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1: Mucientes A, Fernández-Gutiérrez B, Herranz E, Rodriguez-Rodriguez L, Varadé J, Urcelay E, Lamas JR. Functional implications of single nucleotide polymorphisms rs662 and rs854860 on the antioxidative activity of paraoxonase1 (PON1) in patients with rheumatoid arthritis. Clin Rheumatol. 2018 Dec 26. doi: 10.1007/s10067-018-4394-6. [Epub ahead of print] PubMed PMID: 30588556.

2: Márquez A, Kerick M, Zhernakova A, Gutierrez-Achury J, Chen WM, Onengut-Gumuscu S, González-Álvaro I, Rodriguez-Rodriguez L, Rios-Fernández R, González-Gay MA; Coeliac Disease Immunochip Consortium; Rheumatoid Arthritis Consortium International for Immunochip (RACI); International Scleroderma Group; Type 1 Diabetes Genetics Consortium, Mayes MD, Raychaudhuri S, Rich SS, Wijmenga C, Martín J. Meta-analysis of Immunochip data of four autoimmune diseases reveals novel single-disease and cross-phenotype associations. Genome Med. 2018 Dec 20;10(1):97. doi: 10.1186/s13073-018-0604-8. PubMed PMID: 30572963.

3: King JR, Varadé J, Hammarström L. Fucosyltransferase Gene Polymorphisms and Lewisb- Negative Status Are Frequent in Swedish Newborns, With Implications for Infectious Disease Susceptibility and Personalized Medicine. J Pediatric Infect Dis Soc. 2018 Dec 9. doi:

10.1093/jpids/piy085. [Epub ahead of print] PubMed PMID: 30544260.

4: Varade J, Wang N, Lim CK, Zhang T, Zhang Y, Liu X, Piehl F, Matell R, Cao H, Xu X, Hammarström L. Novel genetic loci associated HLA-B*08:01 positive myasthenia gravis. J Autoimmun. 2018 Mar;88:43-49. doi: 10.1016/j.jaut.2017.10.002. Epub 2017 Oct 14. PubMed PMID: 29037440.

5: Varadé J, García-Montojo M, de la Hera B, Camacho I, García-Martínez MÁ, Arroyo R, Álvarez- Lafuente R, Urcelay E. Multiple sclerosis retrovirus-like envelope gene: Role of the chromosome 20 insertion. BBA Clin. 2015 Feb 19;3:162-7. doi: 10.1016/j.bbacli.2015.02.002. eCollection 2015 Jun. PubMed PMID: 26675450; PubMed Central PMCID: PMC4669942.

6: Matesanz F, Potenciano V, Fedetz M, Ramos-Mozo P, Abad-Grau Mdel M, Karaky M, Barrionuevo C, Izquierdo G, Ruiz-Peña JL, García-Sánchez MI, Lucas M, Fernández Ó, Leyva L, Otaegui D, Muñoz-Culla M, Olascoaga J, Vandenbroeck K, Alloza I, Astobiza I, Antigüedad A, Villar LM, Álvarez-Cermeño JC, Malhotra S, Comabella M, Montalban X, Saiz A, Blanco Y, Arroyo R, Varadé J, Urcelay E, Alcina A. A functional variant that affects exon-skipping and protein expression of SP140 as genetic mechanism predisposing to multiple sclerosis. Hum Mol Genet.

2015 Oct 1;24(19):5619-27. doi: 10.1093/hmg/ddv256. Epub 2015 Jul 7. PubMed PMID:

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7: Delgado-García M, Matesanz F, Alcina A, Fedetz M, García-Sánchez MI, Ruiz-Peña JL, Fernández Ó, Pinto Medel MJ, Leyva L, Arnal C, Delgado C, López Guerrero JA, González-Pérez A, Sáez ME, Villar LM, Álvarez-Cermeño JC, Picón C, Arroyo R, Varadé J, Urcelay E, Izquierdo G, Lucas M. A new risk variant for multiple sclerosis at the immunoglobulin heavy chain locus associates with intrathecal IgG, IgM index and oligoclonal bands. Mult Scler. 2015 Aug;21(9):1104-11. doi: 10.1177/1352458514556302. Epub 2014 Nov 12. PubMed PMID:

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8: de la Hera B, Varadé J, García-Montojo M, Alcina A, Fedetz M, Alloza I, Astobiza I, Leyva L, Fernández O, Izquierdo G, Antigüedad A, Arroyo R, Álvarez-Lafuente R, Vandenbroeck K, Matesanz F, Urcelay E. Human endogenous retrovirus HERV-Fc1 association with multiple sclerosis susceptibility: a meta-analysis. PLoS One. 2014 Mar 3;9(3):e90182. doi:

10.1371/journal.pone.0090182. eCollection 2014. PubMed PMID: 24594754; PubMed Central PMCID: PMC3971560.

