[PDF] Top 20 Las Spin-offs universitarias en Andalucía: un estudio de situación

... effective treatment regimen cannot otherwise be provided’ ...failing treatment and was infected with a highly resistant organism ...Pediatric Drug-Resistant Tuberculosis has pro- ... See full document

... been advances in the understanding of the genetic basis of drug- resistant ...Mycobacterium tuberculosis, the possibility of new targets for drug development has emerged ...the ... See full document

... anti- tuberculosis drug resistance surveillance data. Drug Resist Updat ...Shortening Treatment for Tuberculosis — Back to Basics N Engl J Med 2014; 371:1642-1643 October 23, ... See full document

... recommendations in 2013 this conservatism was understand- able, it may be unnecessarily restrictive in 2015 considering both the accumulated experience with these drugs since then (and specifically with extended use of ... See full document

... M. tuberculosis strains that have acquired resistance to two im- portant drugs in the first-line regimen: rifampicin and isoniazid (Sharma ...Extensively drug-resistant TB (XDR-TB) occurs when M. ... See full document

... the treatment, the child was doing well and was able to produce a good sputum sample; he was discharged 4 months after the initiation phase with con- secutively negative monthly sputum controls (Table ...of ... See full document

... A data extraction form was developed and used to guide the extraction of data from the included studies. First author name, publication year, duration of study, type of study design, control group present, country of ... See full document

... Extremely Drug Resistant TB (XDR-TB), a form of Multi Drug Resistant TB where the ...M. Tuberculosis is resistant not only to the first line anti TB agents but also to the second ... See full document

... Similarly, hepatotoxicity is a significant concern with TB treatment as three of the four first-line agents (rifampicin, isoniazid and pyrazinamide) show significant hepatotoxicity. There are no published ... See full document

... the treatment is difficult, expensive, and a major health care cost burden to devel- oping countries ...incomplete treatment, and patient non-compliance dur- ing treatment of susceptible TB [5, ... See full document

... Mycobacterium tuberculosis is transmitted through the air and infects about one-third of the world’s ...have drug-resistant strains that defy treatment 1 ...Nowadays, tuberculosis (TB) ... See full document

... of drug resistance. In this study a history of previous TB treatment and being smear positive were found to be as- sociated with the prevalence MDR/RR-TB (p < ... See full document

... to drug combination development evaluates poten- tial compounds sequentially, substituting them individually into the existing ...for tuberculosis drug devel- opment, known as the Critical Path to ... See full document

... QT monitoring and the management of QT prolongation The inclusion in the STREAM regimen of high doses of moxifloxacin, which is known to cause QT prolongation [20], together with the fact that many of the patients would ... See full document

... during treatment three possible mechanisms can result in the selection of drug-resistant mutant strains: treatment with an inadequate number of effective drugs, sub-therapeutic dosing or ... See full document

... of resistant mu- tants could be avoided by using high-dose moxifloxacin ...effective drug was based on in vitro testing, although it has never been properly assessed in humans, and cell and animal models ... See full document

... of tuberculosis by inhalation of infected, a droplet of airborne particles which contain Mycobacterium tuberculosis ...active tuberculosis and epidemic disease human immunodeficiency virus (HIV), are ... See full document

... Mycobacterium tuberculosis develops spontaneous resistance mutants to virtually every drug in ...and drug-resistant organisms emerge. The development of drug-resistant organisms ... See full document

... National Tuberculosis Programme (NTP), its purpose was to reform and coordinate TB services on a national level, in line with DOTS standards of TB ...TB treatment in- volved enhanced adherence support ... See full document

... the Tuberculosis Control Institute of Hunan Province, for the period 2011 to ...2014. Treatment outcomes were assessed for patients diagnosed with MDR-TB (TB resistant to at least isoniazid and ... See full document