[PDF] Top 20 La Ciudad de Dios. Libros VIII-XV (Biblioteca Clásica Gredos) - San Agustín
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Whole genome sequencing reveals potential targets for therapy in patients with refractory KRASmutated metastatic colorectal cancer
... Some notable CNVs were seen in these patients. CLN2 had amplification in the MYC oncogene. A number of known tumor suppressor genes were deleted in CLN2 such as TP53, SMAD2, SMAD3, SMAD4, BCL2 and TCF4. SMAD4 ... See full document
61
Next Generation Sequencing (NGS) in Relapsed/ Refractory HPV Negative Head and Neck Squamous Cell Carcinoma (HNSCC) Reveals Diverse Genomic Alterations and Potential Targets of Therapy
... 3 patients in the present study (1 mutation ...that targets EGFR and was approved for treatment of HNSCC in a phase III ...other cancer types; in phase II trials, lapatinib and gefitinib induced a ... See full document
55
Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesions
... and metastatic CRC, heterogeneity in potentially actionable genes, such as those within the PI3K pathway, is present in at least a subset of ...the potential benefit of aspirin therapy in CRC ... See full document
109
Vorinostat approved in Japan for treatment of cutaneous T-cell lymphomas: status and prospects
... Abstract: Histone acetylation and deacetylation play important roles in the regulation of gene transcription and in the modulation of chromatin structure. The levels of histone acetylation are determined by the ... See full document
28
Factors influencing choice of chemotherapy in metastatic colorectal cancer (mCRC)
... Of Cancer Project (EPOC) study, 272 patients with KRAS wild-type (wt) tumor operable liver metastases were randomized to receive FOLFOX plus or minus cetuximab for 12 weeks before, then 12 weeks following, ... See full document
42
Whole-genome bisulfite sequencing of cell-free DNA identifies signature associated with metastatic breast cancer
... Simon Cancer Center representing 3 cohorts of 40 individuals: cohort 1 is MBC to various organs; cohort 2 is DFS (range: 3–27 years, average 9 years DFS); cohort 3 is H with no history of ... See full document
39
Transcriptomic but not genomic variability confers phenotype of breast cancer stem cells
... Population-based sequencing indicated no clear genetic cause contributing to ...DNA sequencing was performed on non-BCSCs and ...homogenous genome within one sphere. Thus, sequencing of the ... See full document
156
Whole-Genome Sequencing of Human Clinical Klebsiella pneumoniae Isolates Reveals Misidentification and Misunderstandings of Klebsiella pneumoniae, Klebsiella variicola, and Klebsiella quasipneumoniae
... by sequencing the genes in the capsule locus, has been used more recently as a molecular tool to subclassify ...human patients would be misidentified by typing methods such as ...genotyping. ... See full document
10
Role of HER2 mutations in refractory metastatic breast cancers: targeted sequencing results in patients with refractory breast cancer
... breast cancer, especially in patients with HER2 overexpression ...breast cancer patients possess a HER2 mutation ...for patients with refractory HER2 positive BC ... See full document
204
Successful treatment of metastatic colorectal cancer with apatinib: report of two cases and literature review
... had a magnetic resonance (MR) imaging on Mar 21, 2013, due to lumbosacral pain, and it demonstrated abnormal signal intensity in the sacral vertebrae. The diagnosis was stage IV rectal adenocarcinoma with pelvic ... See full document
6
Enhancement of antibody-dependent cell mediated cytotoxicity: a new era in cancer treatment
... Abstract: The therapeutic efficacy of some anti-tumor monoclonal antibodies (mAbs) depends on the capacity of the mAb to recognize the tumor-associated antigen and induce cytotoxic- ity via a network of immune effector ... See full document
5
Genome sequencing and crop improvement
... unassembled genome sequence data and expressed sequence tags ...reference genome sequence, genetic mapping of these markers is required to determine their genomic ...the genome that can analysed ... See full document
18
<p>Selecting treatment options in refractory metastatic colorectal cancer</p>
... 33 patients with KRAS WT mCRC who were refractory to previous fluoropyrimidines, oxaliplatin, irinotecan, cetuximab, and bevacizumab and in whom previous treatment with cetux- imab was effective in any ... See full document
5
Famitinib versus placebo in the treatment of refractory metastatic colorectal cancer: a multicenter, randomized, double-blinded, placebo-controlled, phase II clinical trial
... many patients in the placebo group received fur- ther anti-tumor therapy, especially targeted ...in patients treated with famitinib who had been heavily pre-treated with systematic ...The ... See full document
92
Cancer of the ampulla of Vater: analysis of the whole genome sequence exposes a potential therapeutic vulnerability
... used whole genome sequencing to analyze the genome of a resected ampullary ...ampullary cancer although the 25 to 37% incidence appears to be lower than the approximately 95% rate of ... See full document
5
Ockham’s razor for the MET driven invasive growth linking idiopathic pulmonary fibrosis and cancer
... for cancer can be ...several cancer types and in inducing CSC chemo- and radio-resistance ...efficient cancer spreading as well as stemness ... See full document
7
Screening of potential molecular targets for colorectal cancer therapy
... expression was elevated in human colorectal cancer tissues as a screening source of molecular targets. This starting from human disease samples has a great advantage, because cultured cells and ... See full document
5
Assessment of the cardiac safety between cetuximab and panitumumab as single therapy in Chinese chemotherapy-refractory mCRC
... all patients had normal TNI Ultra ...21 patients from cetux- imab group ...17 patients from panitumumab group ...of patients with TNI Ultra + or TNI Ultra − are summarized in Table ...in ... See full document
5
Targeted or whole genome sequencing of formalin fixed tissue samples: potential applications in cancer genomics
... Performing sequencing analyses using DNA isolated from FFPE samples is technically ...targeted sequencing of single genes [16, 17], as well as the whole exome [18–20] and whole genome ... See full document
94
Whole exome sequencing analysis of urine trans-renal tumour DNA in metastatic colorectal cancer patients
... 24 patients with KRAS or BRAF mutant metastatic colorectal cancer ...urine. Whole exome sequencing (WES) was performed in DNA isolated from tissue, plasma and ...In ... See full document
164
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