[PDF] Top 20 Análise estatística de dados de biologia molecular

... DCM, diabetic cardiomyopathy; ECM, extracellular matrix; FFA, free fatty acid; GAPDH, glyceraldehyde phosphate dehydrogenase; GLUT, glucose transporter; GSK-3β, glycogen synthase kinase-3β; K-ATP, ATP ... See full document

... antioxidant-mediated prevention has been attractive, but hitherto, there was no potential antioxidant found implemented efficiently in clinics [5, ...the diabetic complications in animal models ... See full document

... of diabetic diastolic heart failure, the (mRen-2)27 transgenic rat another study further determined the selective inhibition of PKC- β ...evaluated. Diabetic rats were random- ized to receive either vehicle ... See full document

... these, diabetic cardiomyopathy (DCM) causes the most severe symptoms and is considered to be a major health problem ...the prevention and treatment of many chronic ...the prevention of cardiac ... See full document

... TGF-β, a cytokine important in the pathogene- sis of myocardial fibrosis [19], functions as a profibrotic cytokine and as a growth factor in several pathophysiological processes [20]. TGF-β1 activity, an important factor ... See full document

... The prevention and treatment of diabetic cardiomyopathy are clinically relevant because of its role in the pathogenesis of heart ...on diabetic cardiomyopathy has been studied in only a ... See full document

... CAD. Diabetic cardiomyopathy is believed by many to be a clinical entity with multiple pathogenetic ...of diabetic cardiomyopathy is important as earlier detection may allow earlier ... See full document

... among diabetic patients to improve their knowledge and thus reduce the mortality and morbidity rate caused by peripheral vascular ...the diabetic patients in lifestyle modifications by giving adequate ... See full document

... development of cardiomyopathy: cardiomyocyte-specific deletion of FoxO1 rescued HFD- induced declines in cardiac function and preserved cardiomyocyte insulin responsiveness. FoxO1-depleted cells displayed a shift ... See full document

... in diabetic rats decreased in a time-dependent manner and closely related to the changes of myocardial histopathological ...for diabetic vascular ... See full document

... non-ischemic cardiomyopathy undergoing a CMR study prior to ICD implantation for primary prevention of SCD, we found that scar heterogeneity identified a sub- set of patients who subsequently had ... See full document

... in diabetic hearts is partly attributed to decreased expression of transcription factor PPARα, which is supported by the suppression of PPARα observed in various tissue from animal models and patients with type 2 ... See full document

... Majority of the patients were admitted in NYHA class IV, with extensive pedal oedema and reduced left ventricular systolic function implying a delayed pres- entation. However, 63.3% were discharged home in NYHA class II ... See full document

... Notes: (A) schematic representation of the experimental procedure. Four weeks after operation, OVX diabetic mice were injected with control or clophosome twice a week for 2 weeks to deplete the macrophages. Ten ... See full document

... of branching N-acetylglucosamine and additional sugars, such as galactose, fucose and sialic acid, by Golgi glycosyltransferases to form hybrid and complex N-glycans. It has been reported that the N-linked complex ... See full document

... Background: The role of 1,25-dihydroxyvitamin D3 (vitamin D) in the apoptosis of diabetic cardiomyopathy (DCM) is unclear. This study is to investigate the effects of vitamin D on the pathological changes ... See full document

... Chinese Academy of Medical Sciences (Beijing, China). All mice were housed in same controlled conditions under temperature of 25±1°C and humidity of 55%±5% with 12/12-hour light- dark cycles. The animals were randomly ... See full document

... ventricular cardiomyopathy; BP: Biological processes; CC: Cellular component; DEGs: Differentially expressed genes; DKD: Diabetic kidney disease; DN: Diabetic nephropathy; EMT: Epithelial to ... See full document

... with diabetic cardiomyopathy compared to diabetic Wt ...in diabetic hearts of Hif1a +/− mutants com- pared to diabetic Wt, which may indicate a possible com- pensation for ... See full document

... In a study of well-controlled type II diabetic patients without any evidence of diabetic complications, hypertension, coronary artery disease, congestive heart failure, thyroid or overt [r] ... See full document