[PDF] Top 20 Ciencia, tecnología e innovación en Colombia: ¿para qué?
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Glycyrrhetinic acid-modified chitosan nanoparticles enhanced the effect of 5-fluorouracil in murine liver cancer model via regulatory T-cells
... Mouse serum specimens were obtained from each group and maintained at − 20 ° C for determination of interleukin-2 (IL-2) and interferon gamma (IFN- γ ). For enzyme-linked immunosorbent assay (ELISA) (Santa Cruz ... See full document
9
Optimized synthesis of glycyrrhetinic acid-modified chitosan 5-fluorouracil nanoparticles and their characteristics
... used chitosan (CTS) and hepatoma cell-specific binding molecule glycyrrhetinic acid to synthesize glycyrrhetinic acid-modified chitosan ...(5-FU) ... See full document
6
Irinotecan and 5-fluorouracil-co-loaded, hyaluronic acid-modified layer-by-layer nanoparticles for targeted gastric carcinoma therapy
... hyaluronic acid (HA)-modified layer-by-layer nanoparticles (NPs) are applied for improving anticancer treatment efficacy and reducing toxicity and side ...and 5-fluorouracil ... See full document
13
Folic acid decorated chitosan nanoparticles and its derivatives for the delivery of drugs and genes to cancer cells
... a murine hepatic cell carcinoma (MH134) 64 ...tumour cells through receptor-mediated endo- ...significantly enhanced compared to both the free drugs and necessarily deters tumour growth than free ... See full document
18
Targeted delivery of doxorubicin-utilizing chitosan nanoparticles surface-functionalized with anti-Her2 trastuzumab
... India). Chitosan, with a medium molecular weight and deacetylation of about 96%, was supplied by Fluka, ...hydrochloric acid, glacial acetic acid, sodium hydroxide, succinic anhydride, ... See full document
16
Inhibition of leukemic cells by valproic acid, an HDAC inhibitor, in xenograft tumors
... the cells were prepared with 1% formaldehyde and kept at room temperature for 10 minutes, small pieces of tumor tissue from each treatment group were resuspended and precipitated using cell lysis ... See full document
7
Detailed characterization of tumor infiltrating lymphocytes in two distinct human solid malignancies show phenotypic similarities
... fraction. Cells were then washed three times in PBS (1 st wash @ 1,000 rpm for 10 minutes to remove debris, then 2x @1,250 for 5 minutes) and ...6 cells/ml in PBS prior to staining or ... See full document
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In vivo biodistribution, anti-inflammatory, and hepatoprotective effects of liver targeting dexamethasone acetate loaded nanostructured lipid carrier system
... anti-inflammatory effect of DXMA-NLCs was investigated on carrageenan-induced ...Figure 5 shows the edema value of DXMA-NLCs and DXMA-sol groups, induced by carrageenan, demonstrating that both DXMA-NLCs ... See full document
9
Investigation of the interaction of the synthesized chitosan 5 fluorouracil with
... Any toxic metal may be called heavy metal, irrespective of their atomic mass or density [15,16]. Heavy metals are a member of an ill-defined subset of elements that exhibit metallic properties. These include the ... See full document
51
Thermosensitive hydrogel based on chitosan and its derivatives containing medicated nanoparticles for transcorneal administration of 5-fluorouracil
... (PB; pH 7.4, 0.13 M) contained in the other hemicell. The initial drug concentration in the PB-containing hemicells was different among the different cells and spanned a range sup- posed to encompass the unknown ... See full document
16
Therapeutic properties of a vector carrying the HSV thymidine kinase and GM CSF genes and delivered as a complex with a cationic copolymer
... We used PEI-containing polyplexes modified with poly- ethylene glycol (PEG) and the cell-penetrating peptide TAT. The properties and behavior of these polyplexes in different cell lines could be adjusted to ... See full document
7
Journal of Applied Pharmaceutical Science
... succinic acid and 1,4-butanediol, while Poly(butylene succinate- co-adipate) (PBSA) is synthesized by polycondensation of succinic and adipic acids with ...dicarboxylic acid and dihydric alcohol used to ... See full document
13
Evaluation of cytotoxic effect of metallic nanoparticles in an in vitro liver cancer model
... untreated cells), were set as 100% viability. Cells subjected to osmotic shock (treated with distilled water) were taken as positive controls (zero viability) were used to subtract background from all OD ... See full document
22
Hypoxia-induced CCL28 promotes recruitment of regulatory T cells and tumor growth in liver cancer
... knockdown cells (Figure ...Treg cells than normoxic ...Treg cells can be effectively blocked by anti-CCL28 antibodies, suggesting CCL28 may enrich the Treg ...tumor model, foxp3 expression was ... See full document
95
Similarity between Some Biological Systems, Organotropism and Metastatic Process: Active Role Played By Secondary Organ?
... tumor cells to organ-speci ic, microvascular ...endothelial cells isolated from large vessels ...endothelial cells (BAEC) on organ-speci ic matrix components, termed tumor attachment modulators ... See full document
9
<p>ROS-Responsive Chitosan Coated Magnetic Iron Oxide Nanoparticles as Potential Vehicles for Targeted Drug Delivery in Cancer Therapy</p>
... gated. 5-FLU is an anti-metabolite of the pyrimidine class, with a broad spectrum of activity and is quite effective in the chemotherapy of solid malignant tumors, such as that of the abdominal cavity, ovary, ... See full document
5
Interaction of cancer cells with magnetic nanoparticles modified by methacrylamido-folic acid
... of nanoparticles modified with folic acid by NIH/3T3 and 5RP7 cancer cells, as well as nanoparticle size and morphology, were determined using a TEM (FEI Tecnai ...sulfoxide. ... See full document
22
IN-VIVO ANTI-TUMOR EFFECT OF 5-FLUOROURACIL LOADED CHITOSAN-SODIUM DEOXYCHOLATE NANOPARTICLES
... and 5-FU loaded CS-DS nanoparticles (F2) respectively. 5-FU was given at a dose 20 mg/kg body weight since the intra-tumor delivery of anticancer was considered a valid therapeutic strategy for ... See full document
176
Andrographolide enhanced 5-fluorouracil-induced antitumor effect in colorectal cancer via inhibition of c-MET pathway
... M 5-Fu, 10 μ M Andro, and combination treatment of 5-Fu with ...The cells were collected and lysed using real-time instant presence with advertisement in 72 ...in 5% milk at room temperature, ... See full document
16
Polymeric Superparamagnetic Nanoparticles for Drug Delivery Applications
... (50,99). Chitosan has repeated hexosaminide residues where each unit is made of two hydroxyl groups and an amino ...group. Chitosan attaches firmly and stably to SPIONs surface due to these groups that form ... See full document
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