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(1)

Id name G1 G2 G3 G4 H1

b0721  sdhC 64 72 61 50 485

b3603  lldP 54 24 32 13 226

b3761  trpT 8 16 16 11 94

b3749  rbsA 64 19 33 43 303

b4425  rttR 10 9 9 6 48

b0988  insB1 5 4 15 8 40

b3088  alx 285 103 174 168 1144

b3672  ivbL 47 62 56 38 355

b3748  rbsD 92 40 40 42 384

b1977  asnT 5 7 12 12 37

b0722  sdhD 94 55 85 65 450

b3161  mtr 39 43 28 32 118

b3452  ugpA 27 17 20 16 64

b3687  ibpA 12 12 8 8 89

b4447  sibD 25 81 93 62 361

b4441  glmY 166 309 291 193 1152

b4484  cpxP 348 362 504 480 2393

b3451  ugpE 15 18 17 9 47

b0380  yaiZ 3 10 8 8 35

b3557  insJ 16 7 11 8 36

b4164  glyX 73 119 139 104 610

b1264  trpE 26 28 18 18 56

b0206  aspU 9 9 8 11 54

b0682  chiQ 6 14 11 10 49

b3528  dctA 76 41 41 30 224

b1665  valV 9 10 10 16 56

b2844  yqeF 45 16 19 21 116

b3227  dcuD 22 16 8 6 48

b0723  sdhA 625 241 294 218 1754

b4163  glyV 183 295 287 229 1311

b4567  yjjZ 13 12 12 18 63

b0459  maa 34 40 42 24 129

b3110  yhaO 140 123 105 71 345

b4246  pyrL 399 452 490 438 1896

b0216  aspV 207 223 169 140 588

b3453  ugpB 369 324 449 226 854

b3418  malT 203 108 123 79 556

b1398  paaK 19 17 14 11 52

b3798  leuT 55 89 70 57 266

b4393  trpR 39 41 29 39 132

b4432  ryeA 90 144 153 113 460

b4105  phnD 37 22 45 23 92

b3556  cspA 6053 6985 8202 7280 22443

(2)

b3799  proM 24 34 38 32 115

b1231  tyrT 175 198 198 123 730

b4165  glyY 42 62 55 61 208

b0244  thrW 41 47 49 39 135

b2691  argQ 38 44 41 27 109

b2018  hisL 47 37 33 22 145

b3796  argX 258 417 459 344 1404

b2692  argZ 82 136 127 83 345

b3797  hisR 394 687 642 563 1934

b1892  flhD 169 109 83 88 497

b2816  metV 50 53 81 48 182

b1558  cspF 81 100 117 80 279

b3654  xanP 261 196 216 185 829

b1422  ydcI 103 102 119 95 312

b1230  tyrV 127 86 104 61 301

b4232  fbp 461 432 407 354 1454

b0747  lysY 97 97 94 84 307

b4014  aceB 1013 662 801 603 2708

b3979  thrT 176 208 189 181 672

b0673  metT 590 627 600 494 1924

b2180  yejF 137 126 136 112 345

b1283  osmB 117 95 99 77 268

b4369  leuP 146 175 187 151 509

b0746  valZ 146 135 158 100 375

b2175  spr 535 491 479 415 1409

b0797  rhlE 377 184 236 168 778

b3163  nlpI 4343 3351 3654 2525 8826

b0720  gltA 369 291 359 286 1065

b0748  lysZ 219 156 156 137 478

b3170  rimP 421 395 382 340 1103

b3041  ribB 346 318 371 310 978

b0672  leuW 751 625 740 569 1982

b3977  tyrU 571 454 438 393 1363

b2441  eutB 292 285 321 265 836

b1090  plsX 581 540 552 456 1559

b3704  rnpA 563 337 366 256 1253

b2695  serV 4451 3578 2987 2579 8050

b3162  deaD 3305 2238 3170 1981 7613

b3739  atpI 583 607 540 499 1490

b3357  crp 1120 929 835 781 2571

b2402  valX 628 656 548 499 1606

b0118  acnB 4466 3241 4113 2840 11817

(3)

