[PDF] Top 20 Evaluación del clima organizacional en las entidades prestadoras de salud
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Safety and tolerability considerations in the use of sildenafil for children with pulmonary arterial hypertension
... high-dose sildenafil administered tid for a total of 16 ...ing sildenafil combined versus placebo, with exercise test- ing being performed in all patients able to exercise ...combined sildenafil ... See full document
54
Specific safety and tolerability considerations in the use of anticonvulsant medications in children
... Phenytoin, carbamazepine, phenobarbital, and valproic acid are all widely used older AEDs with narrow therapeutic ranges. Serum levels are well correlated with clinical efficacy and elevated levels are consistently ... See full document
9
Update on pulmonary arterial hypertension in children: management strategies and clinical utility of sildenafil
... Sildenafil has a half-life of approximately 4 hours before metabolism by CYP3A4 and CYTP2C9 of the cytochrome P450 system. However, in pediatrics, this system has two potential major flaws. Firstly, cytochrome ... See full document
6
Bosentan in the treatment of pulmonary arterial hypertension with the focus on the mildly symptomatic patient
... significant safety problems are rare, there are many cautions necessary for their ...The safety of bosentan use in children with PAH has been explored in an open label study which confirmed ... See full document
7
Effects of oral sildenafil on exercise capacity in children with pulmonary arterial hypertension: a randomised trial
... dose sildenafil, three times a ...receive sildenafil in STARTS-1 were main- tained on their initial dose for STARTS-2; those initially receiving placebo in STARTS-1 were randomised to one of the three doses ... See full document
30
Current practices in the use of sildenafil for pulmonary arterial hypertension in Brazilian hospitals
... the use of sildenafil for erectile disfunction in 1998 and PAH treatment in ...small children) require treatment with oral liquid dosage forms that are not frequently ...cutting sildenafil ... See full document
9
Phosphodiesterase-5 inhibitors in management of pulmonary hypertension: Safety, tolerability, and efficacy
... Abstract: Pulmonary arterial hypertension (PAH) is a progressive disease that causes severe disability and has no ...criteria. Sildenafil was the most commonly studied agent, followed by ... See full document
15
<p>Safety and tolerability of macitentan in the management of pulmonary arterial hypertension: an update</p>
... patient tolerability of a direct switch from one agent to the other was ...anorexigen use, 2 had PH following pulmonary thromboendarterectomy for CTEPH, and 2 had portopulmonary ... See full document
12
Safety and tolerability of bosentan in the management of pulmonary arterial hypertension
... in pulmonary arterial hypertension ...of pulmonary vascular disease and plays an important pathogenetic role in the development and progression of ...status, pulmonary hemodynamics, and ... See full document
5
Pulmonary arterial hypertension
... [263-265]. Pulmonary vascular remodelling in different animal models of PAH was shown to regress with the adminis- tration of imatinib mesylate (Gleevec®), a PDGF recep- tors antagonist approved for the treatment ... See full document
261
Platelet derived growth factor receptor β and epidermal growth factor receptor in pulmonary vasculature of systemic sclerosis associated pulmonary arterial hypertension versus idiopathic pulmonary arterial hypertension and pulmonary veno occlusive disease: a case control study
... small pulmonary arteries and plexiform lesions [33]. In pulmonary capillary haemangiomatosis, an entity that shows overlap with both PVOD [42] and SScPAH [19], up-regulation of PDGF-B and PDGFR-ß genes has ... See full document
11
Counter-clockwise vortical blood flow in the main pulmonary artery in a patient with patent ductus arteriosus with pulmonary arterial hypertension: a cardiac magnetic resonance imaging case report
... Pulmonary arterial hypertension (PAH) is a complica- tion in patients with patent ductus arteriosus (PDA), and the retrograde blood flow in the main pulmonary artery caused by left-to-right ... See full document
7
Short Term Drug Drug Interaction between Sildenafil and Bosentan under Long Term Use in Patients with Pulmonary Arterial Hypertension
... in sildenafil concentrations within the same individual was ...in sildenafil concentration, necessitating a great- er number of participants to detect significant differences between treatment ... See full document
8
Regenerative cell therapy for pulmonary arterial hypertension in animal models: a systematic review
... improved pulmonary hemodynamics and RV re- modeling across several ...the use of more comprehensive assessments of cardiac function, particularly the RV functional capacity, as well as follow-up ... See full document
26
The improvement of pulmonary artery pressure after bosentan therapy in patients with β-thalassemia and Doppler-defined pulmonary arterial hypertension
... in patients with intermedia and splenectomized thalassemia increase adherence of RBCs to endothelial cells and throm- boembolism events in multiple organs such as the lungs and pulmonary circulation and, in turn, ... See full document
31
Changes in healthcare utilization and costs associated with sildenafil therapy for pulmonary arterial hypertension: a retrospective cohort study
... the use of other PAH-related medica- tions, such as prostaglandin/prostacyclin analogues ...the use of sildenafil ...of sildenafil therapy must remain ... See full document
8
<p>Management of Pulmonary Arterial Hypertension in Patients with Systemic Sclerosis</p>
... of pulmonary hypertension (PH) that are based on the mechanisms of disease, clinical pre- sentation, hemodynamic characteristics, and therapeutic ...to pulmonary artery obstruction and 5) PH due to ... See full document
19
Clinical profile and outcome of paediatric pulmonary artery hypertension patients
... increased pulmonary vascular resistance causing PAH is loss of vascular luminal cross section due to excessive cell proliferation, reduced rates of apoptosis and vasoconstriction caused by decrease in nitric oxide ... See full document
37
Pulmonary hypertension
... reduce pulmonary artery pressures and did not improve other invasive haemodynamic or clinical parameters in a well characterised cohort of patients with heart failure and preserved ejection fraction and ... See full document
67
The spectrum of pulmonary arterial hypertension in adults with congenital heart disease: management from a physician and nurse specialist perspective
... the pulmonary arteries) but also tendency to bleed (epistaxis, haemoptysis, gastrointestinal bleeds, menorrhagia, ...the use of anticoagulants remains controversial in ES ...in-situ pulmonary artery ... See full document
6
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