[PDF] Top 20 Taylor Edward La Ciencia de La Cultura
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DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD
... on DNA methylation data by filtering out probes with any of the following conditions: (1) Missing methylation beta value in any of the samples, (2) probes on X and Y chromo- some, (3) any probes ... See full document
145
Analysis of aberrant methylation on promoter sequences of tumor suppressor genes and total DNA in sputum samples: a promising tool for early detection of COPD and lung cancer in smokers
... use DNA from sputum samples, for the detection of molecular altera- tions ...aberrant methylation of CDKN2A and MGMT promoter regions in LC (73% and 65%, respectively) and COPD (70% and 65%, ... See full document
6
DNA Methylation Analysis of the COVID-19 Host Cell Receptor, Angiotensin I Converting Enzyme 2 Gene (ACE2) in the Respiratory System Reveal Age and Gender Differences
... Public DNA methylation datasets were downloaded from the Gene Expression Omnibus ...website. DNA methylation data for human isolated cell populations from tissues was obtained from ... See full document
11
Bronchial biopsy specimen as a surrogate for DNA methylation analysis in inoperable lung cancer
... 76 lung cancer patients receiving ...Benign lung tumors such as hamar- toma and localized organizing pneumonia were excluded in this study because their methylation profiling is not ... See full document
5
Genome-wide DNA methylation profiling of non-small cell lung carcinomas
... genome-wide methylation studies in NSCLC have concentrated on specific areas of the genome [30], promoter regions [34-36] or sets of pre-selected candi- date genes ...of DNA methylation in ... See full document
6
Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies
... of lung function or COPD with peripheral blood DNA methylation, possibly due to the heterogeneity of methods used, and even with access to full sets of unpublished results we would ... See full document
57
Evaluation of central and peripheral neuropathy in patients with chronic obstructive pulmonary disease
... gas. COPD has been identified to have multisystem involvement with significant extrapulmonary ...manifestations. Patients with COPD frequently suffer from various comorbidities, such as ... See full document
23
Emerging pharmaceutical therapies for COPD
... emerging COPD therapies (Table 5), with the PDE4 inhibitor roflumilast having been approved by the FDA as a COPD ...of lung epithelial cells, neutrophil elastase production, and macrophage secretion ... See full document
8
Role of <em>p14<sup>ARF</sup></em> and <em>p15<sup>INK4B</sup></em> promoter methylation in patients with lung cancer: a systematic meta-analysis
... OncoTargets and Therapy is an international, peer-reviewed, open access journal focusing on the pathological basis of all cancers, potential targets for therapy and treatment protocols employed to improve the management ... See full document
20
Impact of COPD in patients with lung cancer and advanced disease treated with chemotherapy and/or tyrosine kinase inhibitors
... of COPD and non-COPD patients, as well as the possible prognostic value of this comorbidity over a sample of 2,994 LC nonmicrocytic cases surgically treated in hospitals participating in the ... See full document
22
<em>FAM13A</em> locus in COPD is independently associated with lung cancer – evidence of a molecular genetic link between COPD and lung cancer
... the lung cancer cases and healthy control smokers (P , ...the COPD group (skewed distribution) and no difference exists after log transformation of pack-years (data not ...current smokers in ... See full document
34
An empirically driven data reduction method on the human 450K methylation array to remove tissue specific non-variable CpGs
... Tissues showed similar levels of non-variable CpGs DNAm data from publicly available studies was collected for blood, buccal epithelial cells and placenta (21, 3 and 4 studies, respectively). Meta-analysis of ... See full document
76
Economic evaluation of smoking induced lung diseases treatment and their social impact
... 144 patients who suffered from chronic obstructive pulmonary disease (COPD) and/or asthma with exacerbations has been done (Angelova, ...326 patients who has been hospitalized on three clinical ... See full document
12
Factors associated with lung cancer in COPD patients
... of lung cancer risk in COPD patients, while the use of acetylsalicylic acid was associated with an increased ...risk. COPD represents the third most common cause of death and lung ... See full document
7
Characteristics of elderly patients with COPD and newly diagnosed lung cancer, and factors associated with treatment decision
... poor lung function and could not endure opera- tion, and 6/117 (5%) patients were old or with comorbidities that made them ineligible for ...(20%) patients were older than 75 years; 60 (51%) ... See full document
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Profiling genome-wide DNA methylation
... insights, DNA methylation assays have great potential for applica- tion to different fields, particularly medicine and forensic sciences [119, ...[120–124]. DNA methylation has been applied to ... See full document
10
DNA methylation and cognitive aging
... of DNA methylation and histone modification in regulation of neuronal gene expression and learning, memory and ...of DNA methylation to cognitive function, several laboratories including us ... See full document
48
Peripheral blood methylation profiling of female Crohn’s disease patients
... CD patients [44], with the expression of MIR-223 being tightly regulated through histone acetyl- ation and DNA methylation by the AML1/ETO fusion protein, making it an interesting target for future ... See full document
11
Epigenome-wide DNA methylation regulates cardinal pathological features of psoriasis
... aberrant DNA methylation reversed to normal ...of DNA methylation in regulating these crucial histopathologic features, we investigated the genome-wide DNA methylation profile of ... See full document
27
Increased IFN-γ-producing Th17/Th1 cells and their association with lung function and current smoking status in patients with chronic obstructive pulmonary disease
... with COPD were stable and had no exacerbations for ≥3 months prior to ...restrictive lung diseases, other chronic systemic inflammatory diseases, such as rheumatoid arthritis (RA), inflammatory bowel ... See full document
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