[PDF] Top 20 Importância da participação popular nas ações de saúde
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Aptamers: Active Targeting Ligands for Cancer Diagnosis and Therapy
... of cancer cells.[129] Because aptamers and siRNA have the similar chemical compositions, they can be connected easily with each other through the ...expressed cancer cells, but also kept the gene ... See full document
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Generating Cell Targeting Aptamers for Nanotheranostics Using Cell-SELEX
... several cancer biomarkers had been ...selecting aptamers specific to whole live ...and cancer cells or multiple types of cancer cells, represent differences in molecular ...isolate ... See full document
126
Nanotechnology advances in upper gastrointestinal, liver and pancreatic cancer.
... the diagnosis and treatment are sorely needed to improve patient ...made therapy, nanotechnology offers an excellent opportunity for producing nanoparticles capable of targeting specific cancers with ... See full document
5
<p>Overcoming the Blood–Brain Barrier: Successes and Challenges in Developing Nanoparticle-Mediated Drug Delivery Systems for the Treatment of Brain Tumours</p>
... passive targeting (because of the leaky vascularization at the tumour site); inhibition of drug ef fl ux mechanisms in endothelial and cancer cells; and active targeting by exploiting carriers ... See full document
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<p>Aptamers as Versatile Ligands for Biomedical and Pharmaceutical Applications</p>
... functional aptamers include, but not limited to, gold/silver NPs, silicon NPs, carbon NPs, and selenium ...combinative therapy system resulted in signi fi cant necrocytosis of HeLa and Dox-resistant MCF-7R ... See full document
13
Toward a magic or imaginary bullet? Ligands for drug targeting to cancer cells: principles, hopes, and challenges
... at cancer cells with a single surface marker results in focusing only at a single population among mixed ones which are constantly changing and ...and diagnosis of a par- ticular cell type by a single ... See full document
19
Targeting hypoxic response for cancer therapy
... Cabozantinib (1-N-[4-(6,7-dimethoxyquinolin-4- yl)oxyphenyl]-1-N’-(4-fluorophenyl)cyclopropane-1,1- dicarboxamide) is an oral medicine that inhibits MET, RET, ROS1, NTRK1, and AXL. The inhibiting activities of ... See full document
104
Targeting nucleocytoplasmic transport in cancer therapy
... against transformed cells [126]. It is hypothesized that this selectivity is based on the interference with the pRb tumor suppressor. A truncated Anguinomycin analog was still capable of blocking nuclear export above ... See full document
80
Targeting MicroRNAs in Cancer Gene Therapy
... pancreatic cancer [22], breast cancer [23] and colon cancer ...by targeting the tumor suppressors such as phosphatase and tensin homolog (PTEN) and programmed cell death 4 (PDCD4) ...in ... See full document
78
Targeting hypoxic response for cancer therapy
... lung cancer and glioblastoma where it is able to induce vascular normalization and reducing hypoxia (leading to improved efficacy of conventional therapies) [131] nevertheless anti-angiogenic drugs have been shown ... See full document
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Orabi, Ahmed El-Sayed Abd El-Halem (2013): In vitro selection and characterization of single stranded DNA aptamers inhibiting the hepatitis B virus capsid-envelope interaction. Dissertation, LMU München: Tierärztliche Fakultät
... specific aptamers for MBD on the HBV capsid surface were selected using in vitro selection with counter selection from an initial pool of 6×10 15 different ssDNAs with a 25– nt central block of randomized ... See full document
5
Clinical targeting recombinant immunotoxins for cancer therapy
... successful therapy, because each type of cancer cell expresses different kinds of surface ...the targeting moiety and the high activity of the toxin moiety, which will induce development of ...of ... See full document
83
Kopp, Florian (2013): Novel insights into the role of microRNAs in chemoresistance, tumor progression and cancer therapy. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... published cancer stem cell-specific drug salinomycin was evaluated for its therapeutic ...inhibits cancer cell migration already at low ...migratory cancer cells with low miR-200c expression, which ... See full document
10
G-Quadruplex Targeting Ligands: a Hope and a New Horizon in Cancer Therapeutics
... These ligands show anti cell proliferative activity in human lung carcinoma (A549), human colorectal carcinoma (HT29) and then against breast cancer with IC 50 values in very low micromolar range 137 ... See full document
10
Poly(lactic-co-glycolic acid) nanoparticles conjugated with CD133 aptamers for targeted salinomycin delivery to CD133<sup>+</sup> osteosarcoma cancer stem cells
... The preparation procedure of the nanoparticles is shown in Figure 1. Briefly, SAL-NP was prepared with an emulsion/sol- vent evaporation method, and Ap-SAL-NP was prepared by conjugation of CD133 aptamers to ... See full document
9
CELL TARGETING IN ANTI-CANCER GENE THERAPY
... Generally, the approach is intended to confer a therapeutic or prophylactic effect. However, it may serve as a way of marking cancer or any target cells for later identification. Its application is based primarily ... See full document
12
Mucins in ovarian cancer diagnosis and therapy
... ovarian cancer, although their biolog- ical functions are not clearly ...the diagnosis and treatment of ovarian tumors which overexpress ...of targeting radioconju- gated molecules, improved tumor ... See full document
5
Materials Discovery by Crystal Growth: Synthesis, Structure Determination, Magnetic, and Optical Properties of Complex Lanthanide Containing Oxides, Oxyhydroxides, and Oxyfluorides
... Descriptive statistics were used to illustrate sample characteristics and differences between those with depression and those without depression. These statistics were also used to characterize antidepressant users and ... See full document
9
Gefitinib loaded DSPE PEG2000 nanomicelles with CD133 aptamers target lung cancer stem cells
... with ligands such as aptamers or antibodies have attracted extensive attentions, since they could improve the targeting efficacy of chemother- apy drugs [13 – ...[15]. Aptamers — o- ... See full document
21
Predictive biomarkers in precision medicine and drug development against lung cancer
... lung cancer is highly aggressive, and most (95%) SCLC patients are current or former smokers [13, ...adjuvant therapy is used for patients with stages II–III ...Early diagnosis is the major factor ... See full document
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