1! " 2 5
!
7
2
( ( 4 ( =
7$ $ . $ !( A+ $ : . ; A.9 D E&.9 0" 9 D& . $ $
. $ % #$ ($ 2# $ %
2!
P 8 P ( 8 P 8 8 9 ( ' (
( ( ( * 8 * P 8 '( 8 ( . 8 (
58( 8 8 '( 8 / ( P 8 9 8 ( ( ' (
' ( 8 '( 8
8 ( % ( 9 8 8 > ( 8 ( 8 8 8 (
((8 8 ( 8> 8 % 8 + 8 8( 8 8 / 8 .
8
5 $ 2 K +
C ! 7
2 L 8 ( 8 / P 8 8 8
, L 9 8 '8( / 8 ' 9
8 8 ( 8 8( M ( 80
5 ( ( ( ACGGWB P 8 , 8 9
P ( %( ( 8 8 9
( * 80
P 8 8 8 ( @ '8 ( 8 = ( 8
8%P 8 8 ( 58( 8 P 8 L (8 . ( F>FEEI D
.8 S 8 8 8P 9 ( / P 8
( 8 FI>FEEW J .8 '8( 9 % (( 8
5( (
(8 :( $ 89 8 8 X
1 8 . '8( 8 '( 8 8 ( 8 P 8 .
'8( 8 8 8 / 8 ( 8 ( *
P 8 8 8 ( 8 8 . 8 8 8 8 '8( 8(
(8'8 8 . ( ((8 8 ( (
* 8 ( 88' ( . ( ' 8 ' ( 8
58( 8 < = (8 5( (
( 8 8 8%P 8 ((8 8 ' ( 8 ( +
8 8 ( . 8( ( ('8 . / 8 8 8
M' 8( . /( '8 % 8 ( ( 8 8
. 8 8 ( ( 8 ' ( 8( = ( '8 %(
'( ( / ' ( % ( / 8
( '8 % * 8 8 . ' ( 8 . ( 8 8 8 8
/ 8 P ( 8 / 8 * . 8 * % 8
'8 ( 8%(
((8 ( . * % 8 ( % P8 9 '8
' 8 8( . ( 9 '( % =
8 8 ( . 8( ( ( / L . '8(
8 8 8 ( 8 ( 8 ( 8
' ( ' ' ( ' 8 8 ' 8(
5( ( P 8 ( 8 ( 8 8 8 ' ( 8 8 (
* 8( . 8 %(
F 2
8 P 8 8 ( <8 . < ' ( ((8 8
' ( 8 . '( = P '8 8 58( 8 = 8 L
'( ' ( ( 8 8( 8 ' ( ( '8 ( 8( 8 9 8
: 8 8 ( ACGGCB 8 9 8
( ' ( + / '( ' ( 8( / / . / /
/ '( ' ( 8( ( = ( /8( (
'( 8 8 ( . 8( = ( 8 ( ' ( 8 '( 8 . '( ' ( (
( % @ . 8
8 8 8%P 8 9 '8 8 8% ( 8 8 8 +
8 ( % ( P8( ( ( 8 8 ( 8
P8( ( 88' ( ( 8
( ' . 8 ( ((8 8 8 P 8
((8 ( % ' ( 8( . % 8(
8 ( % ( P8( ( % P8 9 '8
P8( ( 8 8 8 . 8 (8 '(8' 8 ('8 ( @
/ ( 8 P 8
' ( . 8( ( 8( L '(8'
8 8 ( 8 ' 8 ' ( ( '8
' ( (8 ('8 ( @ * % 8 * @ 8
8 %8( ( 8 8 8 ' < (8
( ' 8 . 8 %8( * ( % P8 8
8 M'8 8 ( P 8 9 ' = (
' ( 8
$ 1! " + 2 2
+ DR
! 2 2+ 5 8 ' 8 8 =8 . =
2 + 2 ( '8( 8 8 '8 ( 8 ( 8 9
( '( 8 8 8 8 > 8( = 9 8
( '( L (8 . ( 8 (8> ( 8 %(
8 . 8 8 > 8(( * ( 8 9 8 ( '(
9 8 (8 2 ( ' 8 8' ( ' @ 8 % (
8 %( 8 ( ( 8(( 8 % @ ' ( (
8 %( 8 . '8( 8 9 8 8 9 8 9
( 8 9 8
" 2+ 8 ' = 8 8 ' ' ( 8 (8 (( 8( 8 8 8 %( 8
K 2+ 8 8 ' % ( '8( ( 8 /( 8 9 ( 8 (
'8 % 9 8
$2 K 2+ P 8 ( 8 ' '8( 8 9
$ 1! " + ! 4 5 Y! 2
+ CR FR . DR
! 2 2+ 5 8 =8 8 8 ' < 8 8 ( '8( 8>
2 + 8 8 > 8 8 '8( ' ( P /( /(
8 8 8 ' < 8 '8( ( ' ( 8 . <
P 8 8 8 > ( (( % ( ' < 8 ' ( P
( 8 8('( ( 8 . ( 8 ( 9
(( % 8 ' < 8
" 2+ 5(8 ( ( 8( 8 8 / 8 '8 % ( 8>
8 8 (8 % ' ( ( 9
K 2+ 5 % ( 8 ( ' 8 L 8
$2 K 2+ 4 . 9 '(8 ( ( 9 8 M ' P8 8 8
8
$ 1! " + " ! ;! K 5 ;!