H2 H3 H4 G1.norm G2.norm G3.norm G4.norm

342 486 404 66 100 84 80

144 200 175 56 33 44 21

59 67 103 8 22 22 18

231 165 269 66 26 45 69

44 42 65 10 12 12 10

44 50 49 5 6 21 13

618 1290 851 294 143 239 268

247 227 286 48 86 77 61

243 230 248 95 55 55 67

45 42 82 5 10 16 19

281 389 416 97 76 117 104

172 140 297 40 60 38 51

86 84 144 28 24 27 26

28 27 54 12 17 11 13

246 270 441 26 112 128 99

928 934 1690 171 428 399 308

1309 2509 1607 359 501 691 766

61 58 104 15 25 23 14

29 32 29 3 14 11 13

40 41 60 16 10 15 13

330 434 537 75 165 191 166

111 70 140 27 39 25 29

30 33 49 9 12 11 18

35 36 56 6 19 15 16

148 172 193 78 57 56 48

38 42 60 9 14 14 26

66 103 107 46 22 26 34

41 46 61 23 22 11 10

912 1298 1240 645 333 403 348

725 797 1110 189 408 394 365

53 41 63 13 17 16 29

105 123 166 35 55 58 38

373 362 490 144 170 144 113

1304 1291 2292 411 625 672 699

539 636 924 213 309 232 223

1138 1098 1827 381 448 616 361

360 402 459 209 149 169 126

47 52 61 20 24 19 18

220 208 301 57 123 96 91

108 116 190 40 57 40 62

377 404 518 93 199 210 180

100 75 179 38 30 62 37

22022 24582 29632 6242 9665 11247 11615

(4)

95 114 121 25 47 52 51

458 525 645 180 274 272 196

138 187 225 43 86 75 97

131 153 163 42 65 67 62

116 109 166 39 61 56 43

98 109 86 48 51 45 35

992 1098 1502 266 577 629 549

327 288 428 85 188 174 132

1586 1687 2279 406 951 880 898

270 251 378 174 151 114 140

150 150 247 52 73 111 77

262 298 309 84 138 160 128

495 503 810 269 271 296 295

287 333 326 106 141 163 152

239 257 303 131 119 143 97

980 997 1548 475 598 558 565

210 224 360 100 134 129 134

1668 2010 2370 1045 916 1098 962

387 403 737 181 288 259 289

1241 1381 1842 608 868 823 788

308 326 388 141 174 186 179

207 207 364 121 131 136 123

356 380 565 151 242 256 241

291 302 439 151 187 217 160

1061 1137 1386 552 679 657 662

495 495 656 389 255 324 268

7800 7739 10911 4479 4637 5011 4029

620 791 902 381 403 492 456

357 355 515 226 216 214 219

818 840 1215 434 547 524 542

696 682 1173 357 440 509 495

1462 1414 2029 774 865 1015 908

834 1016 1521 589 628 601 627

631 566 987 301 394 440 423

1112 1060 1691 599 747 757 728

710 692 1125 581 466 502 408

6162 7573 12185 4590 4951 4096 4115

5089 5770 8043 3408 3097 4347 3161

1220 1196 1632 601 840 740 796

1689 1952 2861 1155 1286 1145 1246

1233 1221 1707 648 908 751 796

6371 7830 9861 4605 4485 5640 4531

(5)

H1.norm H2.norm H3.norm H4.norm A‐notAttache A‐attached FC

311 300 447 238 324 82 0.254000235

145 126 184 103 140 38 0.2750952214

60 52 62 61 59 17 0.298276305

194 202 152 159 177 52 0.291606489

31 39 39 38 37 11 0.305473945

26 39 46 29 35 11 0.316603240

733 542 1185 502 741 236 0.318368921

227 216 209 169 205 68 0.330798432

246 213 211 146 204 68 0.333153189

24 39 39 48 38 13 0.336009188

288 246 357 245 284 98 0.345754819

76 151 129 175 133 47 0.356760423

41 75 77 85 70 26 0.374529664

57 25 25 32 35 13 0.381326528

231 216 248 260 239 91 0.381388425

738 813 858 997 852 326 0.383260118

1533 1147 2306 948 1484 579 0.390395501

30 53 53 61 50 20 0.393700540

22 25 29 17 24 10 0.430962885

23 35 38 35 33 14 0.411835573

391 289 399 317 349 149 0.427360060

36 97 64 83 70 30 0.424708471

35 26 30 29 30 13 0.418344540

31 31 33 33 32 14 0.441505697

144 130 158 114 136 60 0.438751596

36 33 39 35 36 16 0.435520336

74 58 95 63 72 32 0.441810318

31 36 42 36 36 16 0.450977772

1124 799 1193 732 962 432 0.449366986

840 635 732 655 716 339 0.473616241

40 46 38 37 40 19 0.465066375

83 92 113 98 96 47 0.4830651234

221 327 333 289 292 143 0.488860255

1215 1143 1186 1352 1224 602 0.491719887

377 472 584 545 495 244 0.493814185

547 997 1009 1078 908 451 0.497069502

356 316 369 271 328 163 0.498090292

33 41 48 36 40 20 0.504559069

170 193 191 178 183 92 0.501104775

85 95 107 112 99 50 0.499937213

295 330 371 306 326 171 0.5239195884

59 88 69 106 80 42 0.520046316

14380 19300 22590 17484 18438 9692 0.525663639

(6)

