[PDF] Top 20 La responsabilidad penal médica: cuestión de ética o de derecho
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Design of pH-sensitive methotrexate prodrug-targeted curcumin nanoparticles for efficient dual-drug delivery and combination cancer therapy
... and pH-responsive prodrug was successfully synthesized via Schiff’s base reaction between MTX and ...MTX-Imine-M nanoparticles encapsulating CUR drug within their hydrophobic DSPE ... See full document
9
Control of targeting ligand display by pH responsive polymers on gold nanoparticles mediates selective entry into cancer cells
... selected gold nanoparticles (AuNPs) as nanoscale constructs to prove the concept that drug delivery systems can be ‘instructed’ to operate sequential tasks that are crucial to target ... See full document
25
<p>Co-Delivery of Paclitaxel and Doxorubicin by pH-Responsive Prodrug Micelles for Cancer Therapy</p>
... anticancer drug molecules would be cleared quickly by the reticuloendothelial system (RES) and blood/renal during circulation in the body after administration, leading to the quite low concentration at the tumor ... See full document
5
Recent Developments in the Application of Polymeric Nanoparticles as Drug Carriers
... pullulan-based nanoparticles using MTT ...of polymer modification, concentration or incubation ...methacrylate)/biosurfactant nanoparticles upon incubation with peripheral blood mononuclear cells ... See full document
121
Recent Trends in Biomedical Applications of Nanomaterials
... photothermal therapy that effectively reduced tumors in an animal ...and pH- sensitive disulfide-bond linked HA that exerts an activity with multiple effects: thermo and chemotherapeutic, real-time ... See full document
14
<p>Enhanced and Prolonged Antitumor Effect of Salinomycin-Loaded Gelatinase-Responsive Nanoparticles via Targeted Drug Delivery and Inhibition of Cervical Cancer Stem Cells</p>
... target cancer cells and CSCs through a gelatinase- stimuli ...a delivery system for docetaxel or 5- fl ...the delivery of Sal to improve its solubility, which further contributes to increased ... See full document
7
<p>Mitoxantrone-preloaded water-responsive phospholipid-amorphous calcium carbonate hybrid nanoparticles for targeted and effective cancer therapy</p>
... the drug in the PL/ACC-MIT group penetrates more deeply into the MCTS, as the MIT signal could still be clearly observed even at 60 µ m below the maximum ...of nanoparticles from superficial to in-depth of ... See full document
30
<p>Tumor Targeted Curcumin Delivery by Folate-Modified MPEG-PCL Self-Assembly Micelles for Colorectal Cancer Therapy</p>
... Colorectal cancer (CRC) is the third most common tumor and one of the main causes of cancer-related death among both men and women ...chemotherapy, targeted therapy, radiotherapy and ... See full document
19
<p>Targeted Prodrug-Based Self-Assembled Nanoparticles for Cancer Therapy</p>
... The design of prodrug-based DDS aims to enhance the PTX drug release half-life and tumor site retention time and reduce the side effect toxicity of free PTX to normal ...In vivo pharmacokinetic and ... See full document
10
Highly effective photothermal chemotherapy with pH-responsive polymer-coated drug-loaded melanin-like nanoparticles
... and pH-responsive polymer-coated drug-loaded PDA nanoparticles (NPs; doxorubicin@ poly(allylamine)-citraconic anhydride [Dox@PAH-cit]/PDA NPs) were ...low pH condition, ... See full document
5
<p>Doxorubicin-Loaded Carbon Dots Lipid-Coated Calcium Phosphate Nanoparticles for Visual Targeted Delivery and Therapy of Tumor</p>
... the pH- sensitive release in the tumor microenvironment, which can increase the local concentration of chemotherapeutic drugs to enhance therapy in the acidic tumor ...the drug- loading ef fi ciency, ... See full document
43
<p>A review of small molecules and drug delivery applications using gold and iron nanoparticles</p>
... (Cur) delivery and cell imaging by immobilizing Au-NPs on FA-modified, dendritic, meso- porous, silica-coated, reduced graphene oxide nanosheets ...high drug loading ...and ... See full document
13
<p>Combination Treatment of Cervical Cancer Using Folate-Decorated, pH-Sensitive, Carboplatin and Paclitaxel Co-Loaded Lipid-Polymer Hybrid Nanoparticles</p>
... decorated nanoparticles (by conjugating speci fi c ligands) could potentially be delivered to speci fi c organs, tissues, cells, or even cellular ...14 Nanoparticles sur- face modi fi ed with different ligands ... See full document
5
pH-responsive polymer microcapsules for targeted delivery of biomaterials to the midgut of Drosophila suzukii
... in pH, a series of in vitro and in vivo experiments were ...in pH with an estimated pKa of ...low pH, we observed the microcapsules using an optical microscope as they were intro- duced to a ... See full document
8
Truebenbach, Ines (2019): Drug delivery systems for pretubulysin-based combination chemotherapies. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... PT+MTX drug incorporation into 454 nanomicelles upon exposure to (A) 154 mM NaCl solution and (B) 10% serum containing HBG at room ...For nanoparticles incubated in physiological NaCl solution (A), filters ... See full document
27
<p>Folate-Mediated Targeted Delivery of siPLK1 by Leucine-Bearing Polyethylenimine</p>
... approximately 50% cell viability could still be observed in NP/NPF treated SGC cell cells. This phenomenon indicated that compared with PEI, NP and NPF have lower cytotoxi- city, especially in normal cells. Therefore, ... See full document
8
<p>New Aspects of Ultrasound-Mediated Targeted Delivery and Therapy for Cancer</p>
... immunotherapy. 122–125 DCs are well known as antigen- presenting cells that activate antigen-speci fi c T cell responses. DCs can be modi fi ed to present tumor-derived antigens to T cells. Thus harnessing the patient ’ s ... See full document
133
<p>ROS-Responsive Chitosan Coated Magnetic Iron Oxide Nanoparticles as Potential Vehicles for Targeted Drug Delivery in Cancer Therapy</p>
... brain, breast, ...magnetic nanoparticles synthe- sized by traditional co-precipitation methods, and some stu- dies have proved that a strong chemical bond is formed between carboxylic acid and amorphous ... See full document
5
Prepare and Characterization of Polymer Coat Gold Nanoparticles and Their Application in Targeted Drug Delivery for Breast Cancer
... Chitosan–metal nanoparticles are another sort of molecule that has shown the capacity to enhance antimicrobial and pharmacodynamic movement when contrasted and metal nanoparticles without chitosan ... See full document
20
<p>Targeted Therapy for Hepatocellular Carcinoma: Co-Delivery of Sorafenib and Curcumin Using Lactosylated pH-Responsive Nanoparticles</p>
... in vivo anti-tumor ef fi - cacy of the nanoparticles (Figure ...all drug contained treatment groups signi fi cantly inhibited the tumor ...single drug contained nanoparticles, and free ... See full document
10
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