+ CR FR . DR
! 2 2+ 5 8 8 8
2 + 8 8 > ' ( '8( ' 8 . 8((
* 9 8 < < 8 8 8 8 >
' ( 8 8%P 8 8 ' ( 8 L 8 8 ' < (8
( 8 ( ( 8 ' 8 5 8 '8 <
(8> 8 8 > P ' ( ( . 8(( ( 8
5 ( = ( 8 ( ' 8 9 ' (8
% @ 8 ( %( 8 ' (
" 2+ 5(8* % 8 8 ' ( / ( 8 L 8
K 2+ 5 % ( 8 ( ' 8 L 8
$2 K 2+ % * ( 8 8 > 9 (
8 .8 8%P 8 8 '( 8
$ 1! " + a;! 2 1! `
+ CR FR . DR
! 2 2+ 5 8 8 8
2 + 2 8 ' ( P . 8 8 8 ' ( 8 9
'8 % 8 %( '8( ' 8 < (8> 8
8 8 '8 ' ( P ( P ( . (( ( 8
8 8 ' < (8 > ( ( ' ( 8 * 8 % (( ( 8 8
('8
" 2+ 8 ' ( 8 (( ( '8( 8 9 8 9 8
8 > '8 8 8 '
K 2+ 5 * % ( ' ( P
$ 1! " + $ Y
+ FR . DR
! 2 2+ 5 8 8 8 ( 8 ' < 8 '8( 8>
2 + 2 8> ( 8 ' < 8 9 %
8 8 ( ' ( ( ' . 9 9
8 8 < (8> 8 8 ( 8 ( .8(
L (8 , 8<8 0 ( 8 8 ( ( '(8' 8 5 8 '8
8 ( < ' ( / = ( P 8 . * ( 8 " 8> 9
'8 , 8<8 0
" 2+ 8 8 (( ( ' ( ' ( 9 (8% '(8' 8 8<8
K 2+ 2 ' = ( ' < 8 ( Q
$2 K 2+
$ 1! " + $ S
+ CR FR . DR
! 2 2+ 5 8 8 8
2 + 2 9 * 8%8 . 9 8( (8 8 '8(
' ( P (( 8 8 ' ( P (( ( . 8%8
' ( 8 8( (8 8 8( (8 8 ((
8 ' < (8> 8 9 /8( ' ( P %( 8 . 8 ( 8 8 (8
8 ' < (8> ' ( P 8 8( (8 2 8%8 = 8( (8
% 8 ' '
" 2+ 8 ' ' P ( 8 8 ' < (8 >
K 2+ = 8%8 . 8( (8 ' % ( '8( 9 ( 8 (
'8 % 9 8
$2 K 2+
$ 1! " + 2 2 2
+ CR FR . DR
! 2 2+ 5 8 8 8 . 8 8 8 L 8 9 '
% (
2 + 2 9 9 . 8 8 8(( 8( 2
( < (8> P 8 (( ( . ' (
K ( 8 8 > 8 9 9 ' ( ( 8 ( '8 58 (
( % 8 2 L 8(( 8( ' 8 8 (
9
" 2+ 8 % P ( ' (
K 2+ 8(( 8( 9 ' ( ( 8(( . 8 '
8 '8 ( ( 8
$2 K 2+ 28 8 ' ( P 8 8 8 +
$ 1! " + 5 5
+ FR . DR
! 2 2+ 5 8 8 8
2 + 8 8 > /( /( . 8 8 8 ' 8P
< 8 8 8 > 9 %( ( 8 89 8
8 8 ' = 9 ( ( 8 8 8 8 (8 ' 8
