[PDF] Top 20 Previsão de demanda em uma fábrica de sorvetes
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Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis.
... in mitosis compared to untreated cells ...aberrant mitosis (21 of 24 cells), whereas death in G1 typically occurred after two aberrant mitoses (19 of 29 ...aberrant mitosis (both a cytostatic and ... See full document
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Aurora B prevents premature removal of spindle assembly checkpoint proteins from the kinetochore: A key role for Aurora B in mitosis.
... thus kinetochore accumulation, followed by stripping upon NDGA treatment takes time (Supplementary ...the kinetochore and centrosome localization of dynein-bound MAD1 following treatment with AZD1152, but ... See full document
5
Rapid removal of TACC3–ch-TOG–clathrin from kinetochore fibres during mitosis
... mitotic spindle undergoes functional maturation until the satisfaction of the spindle assembly checkpoint (SAC), which prevents anaphase until all chromosomes have formed bipolar ... See full document
10
Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development
... of aurora B (Ruchaud et ...and kinetochore function, being responsible for the recruitment to the kinetochore and centromere of a growing number of proteins, including inner centromeric ... See full document
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Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design
... of Aurora-A in the AurA x3 /MLN8054 complex exhibits an unusual conformation in which Asp274 and Phe275 sidechains point into the interior of the ...to Aurora-A switches the character of a pocket within the ... See full document
13
Original Article Let-7g reverses malignant phenotype of osteosarcoma cells by targeting Aurora-B
... One member of let-7 cluster was the first identi- fied human miRNA in 2000 by Reinhart [17]. Numerous members of the let-7 cluster have been identified in various species [18]. So far, 11 mature subtypes of the let-7 ... See full document
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Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases
... heated from 0 to 300 K in 500 ps at constant volume and equilibrated at 300 K for another 500 ...and Aurora A/B. For the current work, 200 snapshots extracted from the last 10 ns of MD trajec- ... See full document
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Self-organization of intracellular gradients during mitosis
... them to create a FRET biosensor sensitive to changes in the mobility of the amino terminal tail. They not only show that RCC1 binding to DNA is dependant on the amino terminal tail and its methylation, but that RCC1 ... See full document
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A novel role for Skp2 in mitotic entry
... into mitosis, and that it physically associates with Cyclin A and protects Cyclin A from premature destruction (Das et ...into mitosis, we had found that Skp2 null cells have a lower mitotic ... See full document
8
Assessing the role of Ku70 vWA domain phosphorylation in the inhibition of Aurora B and activation of the DNA damage response
... through Aurora B ...to Aurora B inhibition which in turn causes the DDR had not been ...an Aurora B inhibitor resulted in the activation of the DDR, as characterized by the ... See full document
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Proceedings of 2015 Aurora Scientific Day
... obtained from the EHR on the day of and the day prior to researcher assessment: 1) hypoactive delirium (any one of the following: nurse’s assessment of motor retardation or reduced level of consciousness or ... See full document
8
Regulation of the Cell Division Cycle in Trypanosoma brucei
... differ from the checkpoints in humans and between the different life cycle ...as Aurora B kinase, Polo-like kinase, and CDKs in fungi and animals (38, 48, 49, 57, ... See full document
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Inhibition of Aurora B by CCT137690 sensitizes colorectal cells to radiotherapy
... [9,11]. Aurora A overexpression has been observed in vari- ous cancers including colorectal ...of Aurora A protein in 19% of CRC by immunohistochemistry ...the Aurora A gene was found in colorectal ... See full document
12
Expression of Aurora Kinase A and B in chondrosarcoma and its relationship with the prognosis
... The Aurora Kinase B is the component of the chromosome passenger protein complex which partici- pate in the chromosome condensation, spindle assembly, segregation of sister chromatids and ... See full document
16
EBNA3C regulates p53 through induction of Aurora kinase B
... anticipation that the K 111 M mutant would have stability between that of the wild type AK-B and its kinase-dead mutants. Additionally, a mutation at K 207 R, the residue required for AK-B SUMOylation gives ... See full document
87
Aurora A: an expedition to the pole of the spindle in Xenopus egg extracts
... prepared from insect cells (Sf9) or from bacteria ...assay. Aurora-A purified from Sf9 had to be treated with okadaic acid to inhibit the phosphatase PP1 that co-purified with the kinase, ... See full document
5
CSN6 deregulation impairs genome integrity in a COP1- dependent pathway
... in mitosis such as Aurora A kinase will be ...including Aurora kinase A, providing explanation to COP1-mediated genome instability and a possible plethora of functions of ... See full document
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Evaluation of the Aurora Kinase Inhibitor, ZM447439, in Canine Malignant Lymphoid Cells in Vitro
... anti-human aurora-A (1:1000 dilution; polyclonal goat antibody, Tocris Biosci- ence, Ellisville, MO), and anti-human aurora-B (1:1000 dilution; polyclonal rabbit antibody, Abcam, Cambridge, MA) ... See full document
6
A centrosomal view of CNS growth
... mitotic spindle relative to the cell cortex during cell division (Negishi et ...motor proteins of the dynein/dynactin complex, pulls on astral microtubules; this, in turn, drives mitotic spindle ... See full document
18
The Aurora B Kinase Promotes Inner and Outer Kinetochore Interactions in Budding Yeast
... with spindle microtubules during cell division (Westermann et ...The kinetochore is composed of multiple copies of distinct subcomplexes that assemble into a macromolecular structure estimated to be ... See full document
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