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An Australian perspective of the 1918–1919 influenza pandemic
... The public was stunned by the ferocity of the pandemic and newspapers fanned public unease with regular reports of cases and deaths and lurid descriptions of former plagues. There were reports of people waking ... See full document
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Spatial temporal excess mortality patterns of the 1918–1919 influenza pandemic in Spain
... 3 pandemic mortality waves in spring- summer 1918, fall 1918 and winter 1919 (Figure ...first pandemic wave in May-July 1918 generated relatively mild excess mortality rates ... See full document
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The reporting of the influenza pandemic, 1918 1920 in Hamilton, Ontario
... view influenza as a stepping-stone in the further bureaucratization of medical services which contributed to the creation of a Canadian federal health department in 1919 ...that influenza sufferers ... See full document
30
Analysis by Single-Gene Reassortment Demonstrates that the 1918 Influenza Virus Is Functionally Compatible with a Low-Pathogenicity Avian Influenza Virus in Mice
... The 1918-1919 “Spanish” influenza pandemic is estimated to have caused 50 million deaths ...past pandemic influenza viruses, including the 1918 virus, is crucial for ... See full document
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Time variations in the transmissibility of pandemic influenza in Prussia, Germany, from 1918–19
... of pandemic influenza with time. The time course of a pandemic is likely to be influ- enced by heterogeneous patterns of transmission and human factors that modify the frequency of infectious contact ... See full document
7
The evolution of pandemic influenza: evidence from India, 1918–19
... 13, 1918 shows the early regional peaks in the western province of Bombay, the south-eastern province of Madras, and a small area on the eastern coast of India near the important Hindu pilgrimage site of ...the ... See full document
101
A year of terror and a century of reflection: perspectives on the great influenza pandemic of 1918–1919
... human influenza virus in 1933, researchers have worked to develop an effective influenza vaccine ...Current influenza vaccines are reformulated seasonally and provide protection against circulating ... See full document
11
A Single N66S Mutation in the PB1-F2 Protein of Influenza A Virus Increases Virulence by Inhibiting the Early Interferon Response In Vivo
... pathogenic influenza A viruses have been widely studied due to their pandemic ...Spanish influenza pandemic of 1918 and ...avian influenza (HPAI) H5N1 virus poses a global health ... See full document
127
Genetic Requirement for Hemagglutinin Glycosylation and Its Implications for Influenza A H1N1 Virus Evolution
... Transmission of mutant viruses in guinea pigs. Transmissi- bility is a prerequisite for IAV to spread between individuals and to perpetuate itself in hosts (32, 33). The receptor specificity of HA has been also ... See full document
129
British policy and Bulgaria, 1918-1919.
... As has been seen, Stambolisky paid for his opposition to the war with a jail term.^^ Nevertheless, he continued to urge other Agrarians to work against it from his cell, whence he also had to deal with an attempt by a ... See full document
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Pulmonary immune responses to 2009 pandemic influenza A (H1N1) virus in mice
... However, the in vivo role of IL-17 in the clearance of influenza virus and its immune pathology has been con- troversial. Several studies have demonstrated the import- ant protective role of IL-17 against lethal ... See full document
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Perception and Performance of Preventive Behaviors for the Pandemic Influenza in Hospital Employees and Outpatients
... In summary, more than 75% of hospital employees and 65% of outpatients perceived the benefits of preventive be- haviors for H1N1 pandemic influenza and performed them. Factors related to the preventive ... See full document
6
Different Evolutionary Trajectories of European Avian-Like and Classical Swine H1N1 Influenza A Viruses
... the 1918 sequence in general occupies contiguous compositional space with classical swine and human A/H1N1 lineages, as would be expected because classical swine and human A/H1N1 viruses are direct descen- dants ... See full document
158
Contemporary Avian Influenza A Virus Subtype H1, H6, H7, H10, and H15 Hemagglutinin Genes Encode a Mammalian Virulence Factor Similar to the 1918 Pandemic Virus H1 Hemagglutinin
... Intriguingly, we also observed marked differences in the cyto- pathicity of these chimeric avian viruses in differentiated primary NHBE cells, demonstrating that expression of different HAs can directly affect cell death ... See full document
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The Receptor-Binding Domain of Influenza Virus Hemagglutinin Produced in Escherichia coli Folds into Its Native, Immunogenic Structure
... of influenza viruses, a recom- bination event occurred in which the gene for a primordial lectin molecule was incorporated into a membrane fusion do- main to provide sugar recognition abilities without compromis- ... See full document
170
"Will they just pack up and leave?" – attitudes and intended behaviour of hospital health care workers during an influenza pandemic
... perceived pandemic influenza to be very serious ...a pandemic, but nonetheless most were willing to work during a pandemic if a patient or colleague had ...against pandemic ... See full document
16
Human Dendritic Cell Response Signatures Distinguish 1918, Pandemic, and Seasonal H1N1 Influenza Viruses
... The increase in the global loss of mRNA beginning at 4 h after infection by the seasonal viruses is consistent with an increased rate of mRNA degradation. mRNA levels depend on both synthesis and deg- radation. Nuclear ... See full document
12
Founding Weimar: Violence and the German Revolution of 1918 1919
... conveying the uncertainty and trepidation felt by individuals, these sources also provide the narrative with a sense of immediacy and a perspective from below. Mark Jones, for instance, has employed the published ... See full document
215
Reconstruction of the 1918 Influenza Virus: Unexpected Rewards from the Past
... in pandemic influenza pre- paredness ...the 1918 virus through the National Select Agents Registry Program at the ...the 1918 virus has since gone forward at a rapid pace, leading to numerous ... See full document
19
Age prioritized use of antivirals during an influenza pandemic
... currently 4 months at best [24]. Other estimates are 6 months at best [25,26]. Remarkably, according to these estimates the pandemic vaccine will be available in time only in case of a mild epidemic (see Figure ... See full document
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