' 8 ' ( 8 (8 2 ' % ( ' ' (8 / P ( 8 8
" 9 ' 8 '8 ( 8
" 2+ 8 ' 8 ( 8 ( ( 8 9 8 8 8 8 (
8 8 8 8 ' =
K 2+ (8 9 %( 8 8 ( (( 8 ( 8
' P8
$2 K 2+ ( ( 9 * . 9 ( 8 ' ( 8 * ( <8
$ 1! " + " 1
+ FR . DR
! 2 2+ 5 8 8 8 . '
2 + 2 8> 9 ( 8P8 9 (
' A ((8 B 8P8 ' = 8 ' 8P ' ( 8
8 8%P 8 8 ( 8 ' 8> = 8 ' (
8P8
" 2+ 8 ' ( 8 / P 8
K 2+ ' 8 L (8 8 > 9 = (
8 /8( ( 8 ( '8 8 8 8%P 8 * (
( 8 8 P 8
$2 K 2+ 4 ( ( 9 ' 8 8 9
% ( 8 '(
$ 1! " + d S S 2!2 4 1 2 K $!2 2 2
+ CR FR . DR
! 2 2+ 5 8 8 8 . =
2 + 2 9 8> 9 d . . ' ( (
A ' 8P B 8 A' P 8 B d . ' ( 8 8
8%P 8 8 ( . 8 ( ( * P8 ' ( 9 . ' ( (
( 8 8 ' < (8 >
" 2+ 2 8> ' d . ' ( * P8 . 8 (
' ( 8( 8 % ( ' ( '8.8 ( 8 '8
K + = 9 ' ( 8 ( = P 8 ' (
(
$ 1! " + 2 5 5 ;! 5 2
+ FR . DR
! 2 2+ 5 8 8 8 = . (8 8 (8
2 + 2 8 ( '8 A . $B L (8 8 > . '8(
8( 8 ( 9 @ 9 '8 ' ( 8( . 9 @ 9 '8 ' ( 8(
58 ( 8( % 8 ' ' 2 8 8 9 '8 ' ( 8(
( 8 ( . ' ( 8 ( 8 '8 2 '8 (8 8 (8
/ 8 8 . P 8 8 8 > 9 ' ( (
8 ( 8 ' ( 8 8 8 8 (( ( 2 5 . 8 ' ( =
8 ' ( = 8 ' 8 ( P ( ( 8 8 '8( 8 ' < (8 >
%( 8 /( $ 2 5 ( P 8 . ' ( (8 8 (8
8 8 8 * 8 ' ( = 8 2 % 8 ' ' . ( 8 =
P 8
" 2+ 8 8 ( ( ( 8 ( ( 8 / P 8
K 2+ 5 % ( ( % ( ( 8 8 ' < (8 >
' ( = 8
$2 K 2+ ( '8 P 8 8 L (8
8 >
$ 1! " + # 2 S 1 2
+ FR . DR
! 2 2+ 5 8 8 8 . 8 8 8 % 8
2 + 8 8 > ' = %( '8( =8
( . (8> = % ( 9 8> 9 8P
% A 8' B 8 ( = 8( . ' ( 8 8 8
A 8 P8 B 8 8%P 8 = ( % 2 % 8 ' 8>
8 ( 8 P8 ( 8 '8( 8 9 % ( ( 8 /
= 8 % ( ( %8 8 '8( 8 9 9 9 8 8P (
8 = 8( 8 8 > = 8 A 8 P8 ( 8 B '8 ( 8 (
P ( 8 ( ' ( % 8 ' '8( '(8M .
8 ( ( = 8( " P 8 9 L 8 8> 9 * .
