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Molecular Diagnostic Methods for Multidrug Resistance in Tuberculosis: A Review
... rapid molecular diagnostic facilities to 628 ...a molecular test is sufficiently simple and robust to be introduced and used outside conventional laboratory ...M. tuberculosis as well as ... See full document
8
MULTIDRUG RESISTANCE BY MICROORGANISMS: A REVIEW
... gonorrhea, tuberculosis, wound infections, and diseases that have become difficult to treat with antibiotics remains an increasing public health problem (WHO, ...developing resistance, as well as due to ... See full document
18
Multidrug Resistance in Tuberculosis: An Overview
... M. tuberculosis pncA gene by Scorpio et ...M. tuberculosis resistant to ...PZA resistance globally is largely ...PZA resistance is common amongst drug-resistant clinical M. tuberculosis ... See full document
154
Genetic Mimetics of Mycobacterium tuberculosis and Methicillin Resistant Staphylococcus aureus as Verification Standards for Molecular Diagnostics
... The work presented here demonstrates that M. smegmatis-derived strains can be used as surrogates for diagnostic assays that make use of NAAT technology, such as GeneXpert MTB/RIF and Hain LPA. These strains are ... See full document
52
gyrA Gene Mutation Conferring Phenotypic Cross Resistance among Fluoroquinolones (Ofloxacin, Levofloxacin and Gatifloxacin) in Multidrug Resistant Mycobacterium tuberculosis Strains Isolated from Pulmonary MDR TB Patients in Bangladesh
... phenotypic resistance to any of the FLQs ...M. tuberculosis test only at the critical concentration recommended for that specific testing ...testing methods. However, molecular assays can ... See full document
87
High resolution melting analysis for molecular detection of multidrug resistance tuberculosis in Peruvian isolates
... of multidrug-resistant strains is a major health prob- ...were multidrug-resistant tuberculosis (MDR-TB) ...as resistance to rifampicin and isonia- zid, two of the first-line anti-TB drugs ... See full document
41
Diagnostic Accuracy and Utility of FluoroType MTBDR, a New Molecular Assay for Multidrug Resistant Tuberculosis
... M. tuberculosis complex, the FluoroType result was compared to the presence or absence of the TUB band from the MTBDRplus result obtained for the corresponding cultured ...isoniazid resistance, the ... See full document
99
Sequence Analysis of Fluoroquinolone Resistance Associated Genes gyrA and gyrB in Clinical Mycobacterium tuberculosis Isolates from Patients Suspected of Having Multidrug Resistant Tuberculosis in New Delhi, India
... WHO-endorsed molecular test. This diagnostic tool may be used for the detection of MDR-TB (resistance to both RIF and INH) directly on smear-positive sputum samples or, if samples are smear negative, ... See full document
50
Lab on Chip Based Platform for Fast Molecular Diagnosis of Multidrug Resistant Tuberculosis
... form includes a temperature control system (TCS) and an optical reader (OR) which allows automatic analysis of the microarray, pro- viding a user-friendly diagnostic report (see Fig. S2 in the supplemen- tal ... See full document
60
Drug resistance of Mycobacterium tuberculosis in Malawi: a cross-sectional survey
... MDR tuberculosis among new or retreatment ...MDR tuberculosis in people undergoing retreatment was found to be significantly and inversely associated with time since previous treatment (adjusted IRR: ...MDR ... See full document
14
Comparison of laboratory costs of rapid molecular tests and conventional diagnostics for detection of tuberculosis and drug resistant tuberculosis in South Africa
... (BD Diagnostic Systems, Sparks, MD, USA), indirect phenotypic DST using the MGIT SIRE system (BD Diagnostic Systems), and anti-MPB64 monoclonal antibody-based species identification (Capilia TB-Neo, TAUNS ... See full document
5
<p>A Review of Research Progress in Multidrug-Resistance Mechanisms in Gastric Cancer</p>
... Tumor cells could reduce the level of drugs ’ targets or enzymes ’ activity in cells to induce drug resistance. DNA topoisomerase is served as drug targets by many commonly used chemotherapeutics, such as ... See full document
25
Optimising molecular diagnostic capacity for effective control of tuberculosis in high burden settings
... Optimising molecular diagnostic capacity for effective control of tuberculosis in high burden settings.. University of St.[r] ... See full document
120
LRIG1 Enhances Chemosensitivity by Modulating BCL 2 Expression and Receptor Tyrosine Kinase Signaling in Glioma Cells
... Fig. 4. BCL-2 knockdown reverses MDR in U251/MDR cells. U251/MDR cells at 50% confluence were transfected with siBCL-2 (2 mg/well, 6-well plate) using the Lipofectamine 2000 transfection reagent (Invitrogen) according to ... See full document
11
Drug resistance profiles and trends in drug-resistant tuberculosis at a major hospital in Guizhou Province of China
... leading cause of death and the leading cause of death from infectious diseases in the world, and drug-resistant TB can occur when appropriate anti-TB drugs are not prescribed or are taken incorrectly in both the public ... See full document
12
Pulmonary Tuberculosis in Morocco: A Two Year Retrospective Study
... of tuberculosis are diagnosed and nearly 2 million people die from the disease around the world ...HIV). Tuberculosis can be treated with an early diagnosis and adequate treat- ment ...of ... See full document
15
Predominant Mycobacterium tuberculosis Families and High Rates of Recent Transmission among New Cases Are Not Associated with Primary Multidrug Resistance in Lima, Peru
... DNA fingerprint analysis. Basic strain classification in phylogenetic families was performed using the MIRU-VNTRplus server (22, 33). To determine the spoligotype family (26), patterns were compared with those in the ... See full document
146
Prevalence of extended-spectrum beta lactamase positive and multidrug resistance pattern of Escherichia coli and Klebsiella pneumoniae isolates, Semnan, Iran
... From the 382 specimens isolated from urine (n=256), stool (n=109), sputum (n=13), and blood (n=4), 275 (72%) were Escherichia coli, and 107 (28%) were K. pneumoniae positive. Using the disk diffusion method, ... See full document
5
High imatinib dose overcomes insu cient response associated with ABCG2 haplotype in chronic myelogenous leukemia patients
... MMR at 18 months is also part of the “optimal response” defi nition of the ELN2009 recommendation for CML patient management [32]. We thus selected cumulative incidence of major molecular response (CI-MMR) as a ... See full document
10
Comparing multidrug resistant tuberculosis patient costs under molecular diagnostic algorithms in South Africa
... Comparing multidrug-resistant tuberculosis patient costs under molecular diagnostic algorithms in South ...of tuberculosis and lung disease, 19 ... See full document
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