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9: García-Montojo M, de la Hera B, Varadé J, de la Encarnación A, Camacho I, Domínguez-Mozo M, Árias-Leal A, García-Martínez A, Casanova I, Izquierdo G, Lucas M, Fedetz M, Alcina A, Arroyo R, Matesanz F, Urcelay E, Alvarez-Lafuente R. HERV-W polymorphism in chromosome X is associated with multiple sclerosis risk and with differential expression of MSRV. Retrovirology.

2014 Jan 9;11:2. doi: 10.1186/1742-4690-11-2. PubMed PMID: 24405691; PubMed Central PMCID: PMC3892049.

10: Garcia-Montojo M, Varade J, Villafuertes E, de La Hera B, Hoyas-Fernandez J, Domínguez- Mozo MI, Rodriguez-Rodriguez L, Tornero-Esteban P, Arias-Leal A, León L, Lamas JR, Alvarez- Lafuente R, Urcelay E, Fernandez-Gutierrez B. Expression of human endogenous retrovirus HERV-K18 is associated with clinical severity in osteoarthritis patients. Scand J Rheumatol.

2013;42(6):498-504. doi: 10.3109/03009742.2013.779021. Epub 2013 May 11. PubMed PMID:

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11: López-Gómez C, Pino-Ángeles A, Órpez-Zafra T, Pinto-Medel MJ, Oliver-Martos B, Ortega- Pinazo J, Arnáiz C, Guijarro-Castro C, Varadé J, Álvarez-Lafuente R, Urcelay E, Sánchez-Jiménez F, Fernández Ó, Leyva L. Candidate gene study of TRAIL and TRAIL receptors: association with response to interferon beta therapy in multiple sclerosis patients. PLoS One. 2013 Apr 29;8(4):e62540. doi: 10.1371/journal.pone.0062540. Print 2013. PubMed PMID: 23658636;

PubMed Central PMCID: PMC3639207.

12: de la Hera B, Varadé J, García-Montojo M, Lamas JR, de la Encarnación A, Arroyo R, Fernández-Gutiérrez B, Alvarez-Lafuente R, Urcelay E. Role of the human endogenous retrovirus HERV-K18 in autoimmune disease susceptibility: study in the Spanish population and meta- analysis. PLoS One. 2013 Apr 25;8(4):e62090. doi: 10.1371/journal.pone.0062090. Print 2013.

PubMed PMID: 23634223; PubMed Central PMCID: PMC3636236.

13: Lamas JR, Rodríguez-Rodríguez L, Tornero-Esteban P, Villafuertes E, Hoyas J, Abasolo L, Varadé J, Alvarez-Lafuente R, Urcelay E, Fernández-Gutiérrez B. Alternative splicing and proteolytic rupture contribute to the generation of soluble IL-6 receptors (sIL-6R) in rheumatoid arthritis. Cytokine. 2013 Mar;61(3):720-3. doi: 10.1016/j.cyto.2012.12.025. Epub 2013 Jan 29.

PubMed PMID: 23375120.

14: Alcina A, Fedetz M, Fernández O, Saiz A, Izquierdo G, Lucas M, Leyva L, García-León JA, Abad- Grau Mdel M, Alloza I, Antigüedad A, Garcia-Barcina MJ, Vandenbroeck K, Varadé J, de la Hera B, Arroyo R, Comabella M, Montalban X, Petit-Marty N, Navarro A, Otaegui D, Olascoaga J, Blanco Y, Urcelay E, Matesanz F. Identification of a functional variant in the KIF5A-CYP27B1- METTL1-FAM119B locus associated with multiple sclerosis. J Med Genet. 2013 Jan;50(1):25-33.

doi: 10.1136/jmedgenet-2012-101085. Epub 2012 Nov 17. PubMed PMID: 23160276; PubMed Central PMCID: PMC3538279.

