[PDF] Top 20 Una mirada situacionista en el aula y su entorno
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NMDA RECEPTOR ANTAGONISTS ATTENUATE TOLERANCE INDUCED BY MORPHINE AND NERVE LIGATION IN MICE
... selective NMDA receptor antagonists, (2) three, two or even a single injection of the NMDA antagonists prevented the development of tolerance and reduction of morphine ... See full document
15
THE INTERACTION OF LEVETIRACETAM’S ANALGESIA WITH MORPHINE INDUCED TOLERANCE IN TAIL-FLICK MICE MODEL
... that NMDA receptor antagonist such as MK-80 or cycloxygenase (COX) inhibitors are able to attenuate the development of morphine tolerance ...opioid tolerance development or ... See full document
19
Cingulate NMDA NR2B receptors contribute to morphine-induced analgesic tolerance
... NMDAR antagonists to reduce the develop- ment of tolerance has been extensively demonstrated ...of morphine toler- ance and reduced withdrawal behaviors without affecting acute analgesia ...The ... See full document
10
NMDA receptor antagonists attenuate intrathecal morphine-induced pruritus through ERK phosphorylation
... intrathecal morphine-induced pruritus for following reasons: 1) We found that compared with the control group, mice treated with ...intrathecal morphine ex- hibited elevated expression of ... See full document
23
N Methyl d Aspartate (NMDA) Receptor Blockade Prevents Neuronal Death Induced by Zika Virus Infection
... tion induced by ZIKV may also be useful and be used in combination with antiviral ...microgliosis induced by ZIKV in vitro and in vivo, without affecting the ability of ZIKV to replicate in the ... See full document
71
Lidocaine alleviates morphine tolerance via AMPK-SOCS3-dependent neuroinflammation suppression in the spinal cord
... chronic morphine treatment through microglial ...repeated morphine treatment (10 μg/10 μL, once daily for 7 days) resulted in the acti- vation of the microglia (Iba1 as a microglia marker), and 200 μg/10 μL ... See full document
9
Clinical Benefit of NMDA Receptor Antagonists in a Patient With ATP1A2 Gene Mutation
... Mutations in the ATP1A2 gene cause familial hemiplegic migraine type 2, alternating hemiplegia of childhood, and cerebellar function deficits, epilepsy, and mental retardation. These symptoms are likely related to ... See full document
5
Effects of Estrogen Receptor Modulators on Morphine Induced Sensitization in Mice Memory
... Male adult NMRI mice (bred in animal department, School of Pharmacy, with ISO17025 license) weighing 20.2–29.4 g were used in the present study. The animals were housed in a temperature/moisture controlled ... See full document
136
Effect of N-methyl-d-aspartate (NMDA) receptor antagonist combination as adjuvant to general anesthesia in functional endoscopic sinus surgery
... Functional endoscopic sinus surgery is a form of surgical intervention used for treatment of patients with nasal and paranasal sinus pathology and done under endo- scopic magnification in a narrow area where surgical ... See full document
22
Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations
... same mice with the β adren- ergic antagonist, nadolol, that does not cross the blood–brain ...Ts65Dn mice was partially rescued, but the interpretation is ambiguous because the increase in freezing was only ... See full document
12
Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia
... The function of NLRP3 inflammasome is crucial for the regulation of neuroinflammation mediated by microglia [19]. Therefore, compounds that inhibit the activation of NLRP3 inflammasome may contribute to the improvement ... See full document
294
Opioid receptor–triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia
... chronic morphine tolerance and ...to morphine leads to activation of astrocytes and microglia, increases in expression of various signaling receptors in their bodies, and release of proinflammatory ... See full document
11
Journal of Applied Pharmaceutical Science
... with morphine significantly blocked development of morphine tolerance (Mansouri et ...of tolerance. As the action of ellagic acid on opioid receptor is not confirmed, there are several ... See full document
17
VITEX AGNUS-CASTUS FRUIT EXTRACT RESTRAINS ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED TOLERANCE IN MICE
... on morphine tolerance but more investigations are needed to elucidate the precise ...with morphine which can produce therapeutic analgesia with lower dose of morphine would be of great ... See full document
5
Involvement of NMDA Receptor and Nitric Oxide Pathway in the Anticonvulsant Effect of Genistein in Ovariectomized Mice
... Intraperitoneal (i.p.) administration of genistein (10 mg/kg) was performed in three different time intervals (15, 30, 45 min). Then different doses of genistein (5, 10, 30 mg/kg, i.p.) was injected 30 min prior to ... See full document
156
POSSIBLE MECHANISM OF HYPERGLYCEMIA INDUCED DECREASE IN ANTINOCICEPTIVE EFFECT OF ANALGESICS IN RATS
... Diabetes induced neuropathic pain is recognized as one of the most difficult pain to treat and conventional analgesic are well known to be partially effective or ...diabetes induced decrease in the ... See full document
22
Paeoniflorin inhibits excitatory amino acid agonist and high dose morphine induced nociceptive behavior in mice via modulation of N methyl D aspartate receptors
... the NMDA receptor NR2B subunit is an important con- tributor to pain ...in mice [32]. Activation of NMDA receptors during formalin-induced nociception has been reported ...to ... See full document
12
Neuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8.
... Acute pain thresholds are increased in the DKO mice. A) Latency to respond in the hotplate test was not different between all groups. The P value for WT vs. Nav1.8 KO is 0.67, for WT vs. DKO is 0.72 and for Nav1.8 ... See full document
164
THE EFFECT OF HISTAMINE H1 RECEPTOR ANTAGONISTS ON THE MORPHINE INDUCED ANTINOCICEPTION IN THE ACUTE TRIGEMINAL MODEL OF NOCICEPTION IN RATS
... a negligible brain-accessibility. There is no approved evidence for its analgesic properties, but There are some evidences about its anti- inflammatory activity. Fexofenadine inhibits cytokine release from nasal ... See full document
21
Analgesic and Anti-allodynic Effects of Two Flavonoids in Partial Sciatic Nerve Ligation in Rat Model
... The Swiss albino rats were made anesthetized with anesthesia, thiopental sodium (35mg/kg, i.p.). The right hind leg of the rat was shaved along with lower back in its thigh region. The shaved area was sterilized with 70% ... See full document
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