[PDF] Top 20 um desafio de inclusão para o jornalismo

... the aptamer during transit at neutral pH and the release of DOX at acidic pH are critical to the success of targeted cancer ...the EpCAM aptamer in the circulatory system and tissue ... See full document

... related cell surface marker using an ap- tamer, one can efficaciously deliver siRNA via recep- tor-mediated endocytosis into CSCs in vivo, thus opening a new front for translating RNAi to the on- ... See full document

... with cancer. For colorectal cancer, 5-FU and oxaliplatin are the major chemotherapeutic agents used by oncologists for treating colorectal ...killing cancer stem ...colorectal cancer ... See full document

... thio- aptamer library was intravenously injected to ...with aptamer library-specific ...relevant aptamer (5 ′ -CTACTGGACTTCATCGGAGCTAG- GTCATCGCTTGCATGCA-3 ′ ) was chosen from reference paper as a ... See full document

... and doxorubicin encapsulated in the nanoparticles was determined by disintegrating the nanoparticles and using ultraviolet (UV)–visible spectroscopy to measure paclitaxel (absorbance at 239 nm) or ... See full document

... Figure 3 Thrombin pretreatment promotes the adhesion of MSCs to the culture plastic. A: Aliquots (2 × 10 4 /100 μ l) of MSCs or MSCs were pre-treated with thrombin (4 U/ml) for 24 h were seeded into a 96-well culture ... See full document

... renowned aptamer in anti-cancer research is AS1411, a 26-nucleotide guanosine-rich DNA se- quence discovered by Bates et ...of cancer cells ...tumor cell lines at very low con- centrations, ... See full document

... tumor cell line from primary ...irradiated cell-based vaccines in the clinic ...the cell membrane an immune-modulatory ligand on disaggregated tumor cells obtained directly from the primary tumor ... See full document

... killing cancer cells while minimizing adverse ...and doxorubicin increased activated caspase-8 by promoting pro-caspase-8 homodimerization and autocatalytical cleavage, whereas coadministration did ...while ... See full document

... pancreatic cancer [34, ...pancreatic cancer was carried out and revealed that the addition of OGX-427 to chemotherapy had no improved effect in the first-line setting ...pancreatic cancer, have not ... See full document

... ovarian cancer skov-3 ...the cell uptake efficiency to the basic level for the nontargeting D-NPPP/FITC ...enhanced cell uptake of D-FPPP/FITC was due to the FR-mediated ...improve cell ... See full document

... Due to the lack of early diagnosis and limited therapy options, pancreatic ductal adenocarcinoma (PDAC) is still among the most lethal tumors and is the fourth lead- ing cause of cancer-related deaths in the ... See full document

... When FBP1 was overexpressed, M3 enrichment of lactate was significantly inhibited, and the levels of the glycolytic intermediates F-1,6-BP (M6 species), dihydroxyacetone phosphate (M3 species), and glucose-6-phosphate ... See full document

... lung cancer, like the exo- somes secreted by breast cancer, are also involved in ...lung cancer cells redi- rects lung cancer cells to metastasize to bone ...lung cancer organotropic ... See full document

... inhibited cell stemness, proliferation, and metastasis in ...HCC cell lines such as proliferation and metastasis, however, the exact molecular mechanism remains unclear since the authors only reported the ... See full document

... therapy strategy for breast cancer. However the applica- tion of gene therapy to knock out CD44 still faces various challenges as there are many cells in the human body posi- tive for CD44. Therefore intratumoral ... See full document

... identify cancer-initiating cells, scientists generally separate the tumor cells into various subpopulations using cell surface markers and examine their tumor-forming ability in immunocompromised mice [9, ... See full document

... for cancer of the oral cavity. Clin Cancer Res 2013, 19 (23), 6605-13; (g) Lou, ...neck cancer. British journal of cancer 2004, 91 (3), 441-6; (h) Furuse, ...lung cancer. The Japan Lung ... See full document

... Transmembranprotein. EpCAM wird in Epithellzellen, Krebsstammzellen, Tumorzellen und embryonalen Stammzellen ...sich EpCAM hauptsächlich in baso- lateralen Membranen, wohingegen es auf Krebszellen stark ... See full document

... front of glioma contains abundantly infiltrating TAMs and CD133 + glioma cells in both surgical resections and animal xenografts. These TAMs secrete immunosuppressive factors such as IL-10, and TGF- β 1 in turn polarizes ... See full document