[PDF] Top 20 Una mirada bioética del proceso de globalización.
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Autophagy, selective autophagy, and necroptosis in COPD
... with COPD than in that of control ...in COPD compared to that in healthy ...with necroptosis are relevant to ...and necroptosis during CS ... See full document
12
Histone deacetylase 6–mediated selective autophagy regulates COPD associated cilia dysfunction
... resistant to CS-induced emphysema development (10, 11). Ciliated airway epithelial cells, which provide MCC function, are of crucial importance in airway physiology and pathophysiology (25). MCC acts as a lung defense ... See full document
137
Cell apoptosis, autophagy and necroptosis in osteosarcoma treatment
... of autophagy in the development and progression of osteosarcoma, as well as the response to clinical therapy, remains ...that autophagy can promote both cell survival and cell death ...circumstances, ... See full document
14
Approaching the Molecular Mechanism of Autophagy
... term autophagy reflects cellular self-cannibal- ism, this pathway may also serve a biosynthetic purpose in ...starvation-induced autophagy and pexophagy ... See full document
242
Suppression of astrocytic autophagy by αB crystallin contributes to α synuclein inclusion formation
... astrocytic autophagy regulation is in- volved in neurodegeneration and actively responds to extracellular aggregates ...the selective overexpression of CRYAB in astrocytes re- sulted in the heavier ... See full document
8
Autophagy as an emerging therapy target for ovarian carcinoma
... inducing autophagy, including increased level of MAP LC3, Beclin1, Atg12- Atg5 complex, promotion of transformation of LC3-I to LC3-II and decreased level of p62 ... See full document
6
Autophagy and neurodegeneration
... of autophagy by conditional knockout of the autophagy pro- tein ATG7 in the forebrains of mice results in phospho-tau accumulation in a pattern sim- ilar to a pre-tangle state ...(25). Autophagy has ... See full document
84
TRIP-Br1 oncoprotein inhibits autophagy, apoptosis, and necroptosis under nutrient/serum-deprived condition
... first, autophagy was assessed using two well- known autophagic markers, p62 and ...Finally, necroptosis was examined with the use of the necroptosis marker CypA under same conditions ...for ... See full document
53
Quantitative indices of autophagy activity from minimal models
... The operation mechanism of the process is extremely complex. The three consecu- tive steps, i.e., autophagosome formation, autolysosome formation, and intralysosomal hydrolysis, are operated independently, exhibiting ... See full document
5
Selective Autophagy Regulates Cell Cycle in Cancer Therapy
... overloaded (for example, when the proteasome is blocked), CDK1 interacts with HDAC6 and accumu- lates into aggresomes for later degradation [81]. However, dsRNA-activated protein kinase (PKR) has also been demonstrated ... See full document
30
The signaling involved in autophagy machinery in keratinocytes and therapeutic approaches for skin diseases
... Inhibited autophagy by PAT was also associated with reduced activities of lysosomal enzymes cathepsin ...PAT-inhibited autophagy might contribute to the PAT- induced skin ...carcinogenesis. ... See full document
26
iLIR database : a web resource for LIR motif containing proteins in eukaryotes
... for selective autophagy through their ability to interact with selective autophagy receptor proteins necessary for the specific targeting of substrates for autophagic ... See full document
96
(+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death
... ie, autophagy. A marked activation of the autophagy marker LC3-II was observed after treatment with GF in a concentration-dependent and time-dependent ...GF-induced autophagy mediates the death of ... See full document
13
Original Article Chloroquine sensitizes hepatocellular carcinoma cells to chemotherapy via blocking autophagy and promoting mitochondrial dysfunction
... the autophagy and on the sensitivity of hepatocellular carcinoma cells in vitro, via analyzing the autophagy induction by cisplatin in hepatocellular carcinoma HepG2 cells, via examining the ... See full document
35
Common Traits Spark the Mitophagy/Xenophagy Interplay
... of autophagy regulators include: autophagy-related genes (ATGs) (Itakura and Mizushima, 2010), mechanistic target of rapamycin complexes (mTORC1) (Wong et ...like autophagy activating kinase 1 (ULK1) ... See full document
9
Hypercholesterolemia downregulates autophagy in the rat heart
... Limitations of this study are that the investigation was performed only on male rats, therefore, we cannot ex- clude the possibility that sex influences the effect of hypercholesterolemia on cardiac death and survival ... See full document
14
ATG7 regulates energy metabolism, differentiation and survival of Philadelphia chromosome-positive cells
... mediated autophagy inhibition, CML cells switch from glycoly- sis to mitochondrial respiration, indicating that autophagy plays a role in maintaining the Warburg effect ...of autophagy rather than by ... See full document
205
Paradoxical roles of autophagy in different stages of tumorigenesis: protector for normal or cancer cells
... tremendous autophagy-associated studies have prominently deepened our understanding of the role of autophagy in cancer, there are still so many areas regarding the impact of autophagy on cancer which ... See full document
13
The different roles of selective autophagic protein degradation in mammalian cells
... lysosomes. Autophagy was previously thought to be unselective; however, studies have increasingly confirmed that autophagy- mediated protein degradation is highly ...by autophagy may be beneficial ... See full document
112
Dying to survive apoptosis, necroptosis, autophagy as supreme experiments of nature
... to autophagy, I became interested in the lysosomal path- way of self-destruction back in 2002 or ...that autophagy would be a cell death modality distinct from ...essential autophagy-relevant genes, ... See full document
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