15: Varadé J, Comabella M, Ortiz MA, Arroyo R, Fernández O, Pinto-Medel MJ, Fedetz M, Izquierdo G, Lucas M, Gómez CL, Rabasa AC, Alcina A, Matesanz F, Alloza I, Antigüedad A, García- Barcina M, Otaegui D, Olascoaga J, Saiz A, Blanco Y, Montalbán X, Vandenbroeck K, Urcelay E.

Replication study of 10 genes showing evidence for association with multiple sclerosis:

validation of TMEM39A, IL12B and CBLB [correction of CLBL] genes. Mult Scler. 2012 Jul;18(7):959-65. doi: 10.1177/1352458511432741. Epub 2011 Dec 22. PubMed PMID:

22194214.

16: Alloza I, Otaegui D, de Lapuente AL, Antigüedad A, Varadé J, Núñez C, Arroyo R, Urcelay E, Fernandez O, Leyva L, Fedetz M, Izquierdo G, Lucas M, Oliver-Martos B, Alcina A, Saiz A, Blanco

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Y, Comabella M, Montalban X, Olascoaga J, Matesanz F, Vandenbroeck K. ANKRD55 and DHCR7 are novel multiple sclerosis risk loci. Genes Immun. 2012 Apr;13(3):253-7. doi:

10.1038/gene.2011.81. Epub 2011 Dec 1. PubMed PMID: 22130326.

17: Trynka G, Hunt KA, Bockett NA, Romanos J, Mistry V, Szperl A, Bakker SF, Bardella MT, Bhaw- Rosun L, Castillejo G, de la Concha EG, de Almeida RC, Dias KR, van Diemen CC, Dubois PC, Duerr RH, Edkins S, Franke L, Fransen K, Gutierrez J, Heap GA, Hrdlickova B, Hunt S, Plaza Izurieta L, Izzo V, Joosten LA, Langford C, Mazzilli MC, Mein CA, Midah V, Mitrovic M, Mora B, Morelli M, Nutland S, Núñez C, Onengut-Gumuscu S, Pearce K, Platteel M, Polanco I, Potter S, Ribes- Koninckx C, Ricaño-Ponce I, Rich SS, Rybak A, Santiago JL, Senapati S, Sood A, Szajewska H, Troncone R, Varadé J, Wallace C, Wolters VM, Zhernakova A; Spanish Consortium on the Genetics of Coeliac Disease (CEGEC); PreventCD Study Group; Wellcome Trust Case Control Consortium (WTCCC), Thelma BK, Cukrowska B, Urcelay E, Bilbao JR, Mearin ML, Barisani D, Barrett JC, Plagnol V, Deloukas P, Wijmenga C, van Heel DA. Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease. Nat Genet. 2011 Nov 6;43(12):1193-201. doi: 10.1038/ng.998. PubMed PMID: 22057235; PubMed Central PMCID: PMC3242065.

18: Rodríguez-Rodríguez L, Lamas JR, Varadé J, Tornero-Esteban P, Abasolo L, de la Concha EG, Jover JA, Urcelay E, Fernández-Gutiérrez B. Combined influence of genetic and environmental factors in age of rheumatoid arthritis onset. Rheumatol Int. 2012 Oct;32(10):3097-102. Epub 2011 Sep 16. PubMed PMID: 21922340.

19: López-Gómez C, Fernández O, García-León JA, Pinto-Medel MJ, Oliver-Martos B, Ortega- Pinazo J, Suardíaz M, García-Trujillo L, Guijarro-Castro C, Benito-León J, Prat I, Varadé J, Álvarez- Lafuente R, Urcelay E, Leyva L. TRAIL/TRAIL receptor system and susceptibility to multiple sclerosis. PLoS One. 2011;6(7):e21766. doi: 10.1371/journal.pone.0021766. Epub 2011 Jul 21.

PubMed PMID: 21814551; PubMed Central PMCID: PMC3140982.

