[PDF] Top 20 Accesibilidad académica: un concepto en construcción
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Gaucher disease: clinical profile and therapeutic developments
... for Gaucher disease, the manufacturer reported spending less than $58M for ...unequivocal therapeutic advantages, companies with an active discovery portfolio can steal an advantage if their drug has ... See full document
63
Impact of imiglucerase supply constraint on the therapeutic management and course of disease in French patients with Gaucher disease type 1
... Gaucher Disease (GD) is an inherited lysosomal storage disease, attributable to glucocerebrosidase enzyme de- ficiency; in rare cases, the absence of saposin C, an ac- tivator of glucocerebrosidase, ... See full document
9
Imiglucerase in the treatment of Gaucher disease: a history and perspective
... of disease is not only informative but also almost invariably ...Although Gaucher disease was until quite recently an arcane specialism within disparate clinical fields including hematology, ... See full document
18
Taliglucerase alfa: safety and efficacy across 6 clinical studies in adults and children with Gaucher disease
... 1 Gaucher disease (GD) in several countries and the first plant cell – expressed recombinant therapeutic protein approved by the US Food and Drug Administration for ... See full document
244
Lysosomal Storage Disorders in the Newborn
... for clinical use is miglustat ...with Gaucher type 1 in Europe, the United States, and Israel. In Gaucher disease, substrate-reduction therapy is recommended only for adults when ERT is not a ... See full document
6
Gaucher disease and the synucleinopathies: refining the relationship
... Gaucher disease (OMIM 230800, 230900, 231000), the most common lysosomal storage disorder, is due to a deficiency in the enzyme ...glucocerebrosidase. Gaucher patients display a wide spectrum of ... See full document
26
Optimal therapy in Gaucher disease
... of different pathological pathways. Thus the optimal therapeutic expectations may differ in each patient with GD. Despite better tissue penetration and alternative mechanisms of action of novel therapeutics what ... See full document
8
Rethinking fatigue in Gaucher disease
... relevant disease signs and symptoms [8, 9] and la- boratory parameters is ...patient clinical status and achievement of therapeutic goals ...of disease should be evaluated at regular ... See full document
23
New developments in clinical aspects of lymphatic disease
... Current treatments for lymphedema do not reverse the funda- mental pathophysiology and therefore provide, at best, stabiliza- tion and modest delays in the appearance of end-stage sequelae, such as disfigurement and loss ... See full document
12
Profile of eliglustat tartrate in the management of Gaucher disease
... The advent of the ERT for GD in 1990s changed the natural history of the disease, and this therapeutic approach is still considered as the standard of care for GD. ERT is effective in counteracting the ... See full document
8
Dental profile of patients with Gaucher disease
... a clinical examination for decayed, missing and filled surfaces of teeth ...routine Gaucher-related fol- low-up, including complete blood count and coagulation tests, prothrombin time (PT) and partial ... See full document
8
Development of idursulfase therapy for mucopolysaccharidosis type II (Hunter syndrome): the past, the present and the future
... the disease and, in conjunction with the appropriate supportive care, remains a cornerstone of the management of patients with MPS II ...variable disease presentation and progression and an incomplete ... See full document
15
Hirschsprung’s disease in adults: Clinical and therapeutic features
... Two therapeutic approaches were adopted in the management of our patients: The first approach consisted of a two-stage surgical operation comprising a colostomy in its first phase, for bowel cleaning by removal of ... See full document
5
<p>Therapeutic Effects of Garlic on Hepatic Steatosis in Nonalcoholic Fatty Liver Disease Patients: A Randomized Clinical Trial</p>
... the therapeutic potential of garlic and its derivatives against modi fi able cardiovascular risk factors 14 and ...the therapeutic effect of garlic for hepatic steatosis in NAFLD patients remains ... See full document
15
Clinical profile in chronic obstructive pulmonary disease patients and their evaluation with spirometry and 2d echo
... A clinical diagnosis of COPD should be considered in any patient who has dyspnea, chronic cough or sputum production and/or a history of exposure to risk factors for the ... See full document
8
How do demographic transitions and public health policies affect patients with Parkinson’s disease in Brazil?
... An online search using known search engines and the keywords “Association”, “Associations”, “Philanthropic”, “NGOS”, “Support Center”, “Institute”, “Home”, and “Parkinson’s disease” revealed 30 such associations ... See full document
16
Management of Neutralizing Antibody to Ceredase in a Patient With Type 3 Gaucher Disease
... 3 Gaucher disease became overt in the early part of 1993 when he had a reduction in his hematocrit and platelet levels concomitant with an increase in serum acid ... See full document
103
Clinical Profile of Neurological Manifestations in Wilson Disease
... of disease symptoms as early as 2-3 yr of age, when Wilson disease may not typically be considered in the differential ...liver disease as late as 50 yr of ... See full document
GC MS ANALYSIS OF ALBIZIA LEBBECK BENTH
... chemical profile present in the petroleum ether, metahnolic, ethylacetate extract of leaves of Albizia lebbeck Benth by using GCMS analysis and predict their biological activity using ... See full document
82
Clinical Profile of Parkinson's Disease: Experience of Niger.
... the clinical picture by the realization of paraclinical examinations and to confirm the diagnosis of PD by the good improvement of clinical symptoms by ...the clinical features suggest a secondary ... See full document
13
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