[PDF] Top 20 La sostenibilidad de la política fiscal en el Perú: 1970-2005
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<p>Icariin Alleviates IL-1β-Induced Matrix Degradation By Activating The Nrf2/ARE Pathway In Human Chondrocytes</p>
... from chondrocytes (1×10 6 /well in a 6-well plate) using a TRIzol kit (Invitrogen, USA) accord- ing to the manufacturer ’ s ...These chondrocytes were pretreated with NAC (10 mM) or ICA (10 − 9 M) ... See full document
9
Sesamin inhibits IL-1β-stimulated inflammatory response in human osteoarthritis chondrocytes by activating Nrf2 signaling pathway
... on IL-1β-stimulated human osteoarthritis chondrocytes and investigated the possible ...production induced by IL- ...in IL-1β-stimulated chondrocytes. Sesamin also ... See full document
22
<p>Curcumin Attenuates Oxaliplatin-Induced Liver Injury and Oxidative Stress by Activating the Nrf2 Pathway</p>
... ligand 1 (CXCL1), forward 5 ʹ -GGCTGGGATTCACCTCAAG-3 ʹ and reverse 5 ʹ -GCGACCATTCTTGAGTGTG-3 ʹ ; chemokine (C- X-C motif) ligand 2 (CXCL2), forward 5 ʹ -CCAACCAC CAGGCTACAGG-3 ʹ and reverse 5 ʹ -GCGTCACACTCA ... See full document
262
<p>Loratadine Alleviates Advanced Glycation End Product-Induced Activation of NLRP3 Inflammasome in Human Chondrocytes</p>
... When NRF2 was silenced in chondrocytes, loratadine lost all of its inhibitory effects on NLRP3 in fl am- masome activation, suggesting that chondrocyte NRF2 is an upstream signal of the NLRP3 in fl ... See full document
7
Original Article Suppression of microRNA-128 attenuates high glucose-induced podocyte apoptosis through activation of Nrf2-ARE signaling pathway
... apoptosis induced by high glucose (HG) remains largely ...was induced by HG in cultured podocytes in ...stress induced by HG. Nuclear factor erythroid 2-related factor 2 (Nrf2) was identified ... See full document
83
<p>Baicalin Protects Human OA Chondrocytes Against IL-1β-Induced Apoptosis and ECM Degradation by Activating Autophagy via MiR-766-3p/AIFM1 Axis</p>
... primary human articular ...and IL-1 β -stimulated articular chondrocytes, and IL-1 β -induced apoptosis of articular chondrocytes could be rescued by miR-27a ...in ... See full document
6
LncRNA MALAT1/MiR 145 Adjusts IL 1β Induced Chondrocytes Viability and Cartilage Matrix Degradation by Regulating ADAMTS5 in Human Osteoarthritis
... cultured chondrocytes was extracted with RIPA Reagent (Beyotime Institute of Biotechnology, Jiangsu, China) and analyzed by Western ...for 1 h, the membranes were visualized using enhanced chemilumi- ... See full document
14
Original Article MicroRNA-497-5p attenuates IL-1β-induced cartilage matrix degradation in chondrocytes via Wnt/β-catenin signal pathway
... signaling pathway can induce the expression of MMP ...produce matrix-degrading enzymes, such as MMP 13 and ADAMTS4, and stop synthesis of cartilage matrix molecules, including type II collagen and ... See full document
671
Interleukin 1 suppresses expression of cartilage specific types II and IX collagens and increases types I and III collagens in human chondrocytes
... contrast, IL-1 increased synthesis of types I and III collagens and levels of alpha 1(I), alpha 2(I), and alpha 1(III) procollagen mRNAs, as we described previously using human ... See full document
62
<p>Gasdermin D Hypermethylation Inhibits Pyroptosis And LPS-Induced IL-1β Release From NK92 Cells</p>
... Figure 1 DMF and MMF inhibit the production and release of LPS-mediated IL-1β release from NK92 ...of IL-1β mRNA. *P values ...of IL-1β among LPS-stimulated cells and those treated with ... See full document
16
<p>Amine derivatives of furocoumarin induce melanogenesis by activating Akt/GSK-3β/β-catenin signal pathway</p>
... was obtained from Generay Biotech (Shanghai, China), 8-MOP (CAS:298-81-7) was obtained from Sigma Aldrich (Milan, Italy), and Akt inhibitor IV was obtained from EMD Biosciences (La Jolla, CA, USA). 6-Bromoindirubin- 3 ′ ... See full document
8
<p>Chlorogenic Acid Alleviates Aβ<sub>25-35</sub>-Induced Autophagy and Cognitive Impairment via the mTOR/TFEB Signaling Pathway</p>
... Notes: (A) The viability of cells treated with various concentrations of CGA for 24 and 48 h was determined with MTT assay. (B) Representative MDC-stained autophagy vesicles in SH-SY5Y cells (right panel, ×200), and ... See full document
29
E2 regulates MMP 13 via targeting miR 140 in IL 1β induced extracellular matrix degradation in human chondrocytes
... with 1 mg/mL collagenase (Sigma-Aldrich, ...remove matrix debris, and cells were collected by centrifugation at 800 × g for 10 ...minutes. Chondrocytes were then re- suspended in Dulbecco’s modified ... See full document
6
Ozone induces autophagy in rat chondrocytes stimulated with IL-1β through the AMPK/mTOR signaling pathway
... signaling pathway was involved in ozone-induced autophagy in chondrocytes stimulated with IL-1 β ...ozone induced AMPK phosphorylation and suppressed mTOR phosphorylation in ... See full document
8
<p>Curcumin Supplementation Alleviates Polymyxin E-Induced Nephrotoxicity</p>
... In another study, evaluating the protective effects of curcumin in gentamicin-induced nephrotoxicity, it was shown that the positive effects of curcumin are due to the reduction of oxidative stress. Curcumin could ... See full document
28
<p>PFND1 Predicts Poor Prognosis of Gastric Cancer and Promotes Cell Metastasis by Activating the Wnt/β-Catenin Pathway</p>
... As with other cancers, GC remains a highly heterogeneous disease with poor prognosis. Over the past decades, although the comprehensive treatment of GC has devel- oped rapidly; most af fl icted individuals do not survive ... See full document
11
<p>Silencing of estrogen receptor β promotes the invasion and migration of osteosarcoma cells through activating Wnt signaling pathway</p>
... Figure 6 The growth and metastasis of OS tumors in mice. (A) Subcutaneous tumors under naked eye; (B) subcutaneous tumor volumes at different time points; (C) protein brands of Western blot; (D) relative expression of ... See full document
83
<p>Changes In Plasma NPY, IL-1β And Hypocretin In People Who Died By Suicide</p>
... persons. 1 The risk factors related to suicide include war, disaster, discrimination, abuse, violence, mental disorders, poor physical health and fi nancial ... See full document
160
miR-21-5p protects IL-1β-induced human chondrocytes from degradation
... cartilage degradation is a hallmark of OA and is believed to be largely mediated by proteases be- longing to the matrix metalloproteinase (MMP) and a disintegrin and metalloproteinase with thrombospondin ... See full document
39
Original Article Matrine inhibits IL-1β-induced expression of matrix metalloproteinases by suppressing the activation of MAPK and NF-κB in human chondrocytes in vitro
... extracellular matrix macromolecules and decreased expression of chondrocyte pro- tein and resulted in severe joint pain, loss of movement, and progressive irreversible dys- function ...that matrix metal- ... See full document
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