74 83 105 71 83 44 0.525252358

468 401 482 381 433 231 0.5324027094

133 121 172 133 140 75 0.540153620

86 115 141 96 110 59 0.5403812494

70 102 100 98 92 50 0.539402804

93 86 100 51 82 45 0.546004679

900 869 1009 886 916 505 0.5516402754

221 287 265 253 256 145 0.565289048

1239 1390 1550 1345 1381 784 0.567609900

318 237 231 223 252 145 0.574292020

117 131 138 146 133 78 0.587889605

179 230 274 182 216 127 0.589878738

531 434 462 478 476 283 0.594033601

200 252 306 192 237 141 0.591819610

193 209 236 179 204 122 0.5994378334

932 859 916 913 905 549 0.606639955

197 184 206 212 200 124 0.6222361414

1735 1462 1847 1398 1611 1005 0.624164957

431 339 370 435 394 254 0.645910154

1233 1088 1269 1087 1169 772 0.660128284

221 270 300 229 255 170 0.667795822

172 181 190 215 190 128 0.6736543024

326 312 349 333 330 223 0.6739270404

240 255 278 259 258 178 0.691541600

903 930 1045 818 924 638 0.690090688

498 434 455 387 444 309 0.696091418

5655 6836 7112 6438 6510 4539 0.697167659

682 543 727 532 621 433 0.6969367674

306 313 326 304 312 219 0.699785482

707 717 772 717 728 512 0.702851883

627 610 627 692 639 450 0.704444466

1270 1281 1299 1197 1262 890 0.7056239034

873 731 934 897 859 611 0.711629715

536 553 520 582 548 390 0.711252135

999 975 974 998 986 708 0.717522662

803 622 636 664 681 489 0.718305762

5158 5400 6959 7190 6177 4438 0.718486539

4878 4460 5302 4746 4846 3503 0.722822335

955 1069 1099 963 1021 744 0.728789819

1647 1480 1794 1688 1652 1208 0.731006022

1029 1081 1122 1007 1060 776 0.7320253534

7571 5584 7195 5818 6542 4815 0.736042359

(7)

