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MicroRNA-196b-5p promotes malignant progression of colorectal cancer by targeting ING5
... MicroRNAs (miRNAs) are single-stranded, endog- enous and short non-coding RNA molecules [9, 10]. MiRNAs regulate gene expression through targeting 3 ′ -untranslated region (3 ′ -UTR) of their target genes, causing ... See full document
10
MiR-1307 promotes ovarian cancer cell chemoresistance by targeting the ING5 expression
... in colorectal cancer [24], we found that ING5 was a target gene of miR-1307 by means of chip analysis and Target Scan ...direct targeting was further supported through luciferase reporter ... See full document
11
Long noncoding RNA RHPN1-AS1 promotes colorectal cancer progression via targeting miR-7-5p/OGT axis
... inhibiting effect of sh-RHPN1-AS1#1 on RHPN1-AS1 in HCT-116 and HT29 cell lines was more visually than sh-RHPN1-AS1#2. Accordingly, sh-RHPN1-AS1#1 was used in next researches (Fig. 1b). Then, CCK-8 and EdU assays were ... See full document
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Original Article MiR-590-5p as potential oncogenic microRNA of human colorectal cancer cells by targeting PTEN
... Abstract: MicroRNA-590-5p (MiR-590-5p) has been proven dysregulated in some human malignancies such as he- patocellular carcinoma and cervical ...and progression of colorectal ... See full document
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MicroRNA-20a-5p promotes colorectal cancer invasion and metastasis by downregulating Smad4
... For negative regulation on Smad4, we further investigated whether Smad4 was the direct target of miR-20a-5p. We found wild type Smad4 3′-UTR mRNA contained a length of sequence conserved miR-20a-5p and ... See full document
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<p>MiR-195-5p Inhibits Malignant Progression of Cervical Cancer by Targeting YAP1</p>
... cervical cancer and is considered to be a tumor suppressor in this type of cancer, 17 and which is also highly accumulated in the nucleus of HPV-positive oropharyngeal squamous cell ... See full document
18
<p>ACAT2 Promotes Cell Proliferation and Associates with Malignant Progression in Colorectal Cancer</p>
... Acyl-coenzyme A (CoA): cholesterol acyltransferase (ACAT) is a membrane-bound enzyme localized in the endoplasmic reticulum which catalyzes cholesterol and long chain fatty acyl-CoA to produce cholesteryl ester. 6 These ... See full document
12
MicroRNA-301a promotes migration and invasion by targeting TGFBR2 in human colorectal cancer
... TGFBR2 is a major trans-membrane receptor of trans- forming growth factor-β (TGF-β). Upon binding with its ligand TGF-β, TGFBR2 is phosphorylated at the serine and threonine residues within its GS box, which could ac- ... See full document
6
MicroRNA-21-5p promotes proliferation of gastric cancer cells through targeting SMAD7
... SGC-7901 cells transfected with miR-21-5p mimics, inhibitors, and negative miRNA were grown for 24 h. The cells were centrifuged at 1,000 rpm for 5 min and washed with PBS. Then the cells were stained with Hoechst ... See full document
6
MicroRNA-106b promotes colorectal cancer cell migration and invasion by directly targeting DLC1
... of cancer tissue and adjacent normal mucosa (at least 5 cm from the margin of the tumor) were obtained from 95 patients with colorectal cancer who underwent surgery at The Affiliated Hospital of ... See full document
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Original Article MiR-148a suppresses invasion and induces apoptosis of breast cancer cells by regulating USP4 and BIM expression
... Total miRNA was extracted from cells in differ- ent groups using a mirVana miR Isolation Kit (Ambion, Shanghai, China) according to the manufacturer’s instructions. cDNA was syste- ms using a TaqMan MicroRNA ... See full document
158
Wnt/β-catenin signalling in ovarian cancer: Insights into its hyperactivation and function in tumorigenesis
... Epithelial ovarian cancer (EOC) is the deadliest female malignancy. The Wnt/ β -catenin pathway plays critical roles in regulating embryonic development and physiological processes. This pathway is tightly ... See full document
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<p>Circ_0005576 Promotes Malignant Progression Through miR-874/CDK8 Axis in Colorectal Cancer</p>
... conservation, and speci fi c expression in developmental stages. 4 Recent studies have shown that circRNAs func- tion as a “ sponge ” for miRNAs to block the inhibitory effect of miRNAs on downstream target gene ... See full document
14
microRNA-769 is downregulated in colorectal cancer and inhibits cancer progression by directly targeting cyclin-dependent kinase 1
... Total RNA was isolated from tissue samples and cultured cells using the TRIzol reagent (Invitrogen Life Technologies; Thermo Fisher Scientific, Inc., Waltham, MA, USA). For quantifying miR-769 expression, total RNA was ... See full document
6
Cancer-associated fibroblast-derived exosomal microRNA-98-5p promotes cisplatin resistance in ovarian cancer by targeting CDKN1A
... CAF-derived exosomes could lead to a significant pro- motion in cisplatin resistance in OC cells. Exosomes can be taken up by other cells, thereby being able to transfer biological messages to nearby cells, and this ... See full document
113
<p>miR-100-5p Inhibits Malignant Behavior of Chordoma Cells by Targeting IGF1R</p>
... IGF1R is a widely expressed transmembrane tyrosine kinase receptor and involved in many types of solid tumors, such as osteosarcoma, colorectal cancer, breast cancer, and prostate cancer. ... See full document
5
microRNA -140-5p inhibits colorectal cancer invasion and metastasis by targeting ADAMTS5 and IGFBP5
... on cancer cell type and expression method [30, 43 – 46]. In colon cancer, a study using the rat model revealed that IGFBP5 is one of the top up- regulated genes ...a cancer promoter based on our ... See full document
180
MicroRNA-378-5p suppresses cell proliferation and induces apoptosis in colorectal cancer cells by targeting BRAF
... USA) and 1 μg RNA was used for complementary DNA (cDNA) synthesis using the ReverTra Ace-α- (TOYOBO, Osaka, Japan) according to the manufacturer’s instruc- tions. Real-time PCR was performed using the SYBR® regent ... See full document
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MicroRNA-492 expression promotes the progression of hepatic cancer by targeting PTEN
... the progression of a very aggressive model of pancreatic ductal adenocarcinoma ...of cancer cells [3]. MiR-183 is dysregulated in breast cancer and its expression correlates with estro- gen receptor ... See full document
15
miR-125a-5p suppresses colorectal cancer progression by targeting VEGFA
... All experiments were performed in triplicate, and statis- tical analysis was performed using SPSS 19.0 software (Chicago, IL, USA). Differences between the two groups were evaluated using Student’s t-test (two-tailed), ... See full document
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