8 8 ( '8 % 8 8 8 8 8 P8
( 8
" 2+ 8 8 8 ( 8 % 8 = ( 8 8
8 9 ( % = 8(
K 2+ ! = 8 8 P 8 ' ( = ( 8 8 % 8
$2 K 2+ P 8 ( 9 ( M' 8 .
8 8 8 '(8% 9 8 8 8 8 > 8 *
$ 1! " + "! ! "
+ CR FR . DR
! 2 2+ 5 8 8 8
2 + 8 8 > '8 %( '8( ' 8 . (( (
' = 8 ( ( (8>
( 8 "! 8 8 > % ' ( ( 8 ( ' 9
' T ( 8 ! " % ( . ( 8 % % (
8( < 8 8 > 9 * 8 / 8 P (
( . P 8 * 9 8 8 P 8 A 8B
* . ' 8
" 2+ 8 % ' P ( 8 8 ' < (8 >
K 2+ 2 ' = ( 8 8 ( 8 8 >
9 8 /
$2 K 2+
$ 1! " + !" K
+ CR FR . DR
! 2 2+ 5 8 8 =8 ' ( '(
2 + 8 8 > ( ' '8( ( 8 . ( + $
8 P 8 (( ( 8 8 ( 8 8 >
8 5 8 '8 (8> ( ( 8 '8 +
8> 9 '8 8 ' < (8 > . * . T 8 8 (8
8 8 ' ( 8 8%P 8 8 ( / 8 * 9 8
8 8 * 9 ' 8 8 8 (8> /
8 8 P 8 ' ( 8 = ( '8 ( 8( 8 8 ( (
" 2+ 8 ' '( ( 8 ' ( ( 9 8 ' < (8>
* .
K 2+ 2 '8 ( ( 8 %( . % ( ( ( 9 * .
$2 K 2+ % 8 ( ( *8( ( =8 P 8
L (8 8 > 8 / ( *89 8
$ 1! " + 5 ;! K 5 2 ;!
+ CR FR . DR
! 2 2+ 5 8 8 8
2 + 2 ( ' 8 8 > . 8 8 /( /(
< (8> 8 8 > ( ' ( 8 ' ' ( P
( 8 ( ( ' 8 ! < (8> / P 8
' ( ( . ( 8 = ( '8 ( 8(
" 2+ 8 ' ( 8 8 ' ( 8 8 8 / 8 M ' 8
'
K 2+ 5 % ( 8 ( ' 8 L 8
$2 K 2+ 8 8 > ( ( 8 9
$ 1! " + 2 2
+ CR FR . DR
! 2 2+ 5 8 8 8
2 + 2 P 8 8 8 8 8 8 > 8(( 8
'8( =8 ( < (8> 8 8 >
( (( ( 8 8%P 8 8 ( ' 8 ' < (8 >
9 8 . 5 8 8 M ( 8 ( <
(8> 9 / 8 8 P 8 '8( 8 9 8 8 8 (
(( ( 8 / ( %( ' ( ( ( P 8 8
< (8>
" 2+ 8%P 8 P 8 8 ( 8 8 ' (
K 2+ 5 = ( 8 8 ( '8 % ( 8
8 8 . 9 * 8 (
$2 K 2+ 8 ( =8 / ' ( L (8
8 > 9 8 8 / ( '8 % 9
' 8 ( 8 P 8 8
$ 1! " + ;! 4 4 2 4 1 2
+ CR . FR
! 2 2+ 5 8 8 8
2 + 8( 8 8 ( '8 8 8 / '( (8 /
* P / 8 ( 8 ( 8 8 8%( (( (
A ( * ( QB 8 8 8 %(8 ( '8 % 8' (
M 8 8 8 , ( 0 * 9 ' 8 '8 .
