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A Systems and Synthetic Biology Framework for Regulatory Systems
... With these insights, this work offers a mechanistic understanding of inorganic phosphate intake, realised by Pho regulon in a way that connects signalling with the genetic level. It provides a quantitative description of ... See full document
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Genetic Control of T Cell Proliferation with Synthetic RNA Regulatory Systems
... switch systems improve the ligand-responsive dynamic range for the majority of constructs tested (Figure ...model systems due to HEK cells’ limited tolerance for the small-molecule ligands used, the ability ... See full document
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Computational Programming for Product Designing in Synthetic Biology
... genetic regulatory systems as well as outlined the basic features of synthetic biology as a new engineering discipline ...biological systems has been simplified by constructing ... See full document
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The path to next generation biofuels: successes and challenges in the era of synthetic biology
... operon-specific regulatory mechanisms, referred to here as sugar-utilization regulatory systems ...exerts regulatory control on intracellular level of cAMP, which is an allosteric effector ... See full document
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Modelling gene regulatory networks: systems biology to complex systems
... identical systems provided with similar inputs may produce different outputs as a result of stochastic elements of their regulatory ...gene regulatory networks has been driven in part by the ... See full document
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Inferences of Transcriptional and Translational Regulatory Modules for Systems Biology: A Review
... computation framework also implies that the integration of information is distributed across the network in large and diffuse structures with well-defined functional ... See full document
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Stem cell biology meets systems biology
... and systems biological approaches for achieving a better understanding of stem cell behaviour and ...cell biology was illustrated by the fact that half of all the conference talks contained theoretical ... See full document
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Ecology meets cancer biology: The cancer swamp promotes the lethal cancer phenotype
... and regulatory mechanisms as well as inappropriate host cell recruitment and activity that lead to the death of the ...the framework of ecological biology: multiple interacting ecosystems (organ ... See full document
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Synthetic biology, concerns and risks: looking for a (constitutionally oriented) regulatory framework and a system of governance for a new emerging technology
... a regulatory framework and a model of governance for addressing the risks and concerns arising within synthetic biology ...about synthetic biology, drafted by the ...of ... See full document
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Cell-Free Synthetic Biology Platform for Engineering Synthetic Biological Circuits and Systems
... of synthetic in vitro circuits to control nucleic acid nanorobots for in vivo applications ...RNA Regulatory Circuits for Cell-Free Synthetic ... See full document
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Evolutionary tinkering vs. rational engineering in the times of synthetic biology
... formalisms supplied by engineering. Functions and biological modules that constituted an evolutionary innovation to solve a problem were most successful when they were later assimilated into another context in response ... See full document
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Bio-succinic acid production: Escherichia coli strains design from genome-scale perspectives
... addition, systems and synthetic biology tools are becoming more available to make microorganisms of interest tractable to genetic manipulations within shortest possible ...in synthetic ... See full document
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Synthetic Biology and the Search for Alternative Genetic Systems: Taking How-Possibly Models Seriously
... like synthetic biology can be used to explore the space of biological possibilities by taking established how-actually models for biological systems as a starting point, and then working towards ... See full document
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Interactomes, manufacturomes and relational biology: analogies between systems biology and manufacturing systems
... show some metabolic closure. To a first order, life is a complex self-replicating chemi- cal network enclosed in a self-synthesized membrane that allows specific external molecular substrates to enter the network and ... See full document
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Synthetic Biology: Engineering Complex Biological Systems (EuroSYNBIO)
... Synthetic biology unites multidisciplinary efforts directed at the design of complex biologi- cal systems to obtain useful novel properties and activities based on the exploitation of ... See full document
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A Categorical Approach to Model Formation of Reactive Autonomic Systems Framework
... software systems, researchers involve in building systems with ...reactive systems with autonomic behaviors could be more self- managed and more adaptive to the ...such systems are not ... See full document
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Quantum Genetics, Quantum Automata and Quantum Computation
... systems, n-categories and Topoi of Lukasiewicz Logic Algebras and Intuitionistic Logic (Heyting) Algebras for modeling nonlinear dynamics and cognitive processes in complex neural networks that are present in the ... See full document
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Towards in situ Single Cell Systems Biology
... Imaging gene expression levels with single-cell resolution in intact tissues is essential for understand- ing the genetic programs in many systems, such as developing embryos and dynamic brain circuits. ... See full document
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Integrating Reactive Systems Design in Systems of Systems Framework
... system that existed at build N. Thus, a new functional system is delivered at each build, rather than obtaining build N+1 from build N by adding a new module. The enhancements to be made to obtain a future system are not ... See full document
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Full Article
... Risk Propagation Modeling (RPM): Education and research concepts were organized around the principles of Risk Propagation Modeling 21 . RPM provides an analytical framework through which impact endpoints are ... See full document
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