log2FC rawp adjpBH fit1conv fit0conv perGeneDisp fittedDisp

########## 2,00E‐01 2,19E‐12 TRUE TRUE 4,64E‐02 0,0214

########## 5,92E+05 1,73E‐06 TRUE TRUE 7,73E‐02 0,0268

########## 4,89E+04 2,39E‐07 TRUE TRUE 3,19E‐10 0,0395

########## 1,79E+03 1,12E‐07 TRUE TRUE 5,94E‐02 0,0246

########## 7,91E+07 1,23E‐04 TRUE TRUE 3,36E‐10 0,0527

########## 9,40E+09 5,91E‐03 TRUE TRUE 1,21E‐01 0,0543

########## 1,70E+09 1,63E‐03 TRUE TRUE 1,22E‐01 0,019

########## 0 0,00E+00 TRUE TRUE 2,34E‐02 0,0234

########## 3,57E+04 1,96E‐07 TRUE TRUE 4,82E‐02 0,0234

########## 7,37E+08 5,22E‐03 TRUE TRUE 1,02E‐01 0,051

########## 2,22E‐02 3,25E‐13 TRUE TRUE 2,47E‐02 0,0216

########## 5,63E+08 5,89E‐04 TRUE TRUE 7,71E‐02 0,0266

########## 3,71E+08 4,18E‐04 TRUE TRUE 5,19E‐02 0,0349

########## 0.000840745 3,09E‐02 TRUE TRUE 9,33E‐02 0,0527

########## 0.000844590 3,09E‐02 TRUE TRUE 1,82E‐01 0,0224

########## 1,32E+08 1,82E‐04 TRUE TRUE 7,95E‐02 0,0187

########## 0.000463370 2,03E‐02 TRUE TRUE 1,28E‐01 0,018

########## 4,38E+09 3,38E‐03 TRUE TRUE 5,88E‐02 0,0418

########## 0.000950573 3,42E‐02 TRUE TRUE 5,38E‐02 0,0674

########## 0.000259348 1,36E‐02 TRUE TRUE 1,77E‐02 0,0538

########## 2,49E+09 2,14E‐03 TRUE TRUE 7,82E‐02 0,0206

########## 0.001491902 4,68E‐02 TRUE TRUE 9,82E‐02 0,0342

########## 0.000245319 1,30E‐02 TRUE TRUE 4,77E‐10 0,057

########## 0.000238524 1,28E‐02 TRUE TRUE 2,91E‐10 0,0539

########## 5,09E+05 1,60E‐06 TRUE TRUE 1,81E‐02 0,0259

########## 0.0001059254 6,46E‐03 TRUE TRUE 2,22E‐10 0,0502

########## 2,35E+09 2,06E‐03 TRUE TRUE 4,80E‐02 0,0334

########## 0.000367956 1,78E‐02 TRUE TRUE 5,02E‐03 0,0495

########## 4,66E+09 3,53E‐03 TRUE TRUE 7,52E‐02 0,0184

########## 2,31E+08 2,06E‐03 TRUE TRUE 6,14E‐02 0,0188

########## 0.000178085 1,00E‐02 TRUE TRUE 6,63E‐11 0,0459

########## 1,45E+08 1,93E‐04 TRUE TRUE 1,53E‐02 0,0291

########## 1,83E+06 4,47E‐06 TRUE TRUE 2,52E‐02 0,0211

########## 2,58E+05 9,52E‐07 TRUE TRUE 2,76E‐02 0,0181

########## 8,21E+06 1,57E‐05 TRUE TRUE 2,99E‐02 0,0195

########## 0.000480884 2,07E‐02 TRUE TRUE 7,27E‐02 0,0185

########## 2,05E+05 4,74E‐06 TRUE TRUE 2,57E‐02 0,0207

‐0.9869049170.001185765 4,00E‐02 TRUE TRUE 1,84E‐03 0,0457

‐0.996815808 9,47E+07 1,39E‐04 TRUE TRUE 3,33E‐02 0,0234

########## 3,33E+07 3,85E‐04 TRUE TRUE 1,32E‐02 0,0286

‐0.9325826910.000153051 8,84E‐03 TRUE TRUE 5,86E‐02 0,0206

‐0.9432879760.001481837 4,68E‐02 TRUE TRUE 6,09E‐02 0,0311

‐0.927788147 8,33E+09 5,46E‐03 TRUE TRUE 5,46E‐02 0,0173

(8)

