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... prepared granules ranged from 26-31. The housner,s ratio for granules ranged from 1.18- 1.40, which shows good flow property as a result of increase in particle size owing to granulation. Tapped density of the granules ... See full document

... The aim of present study was to improve the solubility of pioglitazone HCl a practically insoluble antidiabetic drug by using liquisolid technique. The in vitro release pattern of liquisolid tablets and directly ... See full document

... In-vitro dissolution study was performed by using USP dissolution test apparatus (Apparatus II, Paddle type) at 50 rpm for 1, 2, 3, 4, 5, 6, 7, 8, 9 and 10 min. in 6.8 pH phosphate buffer. 10 ml samples were ... See full document

... phosphate buffer (pH ...the buffer of the stated pH. Then tablet was made to adhere to the flat end of a syringe by means of cyanoacrylate glue again and a nylon rope was attached to the other end of ... See full document

... of Esomeprazole were prepared by direct compression method after incorporating different superdisintegrants such as, crosscarmellose sodium (Ac-Di- Sol), crospovidone and sodium starch glycolate in different ...of ... See full document

... The in vitro dissolution studies were carried out using USP apparatus type II at 75 rpm. The dissolution medium consisted of 0.1N hydrochloric acid for the first 1 hour , then acetate buffer pH 3.0 to 4 hours and ... See full document

... The test was carried out in a rotating basket method specified in the USP XXIII dissolution tester (Electrolab, TDT-08L, India) at a rotation speed of 100 rpm in 900 ml dissolution medium at 37 ± 0.5 °C in media with pH ... See full document

... The In-vitro for the dissolution study was carried out in the USP (United state pharmacopeia) dissolution test apparatus type 2 known as Paddle dissolution apparatus, used phosphate buffer as dissolution medium as ... See full document

... Content uniformity [8, 9] : The amount of active ingredient(s) is determined by the method described in assay and amount of active ingredient is calculated. New method was used for determination of drug content given ... See full document

... Drugs that are significantly metabolized before absorption, either in the lumen or the tissue of the intestine can show decreased bioavailability from slower releasing dosage forms. Eg, Aloprenol was most extensively ... See full document

... Five tablets were selected randomly and average weight was calculated. Tablets were crushed in a mortar and accurately weighed amount of average tablet was taken from the crushed blend. Then, the samples were ... See full document

... Chromatography Method: The chromatographic conditions were optimized to provide acceptable resolution of the analytes present in the drugs. The mobile phase selection was based on the peak parameters, run time and ease ... See full document

... of preparation of Granules: Tadalafil dispersions were taken in mortar and pestle along with suitable diluents and mixed constantly until a dry is mix obtained (before mixing both the diluents and dispersions were ... See full document

... Nanospheres are the particles having the size range between 10-200 nm in diameter. Nanospheres can be amorphous or crystalline in nature and also they have the ability to protect the drug from enzymatic and chemical ... See full document

... final tablet must conform to tight qualifications on, for instance, content uniformity, stability, label claim, disintegration time and dissolution and it is known that all these are influenced by both the ... See full document

... The fingerprinting of KM was done using certain chromatographic conditions. [8] Chromatography was performed on a 10x10 cm pre activated HPTLC silica gel 60 F 254 plate. Samples were applied to the plate as 6 mm wide ... See full document

... optimised formulation transformed and interpreted at graphical interface constructed using various kinetic ...relese formulation in phosphate buffer pH ... See full document

... formation and drug diffusion into the gel layer and to the dissolution media Polymer erosion also plays a major role in releasing drug from these matrices. These considerations indicate that hydrophilic polymers have the ... See full document

... Aspirin and Celecoxib appear to decrease the danger of colorectal cancer in those at high risk. Celecoxib matrix tablet with natural polysaccharide was found to be effective in controlling the colon cancer. ... See full document

... 20 tablets were selected and were weighed collectively and individually. From the collective weight, average weight was calculated. Each tablet weight was then compared with average weight to ascertain whether it ... See full document