferation. Accordingly, partial knock-down of AMPKα expression ... See full document
83
MiR-145 inhibits oral squamous cell carcinoma (OSCC) cell growth by targeting c-Myc and Cdk6
... regulates c-Myc and its target gene cyclin D1, as sup- ported by the findings in other cancers that miR-145 represses the expression of c-Myc and its downstream tar- gets in colon ... See full document
40
“A ROLE OF TEC, A NON RECEPTOR TYROSINE KINASE AS APOPTOTIC REGULATOR” by Khushbu Patel*, Jayvadan K. Patel, Anita Patel, Aaishwarya Deshmukh, Bharat Mishra, India.
... PH domain binds with number of phospholipids by phospholipase C-γ and form a phosphatidylinositol-4, 5- bisphosphate [PI (4, 5) P2] at high affinities in vitro. The Btk PH domain associate with ... See full document
8
DNA Methylation Mediated Downregulation of miR-449c Controls Osteosarcoma Cell Cycle Progression by Directly Targeting Oncogene c-Myc
... moreover, c-Myc is usually overexpressed in different cancer types, such as liver, breast, lung and prostate cancers ...of c-Myc in cancer cells can result in constitutive ... See full document
10
Proteins, which are upregulated at early time points following Apc deletion, are involved in intestinal tumourigenesis and represent potential colorectal cancer biomarkers
... the small intestine ...in small intestine ...the small intestine [92, ...proximal small and large intestine (duodenum and caecum respectivley) ... See full document
5
Targeting p53 by small molecules in hematological malignancies
... other anti-cancer agents to achieve better anti-tumor activity than ...the small molecules in combination with current chemotherapeutics for the treatment of chemorefractory ... See full document
59
Isolation and characterization of c-myc, a cellular homolog of the oncogene (v-myc) of avian myelocytomatosis virus strain 29.
... 773-779 0022-538X/82/060773-07$02.00/0 Isolation and Characterization of c-myc, a Cellular Homolog of the Oncogene v-myc of Avian Myelocytomatosis Virus Strain 29 The chicken genome cont[r] ... See full document
19
A moving target: structure and disorder in pursuit of Myc inhibitors
... The Myc proteins comprise a family of ubiquitous regulators of gene expression implicated in over half of all human ...of Myc proteins, which adopt a defined conformation only in the presence of binding ... See full document
6
Transcriptional targeting of oncogene addiction in medullary thyroid cancer
... of MYC in the MZ-CRC-1 cells compared with ...in MYC-dependent cancer cells (55); thus, if the effect of BRD4 inhibition occurs in part through MYC in the MTC cells, then this also could be a ... See full document
10
Development of small-molecule therapeutics and strategies for targeting RAF kinase in BRAF-mutant colorectal cancer
... Notes: (A) The inactive RAF is a monomer, and the kinase domain has the characteristic N-lobe and C-lobe linked by a hinge. The positioning of the αC helix of N-lobe maintains its “OUT” conformation, and the AS ... See full document
71
CANCER DIAGNOSIS AND THERAPEUTICS: NEWER PROMISING AVENUES OFFERED BY NANOTECHNOLOGY
... Current imaging methods like computed tomography [CT] imaging, magnetic resonance imaging [MRI], positron emission tomography [PET] are restricted in spectrum range, penetration depth, cell targeting, and ... See full document
5
Breast cancer: Small molecules targeting apoptosis, a prospective approach to safe scientific success
... and anti-apoptotic factors was tested and it revealed that curcumin induced apoptosis with an increase in p53 level in MCF-7 cell ...several small molecules have been identified ...in cancer ... See full document
130
Targeting lactate metabolism for cancer therapeutics
... Unexpectedly, a recent report of a mouse model of B cell lym- phoma (λ-Myc transgenic mice) suggested that LDHA is dispens- able for the initiation and progression of lymphoma (47). This finding was particularly ... See full document
85
Application of liposomes in drug development – focus on gastroenterological targets
... formulating therapeutics in PEGylated liposomes functionalized with active targeting molecules (such as antibodies, growth factors, peptides, carbohydrates, lipoproteins, etc) for targeted tissue ... See full document
176
The Evi5 oncogene promotes laryngeal cancer cells proliferation by stabilizing c-Myc protein
... Total RNA of tissues or cell lysates were extracted by using TRIzol reagent (Invitrogen, Shanghai). The cDNA was synthesized by using PrimeScript RT reagent Kit (TaKaRa, Dalian, China), quantitative real-time PCR was ... See full document
26
Changes in the phenotype of human small cell lung cancer cell lines after transfection and expression of the c myc proto oncogene
... lung cancer growing in cell culture possesses biologic properties that allow classification into two categories: classic and ...classic small cell lung cancer cell lines, variant lines have altered ... See full document
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