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The interplay of reactive oxygen species and the epidermal growth factor receptor in tumor progression and drug resistance
... an additional EGFR T790M mutation represent almost half of all NSCLC TKI-resistant cases [111]. In a basal condi- tion of H1975 NSCLC cells harboring the EGFR T790M mutant, activated EGFR T790M can induce NOX2- mediated ... See full document
8
The new concepts on overcoming drug resistance in lung cancer
... fibroblast growth factor receptor, discoidin domain receptor 2, phosphatidylinositol- 4,5-bisphosphate3-kinase, catalytic subunit alpha (PIK3CA), phosphatase and tensin homologue, Akt, ... See full document
7
Mutations in the phosphatidylinositol 3 kinase pathway: role in tumor progression and therapeutic implications in breast cancer
... promotes resistance to some of the current breast cancer ...human epidermal growth factor receptor (HER)2 and other receptor tyrosine ...cycle progression and survival. In ... See full document
15
Expression of amphiregulin predicts poor outcome in patients with pancreatic ductal adenocarcinoma
... oncogenic factor for more than 20 ...and progression is supported by clinical data showing that AREG can serve as a prognostic and/or a predictive biomarker ...enhanced tumor aggressiveness and ... See full document
48
The epidermal growth factor receptor family in breast cancer
... this receptor in HER-2 mediated ...HER-2 receptor was blocked, suggesting that HER-2/HER-3 dimers are necessary for sustained signaling (Neve et al ...HER-3 receptor, p85-soluble ErbB3 (sErbB3), is a ... See full document
8
The role of reactive oxygen species in tumor cells apoptosis induced by landomycin A
... radicals, respectively. It was revealed that catalase and mannitol effectively inhibited La-mediated tumor cell death, increasing 2.5 times the percentage of alive cells in comparison to La. however, superoxide ... See full document
11
Continuation of epidermal growth factor receptor tyrosine kinase inhibitor treatment prolongs disease control in non- small-cell lung cancers with acquired resistance to EGFR tyrosine kinase inhibitors
... RECIST progression on EGFR TKIs, and 55 patients who satisfied the inclusion criteria were eventually ...The tumor pathology of the patients was all adenocarcinoma, except for two squamous cell ...lung ... See full document
62
Original Article Genetic variations of the TNF-α -308 G>A promoter, and TGF-β1 T869C polymorphisms in Egyptian patients with rheumatoid arthritis
... Abstract: Introduction: Rheumatoid arthritis (RA) is a complex autoimmuno disease. Tumor necrosis factor alpha (TNF-α), and transforming growth factor beta 1 (TGF-β1) are responsible for ... See full document
18
EGFR gene copy number as a predictive biomarker for the treatment of metastatic colorectal cancer with anti-EGFR monoclonal antibodies: a meta-analysis
... inconsistent across different studies. The prevalence of GCN + ranged from 6.9% to 88.9%, and the difference in ORR between patients with GCN + and those with non-increased EGFR GCN (GCN-) varied from − 28% to 84%. ... See full document
13
Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancers
... (cytokines, growth factors, ...its receptor is speci fi c, reversible and involves a large number of low-energy bonds (hydrogen, ionic, hydrophobic, and Van der ... See full document
177
Decorin suppresses tumor cell growth by activating the epidermal growth factor receptor
... for progression through the cell cycle, and can also act as an adaptor protein to assemble and pro- gram kinase complexes for specific functions ...cycle progression is yet another regulatory mecha- nism ... See full document
6
Coffee provides a natural multitarget pharmacopeia against the hallmarks of cancer
... extraction of the compounds present in coffee. These diversified compounds include chemical elements, amino acids, polyphenols, acids, diterpenes, melanoidins, lipids and sugars (Fig. 1) (Pohl et al. 2013; Rodrigues and ... See full document
10
Protein tyrosine phosphatase SHP-1 sensitizes EGFR/HER-2 positive breast cancer cells to trastuzumab through modulating phosphorylation of EGFR and HER-2
... The HER-2 overexpressed human breast cancer SKBr-3 cells were cultured in medium containing 5 μ g/mL trastu- zumab continuously for 6 months, which resulting in the acquisition of trastuzumab resistance. Compared ... See full document
47
<p>The Role of the Reactive Oxygen Species Scavenger Agent, Astaxanthin, in the Protection of Cisplatin-Treated Patients Against Hearing Loss</p>
... These positive effects have been attributed to the ability of astaxanthin to scavenge free radicals, quench singlet oxygen, and inhibit lipid peroxidation. The effect of astaxanthin on protecting cellular ... See full document
5
Prognostic value of <em>EGFR</em> and <em>KRAS</em> in resected non-small cell lung cancer: a systematic review and meta-analysis
... of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with ...mal growth factor receptor gene is not a prognostic factor for ... See full document
48
Conversion of epidermal growth factor receptor 2 and hormone receptor expression in breast cancer metastases to the brain
... This multicenter study was approved by the institutional review board of the coordinating center (Medical Univer- sity of Gdansk, Poland). The archives of neurosurgery and pathology departments were searched to identify ... See full document
10
Gene expression meta-analysis supports existence of molecular apocrine breast cancer with a role for androgen receptor and implies interactions with ErbB family
... contains other EGFR-related genes. We call this cluster the ErbB2 cluster. We also analyzed the clusters that indirectly interact with the AR cluster. Cluster 16 is interesting because although AR is not a member, ... See full document
117
Patient survival and tumor characteristics associated with CHEK2:p I157T – findings from the Breast Cancer Association Consortium
... Association of p.I157T with clinico-pathological markers In our analyses p.I157T was associated with low grade as well as several other markers, which have previously been associated with good prognosis (Table 1). Our ... See full document
15
Tyrosine kinase inhibitors potentiate the cytotoxicity of MDR substrate anticancer agents independent of growth factor receptor status in lung cancer cell lines
... molecularly-targeted drug development is the erbB family of type I receptor tyrosine kinases which consist of EGFR (epidermal growth factor receptor/erbB1/Her-1), HER-2 ... See full document
6
Epidermal growth factor receptor and B7-H3 expression in esophageal squamous tissues correlate to patient prognosis
... Resected tumor tissue specimens were serially sectioned at 3 μ ...stained tumor cells and the intensity of staining; 100 cells were counted in each field (40 × ), and five fields were used in ...positive ... See full document
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