20: Varadé J, Palomino-Morales R, Ortego-Centeno N, Díaz-Rubio M, Fernández-Gutiérrez B, González-Gay MÁ, Pascual-Salcedo D, Balsa A, Iglesias A, Gómez-García M, Witte T, Radstake TR, Coenen MJ, Urcelay E, Martín J. Analysis of the REL polymorphism rs13031237 in autoimmune diseases. Ann Rheum Dis. 2011 Apr;70(4):711-2. doi: 10.1136/ard.2010.134593. Epub 2010 Sep 27. PubMed PMID: 20876593.

21: Rodríguez-Rodríguez L, Lamas JR, Varadé J, López-Romero P, Tornero-Esteban P, Abasolo L, de la Concha EG, Jover JA, Urcelay E, Fernández-Gutiérrez B. Plasma soluble IL-6 receptor concentration in rheumatoid arthritis: associations with the rs8192284 IL6R polymorphism and with disease activity. Rheumatol Int. 2011 Mar;31(3):409-13. doi: 10.1007/s00296-010-1593-0.

Epub 2010 Jul 27. PubMed PMID: 20661738.

22: Lamas JR, Rodríguez-Rodríguez L, Varadé J, López-Romero P, Tornero-Esteban P, Abasolo L, Urcelay E, Fernández-Gutiérrez B. Influence of IL6R rs8192284 polymorphism status in disease activity in rheumatoid arthritis. J Rheumatol. 2010 Aug 1;37(8):1579-81. doi:

10.3899/jrheum.091455. Epub 2010 Jun 15. PubMed PMID: 20551110.

23: Varadé J, Lamas JR, Fernández-Arquero M, Jover JA, de la Concha EG, Martínez A, Fernández- Gutierrez B, Urcelay E. NO role of NOS2A susceptibility polymorphisms in rheumatoid arthritis.

Nitric Oxide. 2009 Nov-Dec;21(3-4):171-4. doi: 10.1016/j.niox.2009.07.005. Epub 2009 Jul 25.

PubMed PMID: 19635578.

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24: Varade J, Ramón Lamas J, Rodríguez L, Fernández-Arquero M, Loza-Santamaría E, Jover JA, de la Concha EG, Fernández-Gutierrez B, Urcelay E, Martínez A. IL23R and IL12B genes:

susceptibility analysis in rheumatoid arthritis. Ann Rheum Dis. 2009 Jul;68(7):1230-2. doi:

10.1136/ard.2008.099275. PubMed PMID: 19525409.

25: Varadé J, Loza-Santamaría E, Fernández-Arquero M, Lamas JR, de Los Angeles Figueredo M, Jover JA, de la Concha EG, Rodríguez L, Urcelay E, Fernández-Gutiérrez B, Martínez-Doncel A.

Shared epitope and anti-cyclic citrullinated peptide antibodies: relationship with age at onset and duration of disease in rheumatoid arthritis. J Rheumatol. 2009 May;36(5):1085-6. doi:

10.3899/jrheum.080735. PubMed PMID: 19435975.

26: Márquez A, Varadé J, Robledo G, Martínez A, Mendoza JL, Taxonera C, Fernández-Arquero M, Díaz-Rubio M, Gómez-García M, López-Nevot MA, de la Concha EG, Martín J, Urcelay E.

Specific association of a CLEC16A/KIAA0350 polymorphism with NOD2/CARD15(-) Crohn's disease patients. Eur J Hum Genet. 2009 Oct;17(10):1304-8. doi: 10.1038/ejhg.2009.50. Epub 2009 Apr 1. PubMed PMID: 19337309; PubMed Central PMCID: PMC2986636.

27: Martínez A, Perdigones N, Cénit MC, Espino L, Varadé J, Lamas JR, Santiago JL, Fernández- Arquero M, de la Calle H, Arroyo R, de la Concha EG, Fernández-Gutiérrez B, Urcelay E.

Chromosomal region 16p13: further evidence of increased predisposition to immune diseases.

Ann Rheum Dis. 2010 Jan;69(1):309-11. doi: 10.1136/ard.2008.098376. Erratum in: Ann Rheum Dis. 2011 Jan;70(1):240. PubMed PMID: 19221398.

28: Martínez A, Varadé J, Márquez A, Cénit MC, Espino L, Perdigones N, Santiago JL, Fernández- Arquero M, de la Calle H, Arroyo R, Mendoza JL, Fernández-Gutiérrez B, de la Concha EG, Urcelay E. Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases. Arthritis Rheum. 2008 Sep;58(9):2598-602. doi: 10.1002/art.23792. PubMed PMID:

18759272.

