[PDF] Top 20 El impacto de la ley de violencia de género en la sociedad española
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Treatment of pancreatic cancer with epidermal growth factor receptor-targeted therapy
... insulin-like growth factor 1 receptor (IGF1R) ...insulin-like growth factor binding protein has been implemented in this ...a targeted anti-IGF1R TKI is effective in inhibiting ... See full document
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Biomarkers predicting resistance to epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer with wild-type KRAS
... colorectal cancer (mCRC). The advent of EGFR-targeted monoclonal antibodies panitumumab and cetuximab has generated promise for the treatment of mCRC and has largely improved patients’ ... See full document
24
Mutations in the epidermal growth factor receptor (EGFR) gene in triple negative breast cancer: possible implications for targeted therapy
... EGFR gene could confer structural conformational changes that render them unrecognizable by the antibo- dies; besides, there are also possibilities of mutations in other exons of the EGFR that were not probed in our ... See full document
5
Endophilin A2 promotes HER2 internalization and sensitivity to trastuzumab based therapy in HER2 positive breast cancers
... as epidermal growth factor receptor (EGFR) ...breast cancer progression, where an active leading edge and growth signaling promote cell motility and inva- ...in cancer ... See full document
7
Role of lapatinib in the first-line treatment of patients with metastatic breast cancer
... breast cancer. ErbB2, perhaps the most studied member of the type I receptor tyrosine kinase family, is overexpressed in approximately 20% of breast ...mal growth factor receptor (EGFR) ... See full document
6
<p>Targeting the MET-Signaling Pathway in Non-Small–Cell Lung Cancer: Evidence to Date</p>
... second-line treatment of metastatic non-small – cell lung cancers (NSCLCs) harboring an epidermal growth factor-receptor (EGFR) mutation or anaplastic lymphoma kinase (ALK) ...1–5 ... See full document
15
Quality of life outcomes including neuropathy-associated scale from a phase II, multicenter, randomized trial of eribulin plus gemcitabine versus paclitaxel plus gemcitabine as first-line chemotherapy for HER2-negative metastatic breast cancer: Korean Cancer Study Group Trial (KCSG BR13-11)
... human epidermal growth factor receptor 2 (HER2)- negative MBC (the Korean Cancer Study Group [KCSG] BR13-11, ...that treatment with EG resulted in similar outcomes as ... See full document
207
Mutations in the phosphatidylinositol 3 kinase pathway: role in tumor progression and therapeutic implications in breast cancer
... human epidermal growth factor receptor (HER)2 and other receptor tyrosine ...estrogen receptor (ER)+ breast cancer cells, PI3K activation promotes estrogen- dependent and ... See full document
15
<em>EGFR</em> mutations as a prognostic and predictive marker in non-small-cell lung cancer
... lung cancer (NSCLC) has entered the age of individual treatment, and increasing point mutations of specific oncogenes and rearrangement of some chromosomes are biomarkers used to predict the therapeutic ... See full document
5
Overexpression of the epidermal growth factor receptor in human pancreatic cancer is associated with concomitant increases in the levels of epidermal growth factor and transforming growth factor alpha
... The epidermal growth factor (EGF) receptor is activated by both EGF and transforming growth factor-alpha ...EGF receptor, EGF, and TGF-alpha are found in both ... See full document
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Original Article Temozolomide and targeted therapy against epidermal growth factor receptor in glioma
... standard therapy [3]. In vitro treatment with TMZ, carried out in glioma monolayer [31, 32] and in spher- oid three-dimensional cell cultures [33], showed that the drug induced time- and con- ... See full document
42
The progress of targeted therapy in advanced gastric cancer
... gastric cancer, making it the fourth most com- mon cancer and the second leading cause of cancer re- lated death worldwide with an estimated 800,000 deaths caused by the disease ...Chinese ... See full document
40
Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor signalling pathway
... breast cancer cells are completely dependent on oestrogen for ...oestrogen, growth is strongly ...the growth of these cells ...short treatment compared with mock-stimulated ... See full document
19
Targeted Drug Delivery and Image-Guided Therapy of Heterogeneous Ovarian Cancer Using HER2-Targeted Theranostic Nanoparticles
... Targeted cancer therapy utilizing surface receptors that are highly expressed on tumor cells has been used to treat human ...(human epidermal growth factor receptor 2) and ... See full document
5
Cancer therapy target: the epidermal growth factor receptor
... Gefitinib was originally approved in the US in 2003 and withdrawn in 2005 when it failed to comply with initial end point expectations. However gefitinib therapy has been more successful in Asian population ... See full document
32
<em>EGFR</em>, <em>KRAS</em>, <em>BRAF</em>, <em>PTEN</em>, and <em>PIK3CA </em>mutation in plasma of small cell lung cancer patients
... lung cancer (SCLC) is an aggressive and deadly neuroendocrine tumor derived from bronchial epithelial ...of targeted therapies for SCLCs has lagged ...in epidermal growth factor ... See full document
12
Clinical outcomes of epidermal growth factor receptor tyrosine kinase inhibitors in recurrent adenosquamous carcinoma of the lung after resection
... A retrospective review of patients from Shanghai Chest Hospital and Zhongshan Hospital, two institutions located in the eastern districts of People’s Republic of China, was performed between January 2006 and December ... See full document
10
Impact of epidermal growth factor receptor (EGFR) activating mutations and their targeted treatment in the prognosis of stage IV non small cell lung cancer (NSCLC) patients harboring liver metastasis
... EGFR targeted therapies in EGFR mutant NSCLC patients is not compromised in any way by the specific location of the ...continue treatment for longer periods benefiting more extensively from ... See full document
24
Vasculogenic mimicry is associated with trastuzumab resistance of HER2 positive breast cancer
... initially targeted for retrospective ...breast cancer patients, 27 patients re- ceived NAC without Tzm and 78 patients received NAC with Tzm (the first dose of 4 mg/kg followed by 2 mg/kg doses in 12 ... See full document
13
Relationship between epithelial-to-mesenchymal transition and the inflammatory microenvironment of hepatocellular carcinoma
... important factor involved in the occurrence and development of tumors [29, ...its receptor IL-6R, which consists of two polypeptide chains; a ligand-binding chain (GP80) and a signal con- duction chain ... See full document
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