GFN-UCM

GFN GFN - - UCM UCM

Grupo de Física Nuclear

Universidad Complutense de Madrid

Research

Research Lines Lines

• PET

• Instrumentation / new detectors

• Nuclear Physics Experiments

• Radiotherapy

• Radiation Monitoring Equipment

• Jose Udías (PhD in physics, 1993) and Luis M Fraile (PhD in physics, 2000) are associate professors at Complutense University, Madrid.

• •

Experimental Nuclear

Experimental Nuclear Physics Physics

2

CERN: ISOLDE

CERN: ISOLDE

3

•• Particle detectorsParticle detectors •• ScintillatorsScintillators

•• PhotomultipliersPhotomultipliers •• SiPMsSiPMs

•• ElectronicsElectronics

Experimental Nuclear Physics

ISOLDE, JYFL, ILL, ISOLDE, JYFL, ILL, … …

HPGe

LaBr³(Ce) BaF

2

RIB

β ^(NE111A)

stop start

β γ

1

γ

2

T_1/2

Fast timing Fast timing

FATIMA (

FATIMA ( Fast Fast Timing Timing array array

LaBr₃:Ce / CeBr₃ Photosensors Front-end /

timing electronics DAQ - software

Fast Timing Array (FATIMA) for DESPEC Fast Timing Array (FATIMA) for DESPEC

Detectors: LaBr

:Ce

• Doping

• SIZE and SHAPE

• Shielding [Cu-Pb] – Simulations

• CeBr

• Mechanical support

• Simulation – integration Photosensors

• PMs + voltage dividers

• Alternatives

Front-end / timing electronics

• CFDs (ORTEC)

• Digital options DAQ - software

• Multidetector data – acquistion

• Analysis

FATIMA test GSI 2011

FATIMA test GSI 2011

a N25x25

a 1-4-59811

25.4 x 25.4 mm (10%) Ce doping since 2005

123(5) ps FWHM (@1.3 MeV)

38.1 x 38.1 mm 5% Ce doping since 2007

150(10) ps FWHM

FATIMA: LaBr

FATIMA: LaBr 3 3 (Ce) detectors (Ce) detectors

38.1/25.4 x 38.1 mm 5% Ce (2009) Time resolution 140-145 ps FWHM at 1.3 MeV - Tested ISOLDE

30% better for BaF₂

Technology

Technology transfer transfer in in the the following following areas

areas

• PET (SEDECAL, HGGM, UC3M)

• Radiotherapy (GMV Aerospace)

• Radiation Monitoring Equipment (CSN)

PET: overview

SCANNER DESIGN

SCANNER CHARACTERIZATION AND CALIBRATION

DETECTOR DEVELOPMENT

IMAGE RECONSTRUCTION

FBP 2D

OSEM

3D

OSEM

Tools:

Tools:

1.-1.- Our own in house Monte Carlo Our own in house Monte Carlo development

development

(peneloPET ( peneloPET) )

-Very simple to use-Very simple to use

-Comparable speed to the fastest -Comparable speed to the fastest available MC for PET

available MC for PET

-Accurate (validated against -Accurate (validated against

measurements of preclinical and measurements of preclinical and clinical scanners)

clinical scanners) --FlexibleFlexible

-And, what-And, what’’s more important: we s more important: we know it very well

know it very well

2.2.-- Our own set of iterative Our own set of iterative reconstruction algorithms

reconstruction algorithms

(FIRST ( FIRST) )

-Very powerful, use a proprietary -Very powerful, use a proprietary compression scheme (quasi

compression scheme (quasi--

symmetries) to store the SRM in RAM symmetries) to store the SRM in RAM

-Ported to multi-Ported to multi--CPU and GPUCPU and GPU --Fast image updatesFast image updates

INPUTS INPUTS

CPU GPU

70x faster!

Ultrafast reconstructions

• •

11 CONVENTIONAL FIRST

FIRST:

FIRST: licensed licensed to to SEDECAL SEDECAL for for the the Argus

Argus small small animal animal PET PET /CT /CT

• •

<1 mm resolution world class resolution

with scintillator-based PET scanners.

MC based SRM Being used in ~100 research centers world-wide

Collaboration with SEDECAL to develop an improved

small animal scanner (CDTEAM and AMIT consecutive CENIT projects)

DOSE SIMULATIONS DOSE PLANNING

APPLICATOR DESIGN

Intraoperatory

Intraoperatory Radiotherapy Radiotherapy (IORT) (IORT)

MonteCarlo dose calculation incorporated into

Radiance, the FIRST dose planning tool available in IOERT,

worldwide

(developed by GMV Aerospace)

PSE and INNPACTO

projects:

ENTEPRASE, PRECISION and

XIORT

Radiance Surgical planning system (GMV)

Intraoperatory

Intraoperatory Radiotherapy Radiotherapy (IORT) (IORT)

• SCINTILLATOR STUDY

• Measurement of energy resolution,

sensitivity, intrinsic emission (self activity), stopping power

• Test of arrays

• Personal dosimeter station with

spectroscopy capability and remote control and communication, based on SiPM detector

14

LaBr₃(Ce)

TEST OF SCINTILLATORS TEST OF SCINTILLATORS ( ( Grant Grant with with CSN, CSN, the the Spanish Spanish

nuclear

nuclear regulatory regulatory agency agency

Analog SiPM readout >1 GHz bandwith and 40 dB s/n figure

OPAs in non-inverting configuration

Fast and clean pulses

s/n

>40 dB:

Dark current and

137Cs X-rays clearly seen

Right now evaluating timing properties

137

Cs spectra, from SiPM in personal networked dose-meter and spectroscopy

isotope identification station

Project being evaluated by possible commercial partners

Bruker BioSpec 70/20 USR 7 Tesla

LIM – Hospital Gregorio Marañón

Evaluation of

Evaluation of SiPM SiPM Detectors for PET Detectors for PET Imaging with MRI collaboration with Imaging with MRI collaboration with

HGGM and UC3M HGGM and UC3M

2 x 2 SiPM array (6 x 6 mm³) 3600 pixel/element

Pixel size = 50 µm

4 x 4 MLS crystal matrix Crystal size =

1.5 x 1.5 x 12 mm³

18

F

Designed electronics

2 x 2

2 x 2 SiPM SiPM array array - - Results Results

•

F

• 68.2 V - 20ºC

• 5x10

counts

• Software Anger Logic

Peak to valley ratio = 10:1

S España et al.,

NIM A613 (2010) 308

New phoswich arrangement with

Hamamatsu SiPM

Phoswhich separation

0 50 100 150 200 250

0 100 200 300 400 500 600 700 800 900 1000

Counts

Energy (keV)

Factor = 0.065 LuAG:Pr

LYSO

GFN GFN - - UCM UCM

Grupo de Física Nuclear

Universidad Complutense de Madrid

Transfer

Transfer outcome outcome

• About 50% of the funds of the group come from commercial products and technology transfer projects

• Aiming for inmediate translation of detector developments into commercial advantages

• Transfer, for us, is a long range strategy

• In close collaboration with strong partners

such as HGGM, UC3M, UPM, CSN, GMV,

and SEDECAL