[PDF] Top 20 A produção sobre a educação da mulher na educação de jovens e adultos

... 3) efficacy data including median progression-free survival (mPFS), median overall survival (mOS), complete response, partial response (PR), stable disease, and objective response rate ... See full document

... demonstrated efficacy on mCRC with microsatellite instability but remain ineffective alone in microsatellite stable ...properties. Durvalumab (D) is a human monoclonal antibody (mAb) that inhibits binding ... See full document

... In this article, we compared the efficacy and safety of apatinib in patients with various types of advanced malignant solid tumors. First, compared with the control group, the apatinib ... See full document

... This phase 1b study investigated the PK, safety, and pre- liminary ef fi cacy of oral FTD/TPI in Chinese patients with solid tumors, mostly CRC. The exposure to FTD increased 2.4-fold with multiple ... See full document

... the efficacy of adali- mumab in patients who have failed to respond to previous bio- logics has been evaluated in a few studies, and reported good clinical response ... See full document

... the efficacy endpoints found significantly prolonged survival for patients in the azacitidine arm compared with the best supportive care or low-dose cytarabine subgroups but not compared with the intensive ... See full document

... similar efficacy to other anti-diabetic drugs, including vildagliptin, nateglinide, and metformin, in terms of reducing HbA 1c and fasting and postprandial glucose ... See full document

... Despite the massive inroads made by modern Western medicine, herbal and natural therapies are experiencing a revival in usage, partly as a result of extensive research in their modes of action and clinical ... See full document

... superior efficacy and comparable safety compared with its monocomponents, open-label TIO, and placebo and may be used as a treatment option for the management of moderate-to-severe COPD in Japanese ... See full document

... day. 22 No studies of genotoxicity or reproductive toxicity have been identi fi ed, but the chemistry of the materials, their recognized safety in food use and lack of toxicity in feeding trials does not suggest ... See full document

... Hepatocellular carcinoma (HCC) is a very highly inva- sive tumor that metastasizes hematogenously and lym- phogenously to distant sites. Most frequently affected sites are the lungs, regional lymph nodes, bones, and ... See full document

... the safety of antipsychotics because adverse effects which occur right in the beginning (eg, akathisia) might be overvalued against long-term effects (eg, metabolic syndrome in several ... See full document

... To date, various endoscopic techniques have been applied to rectal carcinoid tumors. Such techniques include endo- scopic polypectomy, endoscopic mucosal resection (EMR) and endoscopic submucosal dissection ... See full document

... Sarcomas are a heterogeneous group of mesenchymal malignancies. In recent years, studies have demonstrated that inhibition of angiogenic pathways or disruption of established vasculature can attenuate the growth of ... See full document

... studies, efficacy of lenvatinib in solid tumors was demonstrated, and these encouraging results have led to the development of a Phase II study using lenvatinib in advance radioiodine-refractory ... See full document

... Minocycline is not approved by the FDA for the treatment of rosacea, but it is for the treatment of acne. There are currently no clinical trials that have evaluated the use of minocycline for the treatment of rosacea and ... See full document

... metastases and vascular invasion, the early diagnosis rate of ICC remains challenging. Moreover, less than 30% of patients have resectable tumors; 2,8,9 the fi ve-year survival after surgical resection of ICC is ... See full document

... A post hoc analysis of data from a 6-week, randomized, open-label, parallel- group, comparative trial (Statin Therapies for Elevated Lipid Levels compared Across doses to Rosuvastatin [r] ... See full document

... Finally, a Phase Ib study investigated the feasibility of trebananib administration in patients with recurrent ovarian carcinoma in combination with either pegylated doxorubicin or topotecan (NCT00770536). The study has ... See full document

... the efficacy and safety analysis of pembrolizumab in patients with cancers of different histological types, by analyzing the largest sample size we could reach, and thus offered the most robust summary up ... See full document