[PDF] Top 20 Enfoques de la educación física en Colombia

... first-step pH response was triggered by the extracellular pH, which switched the surface charge of NPs from negative to positive through the cleavage of DMMA shielding, resulting in enhanced ... See full document

... Herein, pH-responsive, charge-reversal poly(allylamine hydrochlorid)−citraconic anhydride (PAH-cit) functionalized boron nitride nanospheres (BNNS) were fabricated and used as a carrier for the delivery and ... See full document

... redox responsive gene delivery polyplexes, liposomes, micelles, nanoparticles, gels and antibody–drug conjugates[12, 16, ...drug release via well-established intracellular mechanisms, in ... See full document

... DexPHS nanoparticles incorporating doxorubicin had stronger red fluorescence intensity and a higher doxorubicin content in HuCC-T1 cells at an acidic pH whereas free doxorubicin showed ... See full document

... c release was more clearly observed in the cytosol of the SKOV3 cells incubated with Pt(IV) NP-cRGD+US compared with all other ...significantly enhanced the apoptosis in SKOV3 ... See full document

... Results: The optimized DOX–GCPQ nanoformulation was anionic spherical micelles with the hydrodynamic particle size of 97.8±1.5 nm, the PDI of ,0.3, the zeta potential of 28±2 mV, and the encapsulation efficiency of ... See full document

... delayed release of DOX from DOX-loaded micelles within 4 ...the cellular uptake of HA-ss-FA/DOX was mediated by CD44 receptor in CD44 highly expressing cells owing to the CD44-targeting ability of ... See full document

... the enhanced antitumor activity, increased cell apoptosis observed via TUNEL staining assay and reduced systemic toxicity of RDMSNs could probably be involved in the following factors: (1) DOX molecule loaded into ... See full document

... centrifugation. Cellular proteins were determined with 100 µ L cell suspension using the micro-BCA protein- assay ...and cellular protein in collected cell pellets after washing with PBS were determined as ... See full document

... the release profiles of silver ions in the same condition are presented in Figure 3B, Ag-MSNs@CHX showed the similar sustained-release manner of silver ions over a course of 4 days in both acid and neutral ... See full document

... the pH decreased from ...whole pH range, demonstrating the conjugation of Ce6 to the lysine ...the pH-independent singlet oxygen generation of CDTM due to its stable formation over a broad pH ... See full document

... the nanoparticles are presented as supporting information in Table ...The release profile of the doxorubicin-loaded nanoparticles is presented in Figure ...3. Doxorubicin and ... See full document

... selective-killing effect was due to the intrinsic difference between normal and cancer cells. It has been reported that GSH levels in tumor tissues, such as ovarian, head and neck, breast, and lung cancer are higher than ... See full document

... polymeric nanoparticles into the tumor ...lysosomes, pH-responsive polymeric nanomaterials are well developed for drug delivery ...conventional nanoparticles containing pH-sensitive ... See full document

... novel pH- sensitive CS- β -CD derivative by covalently conjugating carboxymethyl- β -CD (CM β -CD) onto the main chains of glycol chitosan ...drug doxorubicin hydrochloride (DOX) was used as a model drug to ... See full document

... higher uptake rates than transferrin-coated, rod-like Au NPs (aspect ratio ...Cell uptake efficiency also decreases as aspect ratio ...lower uptake efficiency than their spherical counterpart for ... See full document

... Nanoparticles for Drug Delivery and Therapy Liposomes were the first generation of NPs used in drug delivery systems followed by emergence of polymeric NPs that are loaded with compounds to mask the surface to ... See full document

... The release of GME from GBM-EC and GME-EC/MC nanoparticles was measured at 37 ° C in 1 × phosphate- buffered saline (PBS) pH ...of release medium (1 × PBS) and then placed in a dialysis bag ... See full document

... delivery, enhanced cellular uptake, and intracellular drug release ...of pH-sensitive cis-aconitic anhydride-modified doxorubicin (DOX-CA) with PMLA afforded the ... See full document

... Initially, stock solutions of CS and HP were prepared at con- centrations of 1 mg/mL in 1 M sodium chloride. The process was carried out at pH 5.6, taking into account the pKa values of CS and HP. A silica ... See full document