[PDF] Top 20 Álbum de familia (1971) / José Watanabe

... the vacuoles were devoid of immunoreactivity (Figure 2B, inset), while many muscle fibers showed weak sarcolemmal AQP4 immunoreactiv- ity (Figure ...AQP4 expression was occasionally observed (Figure 2D, ... See full document

... autophagic vacuoles and the accumulation of minocycline-induced pigments is ...The rimmed vacuoles were positive for p62/SQSTM1 (p62) immu- nostaining (Figure 4A), which has been reported as a ... See full document

... Inherited distal myopathies more likely to produce this pattern would include hereditary inclusion body myopathy (hIBM), Laing myopathy (MYH7 mutation), and some myofibrillar ...Laing myopathy ... See full document

... Most neuromyelitis optica (NMO) patients have IgG against aquaporin-4 (AQP4), here termed AQP4-IgG [1,2]. AQP4 is a water channel protein found in astro- cytes throughout the central nervous system (CNS), ... See full document

... AQP4 expression has been shown to enhance astrocyte migration in vitro and in vivo ...AQP4 expression is associated with glial scars [33,34], although the associated water content was not directly measured ... See full document

... ing intravenous saline perfusion in human [23] indicating that AQP1 is required for maintaining permeability of pulmonary vasculature. Our findings are consistent with this hypothesis, as asthma also led to decreased ... See full document

... whether the criteria for RRMS were met. As a limitation, it should be stressed that clinical data were sparse in some reports, leaving some doubt regarding the exact clinical course. In one OCB-positive case, the spinal ... See full document

... protein, AQP4 in astrocytes suggests a possible involve- ment in MRI. Diffusion-weighted magnetic resonance imaging (DWI) is widely used as a diagnostic tool in clinical and research settings to assess edematous dam- age ... See full document

... Total 40 mixed gender of 3 weeks old Sprague- Dawley rats were used, weighting approximate- ly 60-80 g. Animals were randomly assigned to one of these four groups (n=10 each): 1) saline control group; 2) untreated group; ... See full document

... were large ranging from 50 to 80 m m. Many of the fibers contained single or multiple unrimmed va- cuoles that appeared empty in the modified Gomori trichrome preparation (figure, B.a). There was no increase in ... See full document

... LABORATORY METHODS AND RESULTS Illumina TruSeq 62 Mb exome capture sequencing (100 bp paired-end reads, HiSeq 2000) and alignment (UCSC hg19) was performed on DNA from III-1 and III-5. No genetic variants known to cause ... See full document

... the expression of AQP4 but downregu- lated the brain water content, suggesting that the alleviation of brain edema was at least in part associated with the high expression of ...the expression level ... See full document

... Whole brain tissues were homogenized and the samples were loaded onto 4% stacking/12% separating SDS- polyacrylamide gels. The proteins were electrophoretically transferred onto nitrocellulose membranes. After the ... See full document

... of distal lower limb muscles showed an excess of low amplitude polyphasic units of brief duration and a full interference pattern (< 1 mV) during a weak ... See full document

... histochemical expression of AQP4 in the SE group showed an upward trend over ...AQP4 expression began to increase at 6 h, and increased significantly from 24 h to 72 ...AQP4 expression increases ... See full document

... puted tomography (CCT) confirmed cerebral atrophy [2]. Subsequently, neurological symptoms such as mental retardation, epileptic seizures, tremor and pyramidal syn- dromes were observed in patients with cystinosis [3,4]. ... See full document

... AQP1 expression was reduced in RCC, 12 and that expression levels of AQP1 pro- vided useful prognostic information for patients with ...that expression of AQP1 by ≥ 50% of tumor cells was associated ... See full document

... were treated with 1% formaldehyde for 30 minutes at room temperature, followed by the addition of glycine to a final concentration of 0.125 M. Cells were washed in 4°C phos- phate-buffered saline and pelleted. ... See full document

... NMO-IgG. Expression of AQP4 on the basolateral cell membranes versus apical cell membrane could also moderate the availability of AQP4 targets for immune system effectors, especially AQP4-spe- cific ... See full document

... Functional insights – Evidence strongly suggests that DNAJB6-myopathy mutations are gain-of-deleterious- function mutations. Protein mutated at Phe89, Phe93 and Pro96, or lacking the G/F domain (ΔG/F), intro- ... See full document