[PDF] Top 20 El sistema de transferencias a los municipios de la provincia de Buenos Aires
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The CB1 cannabinoid receptor agonist reduces L-DOPA-induced motor fluctuation and ERK1/2 phosphorylation in 6-OHDA-lesioned rats
... precursor L-3,4-dihydroxyphenylalanine (L-DOPA) has been used as an effective drug for treating dopamine depletion-induced Parkinson’s disease ...of L-DOPA produces motor ... See full document
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GABA Attenuates L DOPA Induced Striatal and Nigral ERK1/2 Signaling in a Rat Model of Parkinson’s Disease
... in L-DOPA-induced motor side effects, but according to the present results, the effect of GABA may be the ...with L- DOPA treatment due to its centrality to basal ganglia ... See full document
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Dopamine and GABA Interaction in Basal Ganglia: GABA A or GABA B Receptor Stimulation Attenuates L DOPA Induced Striatal and Nigral ERK1/2 Signaling in a Rat Model of Parkinson’s Disease
... is L-DOPA, but side effects such as dyskinesias limit its ...that L-DOPA treatment induces extracellular signal-regulated kinase (ERK1/2), a MAP-kinase ...unilaterally ... See full document
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High hopes for cannabinoid agonists in the treatment of rheumatic diseases
... Enthusiasm for cannabinoids as medicines seems to go through phases. Firstly, it was thought of as a recreational drug; then potential medicinal benefits emerged and later as the widespread (approaching pleiotropic) ... See full document
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Renal Cannabinoid Receptor Expression and Function: Their Role in Obesity and Diabetes
... the CB1 blockade (Janiak et ...Zucker rats is induced by a mutation to the leptin receptor, which impairs feeding behaviour, thus obese fa/fa Zucker rats exhibit significant hyperphagia ... See full document
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Effects of the cannabinoid CB1 agonist ACEA on salicylate ototoxicity, hyperacusis and tinnitus in guinea pigs
... mg/kg) 2 h before repeating the above recordings, with ACEA administered 20 min before these recordings ( “ salicylate þ ACEA ” , 1 mg/kg, pre- dissolved in anhydrous ethanol at 5 mg/ml; n ¼ 5; Tocris, Bristol, ... See full document
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Jacob, Wolfgang (2007): Role of the Cannabinoid Receptor Type 1 (CB1) in Synaptic Plasticity, Memory and Emotionality. Dissertation, LMU München: Fakultät für Biologie
... of CB1 on trial two with our mouse lines but see the opposite effect namely that total- CB1-ko and Glu-CB1-ko mice reveal an anxiogenic phenotype if the number of mice not exploring the open arms at ... See full document
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The Effects of Crocin on 6-OHDA-Induced Oxidative/Nitrosative Damage and Motor Behaviour in Hemiparkinsonian Rats
... However, Parkinson's disease is a multifactorial neurodegenerative disease and nitrergic mechanisms could also contribute to the dopamine neuronal death seen in PD (48). The administration of 6-OHDA induces ... See full document
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Pharmacodynamics of cannabinoids
... The pharmacodynamic interactions may occur if some of the components have the same or at least similar in luence on activities of the endocannabinoidome receptors. In the pharmacokinetic interactions, some of the plant ... See full document
6
Use of [18F]FDOPA-PET for in vivo evaluation of dopaminergic dysfunction in unilaterally 6-OHDA-lesioned rats
... each 6-OHDA-lesioned group except the control was used for TH immunohis- tochemistry at 12 to 13 weeks after ...lesioning. Rats were deeply anesthetized with pentobarbital and perfused ... See full document
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Measuring dopaminergic function in the 6-OHDA-lesioned rat: a comparison of PET and microdialysis
... super-ODS, 2-μm silica particles, 110-Å pores, 2-mm ...water, 6 g sodium acetate, 40 mg ethylenediaminetetraacetic acid (EDTA), 4 mg sodium dodecyl sulfate (SDS), and glacial acetic acid (to pH ...a ... See full document
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Chronic, intermittent treatment with a cannabinoid receptor agonist impairs recognition memory and brain network functional connectivity
... Brains were coronally sectioned in a cryostat (-20ºC) at 20 µm. Three consecutive sections were retained from every 60 µm and dried rapidly onto slide covers on a hot plate (70ºC). Autoradiograms were obtained by placing ... See full document
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Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis
... Fibrosis is a highly prevalent, multifactorial, and progressive pathogenic process affecting many organs, including the lungs (1). Pulmonary fibrosis (PF) is a life-threatening disease that may benefit from simul- ... See full document
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Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251
... The decrease in STAT3 activation by Ad-bFGF-siRNA can induce multiple effects in glioma cells U251. Our results showed the STAT3 downstream factor CyclinD1 was diminished (Figure 2B). Since we observed no cell cycle ... See full document
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Antagonism of cannabinoid receptor 2 pathway suppresses IL-6-induced immunoglobulin IgM secretion
... lymphoma 6 (Bcl-6), B lymphocyte-induced maturation protein 1(Blimp-1), and paired box 5 factor (Pax5) form- ing the core of the network ...Bcl- 6-/- mice have elevated antibody response and ... See full document
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The use of cannabinoids in animals and therapeutic implications for veterinary medicine: a review
... the cannabinoid recep- tors and their endogenous ligands, definition of the endocannabinoid system and description of other cannabinoid substances elicited increased interest in this research and in the ... See full document
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Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis
... endogenous peroxidase reactions, sections were pre- treated with 0.6% H 2 O 2 . The rat-anti-mouse-BrdU anti- body (Harlan Seralab) was diluted 1:500 in TBS supple- mented with 0.1% TritonX-100, 0.1% Tween ... See full document
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Levodopa/benserazide microspheres reduced levodopa-induced dyskinesia by downregulating phosphorylated GluR1 expression in 6-OHDA-lesioned rats
... for 2 hours at room temperature, and incubated with primary antibodies corresponding to GluR1 (1:500) (Millipore, MA), pGluR1S831 (1:250) (Millipore), or pGluR1S845 (1:250) (Millipore) at 4 ° C ... See full document
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Effects of a Unilateral Injection of Botulinum Neurotoxin Subtype-A in the Subthalamic Nucleus of a Parkinsonian Rat Model
... using 6-OHDA are ...bilaterally lesioned rats develop severe adipsia and aphagia 78 ...bilaterally lesioned animals is possible but there are high mortality rates and animals require ... See full document
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Targeting the D1-N-methyl-D-aspartate receptor complex reduces L-dopa-induced dyskinesia in 6-hydroxydopamine-lesioned Parkinson’s rats
... in 6-hydroxydopamine (6-OHDA)-lesioned PD rat model that intrastriatal injection of Tat-D1-t2 alleviated dyskinetic behaviors and downregulated the phosphorylation of DARPP-32 at Thr34 ... See full document
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