[PDF] Top 20 The Emotional Education in Infantile Education
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Targeted therapy for HER2 positive breast cancer
... trastuzumab therapy remains an important ...Antonio Breast Cancer Symposium and published by Goldhirsch et ...with HER2 positive early breast cancer to trastuzumab (T) ... See full document
6
<p>Efficacy and safety of targeted therapy for metastatic HER2-positive breast cancer in the first-line treatment: a Bayesian network meta-analysis</p>
... status, HER2 status, prior treatment, disease sites, percentage of measurable disease, and Eastern Cooperative Oncology Group performance status), duration of follow-up, primary outcomes (PFS and OS), secondary ... See full document
30
Role of pertuzumab in the treatment of HER2-positive breast cancer
... the HER2 receptor, represents a promising new anti-HER2 agent with a novel mechanism of action targeting the inhibition of HER2 ...broader HER2 blockade through the inhibition of HER2 ... See full document
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Dual HER2 blockade in the neoadjuvant and adjuvant treatment of HER2-positive breast cancer
... of breast tumors and has been associated with poor ...of HER2-positive breast cancer. Dual HER2 blockade, using agents that work in a complimentary fashion to trastuzumab, has ... See full document
24
Novel HER2 Aptamer Selectively Delivers Cytotoxic Drug to HER2 positive Breast Cancer Cells in Vitro
... Tumor-targeted therapy requires ligands that can bind to cancer ...prostate cancer in mice when administered systemically ...the cancer-specific cytotoxicity both in vitro and in vivo ... See full document
14
Efficacy and safety analysis of trastuzumab and paclitaxel based regimen plus carboplatin or epirubicin as neoadjuvant therapy for clinical stage II-III, HER2-positive breast cancer patients: a phase 2, open-label, multicenter, randomized trial
... (HER2- positive) subtype [6, 8, 9, ...with HER2- positive breast cancer ...of HER2-potitive breast cancer express p95HER2, which is resistant to ...HR ... See full document
167
Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapy
... common breast cancer cell ...are Her2+. To address the significance of p27 mislocalization in Her2+ breast cancer cells we interrogated the cellular response to the ... See full document
30
Comparative efficacy of different targeted therapies plus fulvestrant for advanced breast cancer following progression on prior endocrine therapy: a network meta-analysis
... Results: A total of 11 studies, including 4,178 patients in the network meta-analysis, were included and analyzed. In terms of the pooled hazard ratios (HRs) for PFS, palbociclib plus fulvestrant was superior to other ... See full document
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Development of<sup> 99m</sup>Tc-radiolabeled nanosilica for targeted detection of HER2-positive breast cancer
... on the binding capacity of SiNPs, the study was performed comparing SiNP vs SiNP-TZ and SiNP-NTA vs SiNP- NTA-TZ (Figure 2). Each kind of nanoconjugate was sepa- rately incubated for different time periods (20 min, 1 h, ... See full document
9
ctDNA dynamics: a novel indicator to track resistance in metastatic breast cancer treated with anti-HER2 therapy
... of HER2 CNV fluctuation was not captured in a considerable fraction of patients (6/14, ...of breast cancer-related genes and revealed resistance-related events other than HER2 ... See full document
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Polymer–lipid hybrid anti-HER2 nanoparticles for targeted salinomycin delivery to HER2-positive breast cancer stem cells and cancer cells
... against breast CSCs was also evaluated (Figure 6D, E, and ...against breast CSCs and induced a 4-fold decrease in BT-474 tumorsphere number relative to the saline control (Figure ...+ breast ... See full document
6
Appendicitis caused by the metastasis of HER2-positive breast cancer
... an HER2-positive primary tumor and HER2-negative meta- static tumor account for ...an HER2- negative primary tumor and HER2-positive metastatic tumor account for ... See full document
24
PYK2 promotes HER2-positive breast cancer invasion
... that HER2+/ER−/PR- cancer cells were the most resistant to ...ductal breast cancer, and this correlated with increased expression of HER2 ...in HER2+/ER−/PR- cancer cell ... See full document
6
Neratinib overcomes trastuzumab resistance in HER2 amplified breast cancer
... of HER2. It has been shown to increase survival in HER2 positive metastatic and early breast cancer patients, especially when given in combination with chemotherapy [10, ...of ... See full document
14
Activating Mutations in ERBB2 and Their Impact on Diagnostics and Treatment
... on cancer,” cancer remains one of the major causes of human morbidity and ...of targeted therapies holds the most promise for the future, making identification of tumor-specific therapeutic targets ... See full document
139
New developments in the treatment of HER2-positive breast cancer
... a HER2 expression plasmid (MCF7/HER2) showed higher binding of the HER2-affitoxin molecule relative to MCF7 parental ...BT474 breast cancer cells, which have endogenous overexpression ... See full document
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Constitutive phosphorylated STAT3-associated gene signature is predictive for trastuzumab resistance in primary HER2-positive breast cancer
... To develop a predictive gene signature score, we com- puted the scalar product of the coefficient of the genes in the signature and the gene expression values (pSTAT3- GS). Fifty-one HER2-positive samples ... See full document
6
HER2 Specific Vaccines for HER2 Positive Breast Cancer Immunotherapy
... Since HER2 has 80% sequence homology to the rat neu gene-coded protein neu, originally detected on rat neuroblastoma cells [13], the proto-oncogene HER2 can thus also be called ...HER2/neu. ... See full document
102
Primary systemic therapy in HER2-positive operable breast cancer using trastuzumab and chemotherapy: efficacy data, cardiotoxicity and long-term follow-up in 142 patients diagnosed from 2005 to 2016 at a single institution
... neoadjuvant therapy in HER2-positive breast cancer with long-term outcomes: a ...Natl Cancer Inst ...neoadjuvant therapy for breast cancer? Crit Rev Oncol ... See full document
114
Clinical outcomes after palbociclib with or without endocrine therapy in postmenopausal women with hormone receptor positive and HER2 negative metastatic breast cancer enrolled in the TREnd trial
... Fig. 3 Bar plot of post-TREnd TTF in patients who received subsequent ET, scaled on a median value. Abbreviations: TTF = time to treatment failure. ET = endocrine therapy. AIs = aromatase inhibitors. mTORi = mTOR ... See full document
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