% 8 (8> 8 / = ( ' ' (
8 8 ( , ( 0 8 8 9 ( 8 = P 8
* 9 8 8 * . 8 % = /
" 2+ 8 8 8 8 8 ' (8 8
K 2+ ' 8 L (8 8 > 9 = (
8 /8( ( 8 ( '8 8 8 8%P 8 * (
( 8 8 P 8
$2 K 2+
$ 1! " +
+ CR FR . DR
! 2 2+ 5 8 8 8 . =
2 + 2 ( ( 8 = 9 ( '( 8 =8
( / 8 8 ' ( 8( > 2 8( 8 8 '( (8 ' ( 8( >
9 P 8 8 8 8 ' ( 8 * 9
' ( ( (8 . ' ( ( ( P 8 8 (
8 /8( 8 58( 8 '(8 8
< 8 ' (
" 2+ 5 ( ' ( ( ' % 9 8 ' 28 8
' ( 8 M ( 8 8 8 8 ' ( 8 2 ' ' ( '8( % P8
' ' ( ( 8 %(8 ' ( ( *
K 2+ 5 ( ' ( ( 8 ' % 9 8 '
$2 K 2+ 5 ( 9 P 8 8 * M ( 8
8 ( ' 8 9 ' ( ' ( ( 8
( /
$ 1! " + 5 !
+ CR FR . DR
! 2 2+ 5 8 8 8
2 + 2 =8 ' ( P 8 ' 8 L (8
8 > . 8( 9 ' ( 8 ' ( 8 ( 8 (
8 9 8 8 8 8 %( =8 ( = . 8 ' ( % (
9 8 8 = (8 8 '8 ( 8 ( P ( * 9
8 ' < (8> %( ' 8 '8( % P8 ' ( ( P 8
8 8 8 8 8 ' < (8 > @ ( = 8 % 8 '
'8 '( / P 8
" 2+ 8 ' ( =8 '( / P 8 ' ' = (
= * . 8 ' ( 8
K 2+ P 8 8/( '8 % % ( '8 9 8
%( =8 ( = '8( '8 % 9 ( '8(
$2 K 2+
$ 1! " +
+ CR . FR
! 2 2+ 5 8 8 8
2 + 8 8 8 8 > %( '8( ' 8 (8 9
8(( '8 =8 ( + ( % ( 8 ' . (( 2 8 %(
=8 . % ( 8 '8 % 8= , ( 8 80
% ( ( (8 ' . 8 ((
" 2+ 8 ' ' P ( 8 8 ' < (8 >
K 2+ = ( % ( 8 ' . (( ' % ( '8(
9 ( 8 ( '8 % 9 8
$2 K 2+ 8 ( =8 / ' ( L (8
8 > 9 8 8 / ( '8 %
$ 1! " + N 7 2 5 5 O
+ CR . FR
! 2 2+ 5 8 8 8
2 + 2 ( 8 8 > 9 ( '( ' '( .
%( P ( 8 8 8 8(( %( '8( ' 8
'( ' > '( ( ( ( A 8 ' < (8 > ' 8 '8(
%( P B %( =8
" 2+ 5 ( ( 8 * . 9 ( = ( % %( =8
8 8 8 ( /8( + ' ( '8( % P8 ' ( *8 8 8 Q
$2 K 2+ ( =8 ' 8 L (8
8 >
$ 1! " + 5 1 2 2 2
+ CR
! 2 2+ 5 8 8 8 . (P
2 + 8> 8 %( ' ( 8 P 9
'( * ( ' ( 8 (8> ' ( 8 '8( 8 '
9 8 ( ( ' ( P 2 '( . 8 ( 8
. '( ( 8 8 %( (
" 2+ 8 , * ( 0 ' ( 8 P * . 9 % ( 8
K 2+ = ' ( 8 P ' ( 8 ( 8
$2 K 2+
$ 1! " +
+ CR FR . DR
! 2 2+ 5 8 8 8 . 8 8 8 ( 9 * . 8
'8 % % (
2 + 2 9 ( 8 8 > 9 % ( ( ' ( ( 8
8 ' < (8 > 5 ( 9 8 8P % % ( % 8 2
' 8 ( % @ 8( 8
" 2+ 8 8 ' 8
K 2+ 8 * .
