[PDF] Top 20 Depressão e atividade física: uma revisão
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Activation of the P2Y2 receptor regulates bone cell function by enhancing ATP release
... osteoblasts treated for 14 days with (C) UTP (≤4-fold) and (D) 2-thioUTP (≤3-fold). (E) Acute treatment with UTP (≥10µM) increased ATP release by ≤4-fold for up to 60 minutes. (F,G,H) No effect of UTP ... See full document
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Important roles of P2Y receptors in the inflammation and cancer of digestive system
... of P2Y2 and P2Y6 receptors in the colonic mucosa of colitic ...of P2Y2 and P2Y6 receptors are increased in both Crohn’s and ulcerative colitis of intestinal human samples compared with noninflamed ...of ... See full document
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The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling
... of bone remodeling and tissue repair associ- ated with aging skeletons and organs likely release ATP, resulting in increased P2RY12 signaling, similar to that occurring in the presence of tumor or ... See full document
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Intracellular Ca2+ release mediated by metabotropic glutamate receptor activation in the leech giant glial cell
... In vertebrate central nervous systems, mGluRs have been shown to be expressed in many cell types, e.g. in hippocampal (Baskys, 1992) or thalamic (Salt and Eaton, 1996) neurones, in neurones of the retina and the ... See full document
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EGFR regulates macrophage activation and function in bacterial infection
... Mreg activation during bacterial infection in vitro and in ...Macrophage activation is critical for defining function, and our studies have established that EGFR assumes a central role in regulating ... See full document
15
Homoharringtonine, a clinically approved anti-leukemia drug, sensitizes tumor cells for TRAIL-induced necroptosis
... any cell death and compared this to the induction of apoptosis by treatment with TRAIL alone (Figure ...induce cell death in these hu- man cancer cells and that sensitizers are ...tumor cell lines ... See full document
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Mutations in known monogenic high bone mass loci only explain a small proportion of high bone mass cases
... Although absolute numbers are small, this remains one of the largest mutationally heterogeneous collections of LRP5 HBM cases to date. Though the severity of the clinical phenotype varied according to the precise ... See full document
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Regulation of the master regulator FOXM1 in cancer
... all function through the same basic ...Gli1 regulates FOXM1 by directly binding to its promoter at BS4 (GCCCACCCA), which contributes to the proliferation of CRC cells ...hepatoma cell invasion and ... See full document
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The P2Y13 receptor regulates extracellular ATP metabolism and the osteogenic response to mechanical loading
... Exogenous ATP (300nM) was hydrolyzed to half the amount within 5 mins in WT osteoblast ...exogenous ATP in P2Y 13 R -/- osteoblasts was slower than WT, with extracellular ... See full document
6
Chronic activation of a designer Gq coupled receptor improves β cell function
... sion and function. The pronounced increase in Irs2 expression in islets from CNO-treated β-Rq mice was the most striking effect that we observed at the transcriptional level (Figure 2B). To determine whether these ... See full document
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Osteoblastic heparan sulfate regulates osteoprotegerin function and bone mass
... in bone formation and ...in bone cell cultures to define the physiological function of endogenous HS in adult ...the function of endogenous ...adult bone is to suppress excessive ... See full document
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Proprotein convertase furin regulates osteocalcin and bone endocrine function
... Finally, we sought to determine more pre- cisely which form(s) of OCN is/are secreted by osteoblasts under normal conditions and when furin-dependent cleavage or γ-carboxylation is inhibited. For that purpose, OCN from ... See full document
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ART3 regulates triple-negative breast cancer cell function via activation of Akt and ERK pathways
... measure cell growth, 20μl of 5mg/ml MTT solution was added into each well of cells with inoculation for 12, 24, 36, 48, and 72 h, and then incubated for ...The cell growth curve was generated with time on ... See full document
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Fibroblast growth factor family as a potential target in the treatment of hepatocellular carcinoma
... its receptor (VEGF receptor 1) in endothelial cells and several other cell ...endothelial cell cultures can induce cellular invasion and capillary-like tubule formation to a greater extent ... See full document
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Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding
... demonstrated that TRPV4 –/– mice manifest an incontinent phenotype but show normal exploratory activity and anxiety-related behavior. Cystometric experiments revealed that TRPV4 –/– mice exhibit a lower frequency of ... See full document
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The CD4 Receptor: An Indispensable Protein in T Cell Activation and A Promising Target for Immunosuppression
... CD4 receptor is the primary entry receptor for the human immunodeficiency ...detrimental function, the CD4 receptor is crucial for positive selection and development of CD4 + T cells as well ... See full document
232
P2X7 receptor signaling contributes to tissue factor–dependent thrombosis in mice
... with ATP continued to increase TF pro- coagulant activity on cells (Supplemental Figure ...modifications. Release of MPs was directly quantified by membrane labeling with the fluorescent dye 6-([N-{7-nitro- ... See full document
168
Stimulation of glia reveals modulation of mammalian spinal motor networks by adenosine
... PAR1 activation would result in a measurable effect on disinhibited bursting if the excitatory neurons underlying this activity were sensitive to modulation by ...glial cell-derived adeno- sine modulates ... See full document
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Schaupp, Andreas (2012): Eph receptor clustering is the central integrator in eliciting graded Kinase-dependent signaling responses. Dissertation, LMU München: Fakultät für Biologie
... Eph receptor/ephrin complexes except for ...1:1 receptor - ligand contact of opposing ...depict receptor/ligand complex formation in panels (E) - ... See full document
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Calcium sensing receptor activation increases cell cell adhesion and ß cell function
... links cell- cell contact to the actin cytoskeleton and various signalling molecules ...of cell-cell contact, connexins (Cx) oligomerise into hexameric hemichannels (connexons) connecting the ... See full document
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