[PDF] Top 20 Procedimiento para la determinación de los procesos para la gestión del desarrollo local en el Gobierno de Villa Clara
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Synthesis, biological activity and molecular docking of new tricyclic series as α-glucosidase inhibitors
... active site of the α-glucosidase enzyme (Fig. 5). Acar- bose can establish 10 hydrogen bonds with Asp232, Ala234, Asn237, Asp357, Arg552, Asp568 and His626. Moreover, two hydrophobic interactions are ... See full document
261
Synthesis of new DPP 4 inhibitors based on a novel tricyclic scaffold
... DPP-4 activity when compared to sitagliptin (IC50 22±2 ...of biological activity when compared to the trans-isomer (for example compare 12a and 12b and 17 and ...in activity, demonstrating ... See full document
47
Synthesis, biological evaluation and docking of novel bisamidinohydrazones as NON-peptide inhibitors of furin
... a series of novel non-peptidic furin inhibitors with values of inhibitory constants (Ki) in the range of ...moieties. docking studies of these new inhibitors into recently published ... See full document
17
Molecular Docking Investigation of New Inhibitors of Falciparum vivax
... tential inhibitors for Pv NMT As discussed in the previous section, these com- pounds can also aid further validation of Pv NMT as an ideal target protein by demonstrating selective inhibition which subsequently ... See full document
53
Synthesis, Biological Evaluation and Molecular Docking Studies of Novel 1,8-Naphthyridine-3-carboxylic Acid Derivatives as Potential Antimicrobial Agents (Part-1)
... Reference preparations of derivatives were in dimethyl sulphoxide (DMSO) at 10X concentrations and covered a full range of 50-2000 μg/ml. This method was convenient and economical for pipette use. Bacto agar was used as ... See full document
6
In silico Molecular Docking and Molecular Dynamics Applications in the Designing of a New Mosquito Repellent from the Plant Calotropis gigantea Targeting the Odorant Binding Protein of Culex quinquefasciatus
... many biological processes such as signal transduction, cell regulation, and other m acromolecular ...in molecular recognition is crucial in understanding the interaction mechanisms and to design therapeutic ... See full document
19
Search | Preprints
... Now-a-days cardiovascular diseases (CD) like coronary heart disease CHD, atherosclerosis, hypertension and acute myocardial infarction are main causes of death in humans. Among all kind of these CD, thrombosis is one of ... See full document
10
Design, synthesis, and antifungal activities of novel triazole derivatives containing the benzyl group
... a series of 1-(1H-1,2,4-triazole-1-yl)-2- (2,4-difluorophenyl)-3-substituted-2-propanols (1a–r), which were analogs of fluconazole, was designed and synthesized by click ...antifungal activity than the ... See full document
7
Quinazoline derivatives: synthesis and bioactivities
... anti-obesity activity of quinazoline derivatives, which were determined as MCHR1 antagonists ...A series of compounds were obtained by the change of substituent groups, including 4-propyl-quinazolinone, 4- ... See full document
192
Inhibitory Reactivity of Capsaicin with α-Amylase and α-Glucosidase Related to Antidiabetes using Molecular Docking and Quantum Calculation Methods
... the molecular configuration of the inhibitor ...their molecular water solvation among the active sites of the enzyme and the inhibitor ...this molecular docking and quantum calculation with ... See full document
8
HMG-CoA Reductase Inhibitory Activity of Gnetum gnemon Seed Extract and Identification of Potential Inhibitors for Lowering Cholesterol Level
... pharmacological activity, such as: to reduce the level of sugar in the blood, show anti-inflamatory activity and induce apoptosis in colon ...inhibitory activity in silico and in ... See full document
6
Synthesis, Biological Evaluation, and Docking Analysis of Methyl Hydroquinone and Bromo Methyl Hydroquinone as Potent Cyclooxygenase (COX-1 and COX-2) Inhibitors
... NSAIDs work by reducing the production of prostaglandins. Prostaglandins are chemicals which not only promote inflammation, pain, and fever but also protect the lining of the stomach and intestines from the damaging ... See full document
12
α-Glucosidase inhibitors from the bark of Mangifera mekongensis
... Mangifera mekongensis (Anacardiaceae), commonly known as mango, is widely distributed in tropical and sub- tropical regions of Asia. In Vietnam, M. mekongensis is called as “Xoai Thanh Ca”, and this plant is cultivated ... See full document
20
Synthesis and Evaluation of New Substituted Pyrazoline Derivatives as Biological Agents
... antimicrobial activity. The compound P 25 , P 29 and P 32 showed promising activity against Staphylococcus aureus where as other compounds showed moderate to poor ...significant activity against ... See full document
6
“IN SILICO STUDIES OF INDAZOLE PYRIDINE ANALOGS AS POTENT IHIBITORS OF AKT PROTEIN IN CANCER” by N Blessy Christina, Manoj Kumar Mahto, Khunza Meraj, Prof. M Bhaskar, India. Digital copy link
... A series of invention of AKT inhibitors lead to the discovery of Indazole pyridine ...by docking against the target (AKT) using GOLD. From docking analysis, we found that substitutions like ... See full document
23
Synthesis, molecular docking and design of Tetrahydroquinolines as acetylcholinesterase inhibitors
... One important characteristic that any biologically active compound should have for being a candidate drug is the ability to cross biological membranes. Also, and in accordance with the above; a molecule must ... See full document
16
DESIGN, SYNTHESIS, DOCKING STUDIES AND BIOLOGICAL EVALUATION OF NOVEL HYDROXAMIC AND CARBOXYLIC ACID DERIVATIVES AS HISTONE DEACETYLASE ENZYME INHIBITORS
... A new series of hydroxamic (5a-5j) and carboxylic acid analogs (4a-4j) based on the 1, 3, 4-thiadiazole scaffold was designed and synthesized to explore its potential as new antitumor ...analysis. ... See full document
20
Synthesis of novel Triazinoindole-Based-Thiourea Hybrid: -Glucosidase Inhibitors and Their Molecular Docking Study
... M. Synthesis and in vitro Acetylcholinesterase and Butyrylcholinesterase Inhibitory Potential of Hydrazide based Schiff ...M. Synthesis of new arylhydrazide bearing Schiff bases/thiazolidinone: ... See full document
35
In Silico Docking Analysis of A-type Proanthocyanidins to α-Glucosidase Constructed by Correlation with in Vitro Bioassay
... catalytic activity (D518 and D616) ...good docking compounds such as 2 in Tables 1 and 3, the oxygen atom of the 3-OH in unit I formed an ionic bond with the guanidinium nitrogen of A600 in AG (Figure 3A), ... See full document
5
INSILICO DESIGN AND MOLECULAR DOCKING STUDIES OF NOVEL 1, 2, 4- TRIAZOLE DERIVATIVES AS CYP-51 INHIBITORS
... 5. Martha De La Rosa, Hong Woo Kim, Esmir Gunic, Cheryl Jenket, Uyen Boyle, Yung hyo Koh, Ilia Korboukh, Matthew Allan, Weijian Zhang, Huanming Chen, Wen Xu, Shahul Nilar, Nanhua Yao, Robert Hamatake, Stanley A. Lang, ... See full document
6
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