$2 K 2+ 4 . 9 ( *8 8 8 % % 8
. 9 ' * % ( L
$ 1! " + 5 2 S $! 2
+ CR FR . DR
! 2 2+ 5 8 8 8 . % 8
2 + ! 8> ( % ( . ( 8 8 ' ( 8 8 8
' ( 8 % ( % ( % 8 8 % ( 8 A% 8 B
< % ( % ( 8 ( 8 8 '8( % ( 2 8 % (
8 ( % (
" 2+ 8 8 8 8
K 2+ = ' ( . % (8 ' % ( '8( 9 ( 8 (
'8 % 9 8 ' ( '8 P 8
$ 1! " + ! !2
+ FR . DR
! 2 2+ 5 8 8 8 . 8 8 ' 8
2 + 4 8 ( 8 8 8 ! 8>
9 2 ' ' 8 ( 8 8 ' < (8 > ( 8 >
(8 ( 8 8 ( ' 8 9 % @ ' ' ( ' (
8 ' < (8 > . * ( 9 ' 8 9
8 8 (8
" 2+ > 8> 9 * . 8 8 ' 8 ( > 9 8 89 ( 8
K 2+ (8 ( ' 8
$2 K 2+
$ 1! " + K 2 5
+ FR . DR
! 2 2+ 5 8 8 8 . * 9
2 + 8 ( '8 4 8 (( ( ( 8 .
8 8 ( 8 8 * 9 9 8 9 8 8 ( 8
' (/ ( 8(( (
" 2+ * 9 9 ( 8(( 8 8
K 2+ 8 8 ( 8 ' (+ % 8 8 8 Q
$2 K 2+ 8 9 ( * 9 ' ( 8 (8 ' (
(8' (
$ 1! " + 2 !
+ CR FR . DR
! 2 2+ 5 8 8 8 . (
2 + ! 8> 9 8( 8 ( = 8
( < % ( ' ( 8 8 ( 8 (8 8 ' < (8> T
(8 (
" 2+ 9 ( , (80 ( ' ( 8 ( ' 8
K 2+ 9 ( 8 8 ' < (8 . M 8 (
$2 K 2+ 4 . 9 ( ' 8 / (8
$ 1! " + Z$ S2
+ FR . DR
! 2 2+ 5 8 8 8 . (8
2 + 1 8 8 8 = ! 8> 9 8 (8
8 . % ( ( L 8 ' < (8 (8 9 '
9 (
" 2+ 2 > 9 9 8 8 (8 % ' ( ( 9
(8
K 2+ 58 8 ( L (8 ' 8(
$2 K 2+ 8 8 (8 M' ( (8
P 8
$ 1! " + ;! 5 "
+ FR . DR
! 2 2+ 5 8 8 8 . (
2 + ! 8> 9 8 8 8 ( 8
8 ( 8 ( 8 ( 8 8 ( 8 ( (
8 8 8 ' ( ' 8 9 ' 8 8 (
8
" 2+ 4 . 9 ( 8 8 8 ' (8 ( 8 ( ' ( 9 8
' 8
K 2+ ( 8 8
$2 K 2+
$ 1! " + N;!3 4 2 2 Y # O
+ FR . DR
! 2 2+ 5 8 8 8
2 + ! 8> 9 =8((8 < 8 8 * 8
'( T ( L (8 9 ( 8 8 ' < (8 > 9 % 8 (
" 2+ 4 9 =8((8 8 L (8 8 ' ( 8(( 8
K 2+ K ( ( /8( ' = (
D !2 7
( 8 M'8 8 ( P 8 ( 8 (8 9 '8 8
= ( 8 . = < ( 8 8 >
' ( 9 8 ' ( = ( '8 8 8 . 9
' ( 8 > '( 8( 8 8 8 8 8 ' 8
( ' ( '8 %( 2 % ( ( ( P 9
P 8 ' = '8Q ( 8 . ' (8
J 2 $ $ " : 2
$ 8( 1 . $ 8( 1 ACGGGB 3 " ' $ ( 8
$ (8 4 @ ACGGDB 0 B # - 8 %(8
$ 8 (
( 8 FI>FEEW J .8 '8( 9 % (( 8
5( (
8 8 ( ACGGCB 8 8 < =
"(
" ( " ( ACGHHB $ 8 8 @(
" ( ACGGFB 7C7 " 0 "( 8 $ ( 8
= K ACGGJB 0 # , #
-%(
( ( ACGHWB $ # , * ' 5 8 ( %8
$ ( 8
. ( F>FEEI D .8
2 * = $ < 8 ACGHJB $ ' ( .
'8( ". 8 (
2 * = ( =8 2 ACGGXB 1 * #
2 @M 8
K =9 = ACGGXB # # ,
-' <8 (