‐0.9289173590.000169857 9,68E‐03 TRUE TRUE 4,29E‐02 0,0306

‐0.909410181 7,52E+06 1,50E‐05 TRUE TRUE 2,43E‐02 0,0198

‐0.8885583230.000284737 1,44E‐02 TRUE TRUE 5,00E‐02 0,0251

‐0.887950478 7,76E+09 5,33E‐03 TRUE TRUE 3,38E‐02 0,0273

‐0.890565073 4,96E+09 3,69E‐03 TRUE TRUE 2,19E‐02 0,0291

‐0.8730147790.001370136 4,39E‐02 TRUE TRUE 4,82E‐02 0,0305

‐0.8582003020.000697244 2,76E‐02 TRUE TRUE 6,69E‐02 0,0184

‐0.8229393480.000600669 2,49E‐02 TRUE TRUE 5,53E‐02 0,0214

‐0.8170283400.001588566 4,91E‐02 TRUE TRUE 7,18E‐02 0,018

‐0.800143579 8,86E+08 8,84E‐04 TRUE TRUE 2,48E‐02 0,0215

‐0.7663828240.000277207 1,42E‐02 TRUE TRUE 3,54E‐02 0,0253

‐0.7615096830.001445660 4,60E‐02 TRUE TRUE 4,96E‐02 0,0222

‐0.751383555 1,07E+08 1,52E‐04 TRUE TRUE 3,63E‐03 0,0195

‐0.7567705920.000380367 1,80E‐02 TRUE TRUE 3,61E‐02 0,0217

‐0.738317952 2,72E+09 2,30E‐03 TRUE TRUE 1,11E‐02 0,0224

‐0.721087573 5,57E+07 9,41E‐05 TRUE TRUE 2,98E‐03 0,0184

‐0.684465901 7,99E+09 5,40E‐03 TRUE TRUE 2,35E‐03 0,0225

‐0.680000731 1,55E+08 2,01E‐04 TRUE TRUE 1,17E‐02 0,0179

‐0.6305945930.000201435 1,09E‐02 TRUE TRUE 2,50E‐02 0,0198

‐0.599181679 1,96E+09 1,83E‐03 TRUE TRUE 1,37E‐02 0,0181

‐0.5825210270.000493481 2,07E‐02 TRUE TRUE 1,40E‐02 0,0212

‐0.5699196570.001326830 4,31E‐02 TRUE TRUE 3,90E‐03 0,0226

‐0.5693356810.000362174 1,78E‐02 TRUE TRUE 2,25E‐02 0,0203

‐0.5321120530.001039475 3,68E‐02 TRUE TRUE 7,26E‐03 0,0211

‐0.5351421290.000200420 1,09E‐02 TRUE TRUE 8,42E‐03 0,0183

‐0.5226513050.000724797 2,84E‐02 TRUE TRUE 2,07E‐02 0,0195

‐0.5204224480.000130068 7,72E‐03 TRUE TRUE 8,76E‐03 0,0174

‐0.5209003270.000494162 2,07E‐02 TRUE TRUE 1,78E‐02 0,0188

‐0.5150153590.001362879 4,39E‐02 TRUE TRUE 3,97E‐11 0,0204

‐0.5087074010.0004300014 1,96E‐02 TRUE TRUE 3,98E‐03 0,0186

‐0.5054421160.000461177 2,03E‐02 TRUE TRUE 1,12E‐02 0,0188

‐0.5030286600.000311166 1,55E‐02 TRUE TRUE 5,41E‐03 0,018

‐0.4908013410.000762822 2,91E‐02 TRUE TRUE 5,43E‐03 0,0184

‐0.4915670150.000740534 2,87E‐02 TRUE TRUE 1,16E‐02 0,019

‐0.4789036950.000688183 2,75E‐02 TRUE TRUE 3,89E‐03 0,0182

‐0.4773300050.001070137 3,76E‐02 TRUE TRUE 1,57E‐02 0,0187

‐0.4769669660.000947530 3,42E‐02 TRUE TRUE 1,85E‐02 0,0174

‐0.4682870070.000432119 1,96E‐02 TRUE TRUE 1,47E‐02 0,0174

‐0.4564252870.001117742 3,86E‐02 TRUE TRUE 1,14E‐02 0,0182

‐0.4520448030.001244976 4,17E‐02 TRUE TRUE 4,14E‐03 0,0178

‐0.4500344780.001254245 4,17E‐02 TRUE TRUE 9,19E‐03 0,0181

‐0.4421392980.001311646 4,30E‐02 TRUE TRUE 1,74E‐02 0,0174

(9)

Invert FC

‐3,9512195

‐3,6842105

‐3,4705882

‐3,4038462

‐3,3636364

‐3,1818182

‐3,1398305

‐3,0147059

‐3

‐2,9230769

‐2,8979592

‐2,8297872

‐2,6923077

‐2,6923077

‐2,6263736

‐2,6134969

‐2,5630397

‐2,5

‐2,4

‐2,3571429

‐2,3422819

‐2,3333333

‐2,3076923

‐2,2857143

‐2,2666667

‐2,25

‐2,25

‐2,25

‐2,2268519

‐2,1120944

‐2,1052632

‐2,0425532

‐2,041958

‐2,0332226

‐2,0286885

‐2,0133038

‐2,0122699

‐2

‐1,9891304

‐1,98

‐1,9064327

‐1,9047619

‐1,9023937

(10)

‐1,8863636

‐1,8744589

‐1,8666667

‐1,8644068

‐1,84

‐1,8222222

‐1,8138614

‐1,7655172

‐1,7614796

‐1,737931

‐1,7051282

‐1,7007874

‐1,6819788

‐1,6808511

‐1,6721311

‐1,6484517

‐1,6129032

‐1,6029851

‐1,5511811

‐1,5142487

‐1,5

‐1,484375

‐1,4798206

‐1,4494382

‐1,4482759

‐1,4368932

‐1,4342366

‐1,4341801

‐1,4246575

‐1,421875

‐1,42

‐1,4179775

‐1,405892

‐1,4051282

‐1,3926554

‐1,392638

‐1,3918432

‐1,3833857

‐1,3723118

‐1,3675497

‐1,3659794

‐1,3586708

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