29: Martínez A, Varadé J, Lamas JR, Fernández-Arquero M, Jover JA, de la Concha EG, Fernández- Gutiérrez B, Urcelay E. GDF5 Polymorphism associated with osteoarthritis: risk for rheumatoid arthritis. Ann Rheum Dis. 2008 Sep;67(9):1352-3. doi: 10.1136/ard.2007.085050. Erratum in:

Ann Rheum Dis. 2009 Jun;68(6):1080. PubMed PMID: 18697781.

30: Martínez A, Santiago JL, Varadé J, Márquez A, Lamas JR, Mendoza JL, de la Calle H, Díaz- Rubio M, de la Concha EG, Fernández-Gutiérrez B, Urcelay E. Polymorphisms in the selenoprotein S gene: lack of association with autoimmune inflammatory diseases. BMC Genomics. 2008 Jul 14;9:329. doi: 10.1186/1471-2164-9-329. PubMed PMID: 18625033;

PubMed Central PMCID: PMC2491642.

31: Martínez A, Varadé J, Lamas JR, Fernández-Arquero M, Jover JA, de la Concha EG, Fernández- Gutiérrez B, Urcelay E. Association of the IFIH1-GCA-KCNH7 chromosomal region with rheumatoid arthritis. Ann Rheum Dis. 2008 Jan;67(1):137-8. PubMed PMID: 18077546.

32: Nuñez C, Santiago JL, Varadé J, de la Calle H, Figueredo MA, Fernandez-Gutierrez B, de la Concha EG, Urcelay E, Martínez A. IL4 in the 5q31 context: association studies of type 1 diabetes and rheumatoid arthritis in the Spanish population. Immunogenetics. 2008 Jan;60(1):19-23.

Epub 2007 Dec 7. PubMed PMID: 18064451.

33: Martínez A, Orozco G, Varadé J, Sánchez López M, Pascual D, Balsa A, García A, de la Concha EG, Fernández-Gutiérrez B, Martín J, Urcelay E. Macrophage migration inhibitory factor gene:

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influence on rheumatoid arthritis susceptibility. Hum Immunol. 2007 Sep;68(9):744-7. Epub 2007 Jul 27. PubMed PMID: 17869648.

34: Núñez C, Márquez A, Varadé J, Martínez A, Polanco I, Maluenda C, Fernández-Arquero M, de la Concha EG, Urcelay E. No evidence of association of the MYO9B polymorphisms with celiac disease in the Spanish population. Tissue Antigens. 2006 Dec;68(6):489-92. PubMed PMID:

17176439.

35: Martínez A, Sánchez-Lopez M, Varadé J, Mas A, Martín MC, de Las Heras V, Arroyo R, Mendoza JL, Díaz-Rubio M, Fernández-Gutiérrez B, de la Concha EG, Urcelay E. Role of the MHC2TA gene in autoimmune diseases. Ann Rheum Dis. 2007 Mar;66(3):325-9. Epub 2006 Sep 29. PubMed PMID: 17012290; PubMed Central PMCID: PMC1855999.

36: Núñez C, Alecsandru D, Varadé J, Polanco I, Maluenda C, Fernández-Arquero M, de la Concha EG, Urcelay E, Martínez A. Interleukin-10 haplotypes in Celiac Disease in the Spanish population.

BMC Med Genet. 2006 Mar 31;7:32. PubMed PMID: 16579847; PubMed Central PMCID:

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37: Palá-Paúl J, Pérez-Alonso MJ, Velasco-Negueruela A, Varadé J, Villa AM, Sanz J, Brophy JJ.

Analysis of the essential oil composition from the different parts of Eryngiumglaciale Boiss. from Spain. J Chromatogr A. 2005 Nov 11;1094(1-2):179-82. Epub 2005 Sep 30. PubMed PMID:

16202420. 38: Palá-Paúl J, Pérez-Alonsoa MJ, Velasco-Negueruela A, Vadaré J, Villa AM, Sanz J, Brophy JJ. Essential oil composition of the different parts of Eryngium bourgatii Gouan from Spain. J Chromatogr A. 2005 May 13;1074(1-2):235-9. PubMed PMID: 15941061.

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