[PDF] Top 20 Evidencia 5 ficha tecnica del producto.pdf
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Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation
... the cannabinoid receptor 2 (CB 2 ), as demon- strated by the finding that THC inhibits helper T-cell acti- vation by normal, but not CB 2 knockout-derived, macrophages ...CD40 ... See full document
5
Activation of dorsal horn cannabinoid CB2 receptor suppresses the expression of P2Y12 and P2Y13 receptors in neuropathic pain rats
... 10) were pushed through the intervertebral space until a sudden movement of the tail or the hind limb were ob- served and then passed gently 2 cm upward to reach the level of the lumbar enlargement. The tip of the ... See full document
122
Cannabinoid receptor type-2 stimulation, blockade, and deletion alter the vascular inflammatory responses to traumatic brain injury
... [18,19,22-24,26,27]. Microglial activation and inflammation in the traumatized brain can persist for years after TBI [28,29], and like macrophages, express pro-inflammatory (M1) and anti-inflammatory (M2) ... See full document
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Original Article Activation of cannabinoid receptor type 2 reduces lung ischemia reperfusion injury through PI3K/Akt pathway
... CB 2 agonist markedly decreased the MDA level in infarcted heart [25], which is consistent with our results that activation of CB 2 receptor reduced lung MDA level and ele- vated SOD activity ... See full document
85
Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury
... Next, we examined whether peripheral administration of TC-2559 and another nAChR ligand, sazetidine A, affect neuropathic pain following PSL. On the ipsilateral side, mechanical allodynia defined by the reduction of 50% ... See full document
5
Oncogenic Ras stimulates Eiger/TNF exocytosis to promote growth
... exocyst stimulation vis-à-vis tumor growth. One way in which Ras activation contributes to tumorigenesis is by allowing the cell to evade cell death (Cox and Der, 2003; Downward, 1998; Wolfman et ...sec15 ... See full document
15
The synthetic cannabinoid WIN55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating CB2, TRPV1, TRPA1 and yet unidentified receptor targets
... Synovial tissue samples from OA and RA were obtained immediately after opening the knee joint capsule, the preparation of which was recently described [10]. Pieces of synovial tissue of up to 9 cm 2 were excised. ... See full document
8
Radix Scrophulariae extracts (harpagoside) suppresses hypoxia induced microglial activation and neurotoxicity
... enhances microglial activation and additional IL-1 pro- duction, astrocyte activation, thereby establishing a self- propagating cycle ...stimulates microglial cells to up-regulate their IL-1β ... See full document
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Hypoxia attenuates purinergic P2X receptor-induced inflammatory gene expression in brainstem microglia
... of microglial inflammatory gene expression via P2X purinergic receptor ...P2X receptor activation alone affects inflammatory molecule production in brainstem microglia, nor how hypoxia and P2X ... See full document
5
HDAC2 hyperexpression alters hippocampal neuronal transcription and microglial activity in neuroinflammation-induced cognitive dysfunction
... C57BL/6 male mice (3 months old, weighing 21–25 g) were obtained from Xuzhou Medical University (SYXK 2016-0028). All the mice were housed under standard conditions with four to six mice per cage and were kept in a room ... See full document
16
Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis
... G-coupled receptor 55 (GPR55) was proved to be a receptor of many endocannabinoids ...transient receptor potential vanilloid type-1 and type-4 (TRPV-1, -4) [8,9], and nuclear peroxisome ... See full document
154
Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity
... both cortical and midbrain cultures in our previously published paper and the results showed that they were qualitatively similar [6]. This similarity in Ab-elicited toxicity in both cortical vs. midbrain cultures was ... See full document
7
Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation
... Infarct size was imaged by magnetic resonance imaging (MRI) at 3 days post-injury using a vertical 9.4T Oxford NMR 400 magnet (Oxford Instrument PLC, Abingdon, UK). Mice were anesthetized and maintained at 1.5% ... See full document
139
Activation of cannabinoid receptor type 2 attenuates surgery-induced cognitive impairment in mice through anti-inflammatory activity
... that cannabinoid receptor type 2 (CB2R) can mediate anti-inflammatory and immunomodulatory effects in part by controlling microglial ...of microglial marker CD11b in the CA1 area of the ... See full document
67
Toll-like receptor stimulation increases phagocytosis of Cryptococcus neoformans by microglial cells
... Primary mixed glial cultures were prepared from brains of newborn wild-type C57BL/6 mice (postnatal day 0, p0-p2), or myeloid differentiation factor (MyD)88-deficient mice (p0-p2) with the same genetic background [22]. ... See full document
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Secreted phospholipase A2-IIA-induced a phenotype of activated microglia in BV-2 cells requires epidermal growth factor receptor transactivation and proHB-EGF shedding
... exposed to PrI-labelled apoptotic Jurkat cells for 2 h, and then stained with an anti-PE-CD68 antibody, as described under Methods. (A) Phagocytosis was analyzed by flow cytometry. FL2 fluorescence (left) shows ... See full document
116
Activation of α7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures
... by microglial cells, the largest population of phagocytes associated with the ...Activated microglial cells could cause neu- ronal damage via liberation of free radicals as well as cytokines and toxic ... See full document
265
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
... that cannabinoid antitumoral action may also rely on the inhibition of tumor ...by cannabinoid-treated carcinomas are small, in line with the finding that blood vessel enlarge- ment constitutes a prominent ... See full document
17
Pharmacodynamics of cannabinoids
... psychotropic cannabinoid intake is then associated with opposite effects in the CNS followed by classical withdrawal symptoms such as impaired mood, irritability, anxiety, nausea, and craving after another dose, ... See full document
6
A multiple classifier system identifies novel cannabinoid CB2 receptor ligands
... Limited processing capabilities of computer sys- tems during the 90s led to in silico screening mainly focused on (i) building simple mathematical modelling approaches (often implemented as cellular automatons) for ... See full document
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