[PDF] Top 20 Las fuerzas armadas en américa latina, antes y hoy
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Aromatase inhibitor-associated bone loss and its management with bisphosphonates in patients with breast cancer
... Given the potential anticancer activity of the bisphospho- nates, the Zometa-Femara Adjuvant Synergy Trials included disease-free survival as a secondary endpoint, although the studies were insufficiently powered to ... See full document
22
The present and future role of bisphosphonates in the management of patients with breast cancer
... new bisphosphonates, zoledronic acid and ibandronate, suggest that they may soon find a place in routine ...and bone pain associated with bone metastases [4], and is at least as effective as ... See full document
33
Management of Aromatase Inhibitor-Associated Bone Loss (AIBL) in postmenopausal women with hormone sensitive breast cancer: Joint position statement of the IOF, CABS, ECTS, IEG, ESCEO IMS, and SIOG.
... are associated with high healthcare costs and increased healthcare utilization for several months after fracture incidence [127 – ...and loss of independence, thereby leading to increased indirect ... See full document
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Preventive effect of zoledronic acid on aromatase inhibitor-associated bone loss for postmenopausal breast cancer patients receiving adjuvant letrozole
... 1) patients with clinical or radiological evidence of distant metastases; 2) patients with existing LS or total hip (TH) fracture, or a history of nontraumatic fractures or osteoporosis; 3) patients ... See full document
6
Management of Painful Bone Metastases: The Interaction between Radiation Therapy and Zoledronate
... to bone metastases re- quires a multidisciplinary approach and the radiation therapy is considered a standard treatment used in bone metastases, when there is pain, risk of pathological frac- ture, and ... See full document
161
Bone loss and the aromatase inhibitors
... steroidal aromatase inhibitor, which is also superior to megestrol acetate (Kaufmann et al, ...first cancer-related events, disease-free survival and contralateral breast cancer were ... See full document
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Aromatase inhibitor associated bone and musculoskeletal effects: new evidence defining etiology and strategies for management
... the Breast International Group (BIG) 1-98 trial, which directly compared 5 years of adjuvant tamoxifen with 5 years of letrozole, the fracture rate was signifi cantly higher in the letrozole group ...in ... See full document
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Impact of aromatase inhibitor treatment on global gene expression and its association with antiproliferative response in ER+ breast cancer in postmenopausal patients
... were associated with poor antiproliferative response when Ki67 change was dichotomised [12, ...being associated with AI resistance, there was no significant association between Inflammatory-GS and the ... See full document
10
Denosumab, a RANK ligand inhibitor, for the management of bone loss in cancer patients
... for management of osteoporosis and is significantly less than the dose used for treatment of metastatic bone dis- ease (120 mg subcutaneously every 4 ...spine bone mineral density at 12 ...stage ... See full document
17
Mechanisms of endocrine resistance in breast cancer: an overview of the proposed roles of noncoding RNA
... prostate cancer associated noncoding RNA 1 (PRNCR1) and prostate-specific tran- script 1 (PCGEM1) have previously been reported to play a role in transcription of androgen receptor target genes in the ... See full document
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Impact of aromatase inhibitor treatment on global gene expression and its association with antiproliferative response in ER+ breast cancer in postmenopausal patients.
... ER+ breast cancer cells and in patients' ER+ tumors [12]; GDNF- GS, a proliferation-independent GDNF response signature reported to be prognostic of poor patient outcome and poor response to AI ... See full document
5
Molecular response to aromatase inhibitor treatment in primary breast cancer
... commonly associated with the functions of stromal compo- nents than of epithelial cells (VIM, CTGF, FN1, and ...in cancer cells in breast can- cers but in fibroblasts, and it is associated ... See full document
11
Prospective analysis of favorable prognostic factors in carcinoma breast
... carcinoma breast is a systemic disease since its appearance and by the time tumor has grown to 1 cm size it would have metastasised and it is thought that occult metastasis is already present with operable ... See full document
21
Critical appraisal of denosumab in the treatment and prevention of postmenopausal osteoporosis and bone loss in patients undergoing hormone ablation
... treating patients with excessively high rates of bone ...decreases bone resorption and increases bone mineral density (BMD) at the lumbar spine, total hip, femoral neck, and one-third radius ... See full document
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Loss of constitutive <em>ABCB1</em> expression in breast cancer associated with worse prognosis
... recruited patients, collected clinical and histopatho- logical data, characterized genotypes and haplotypes, helped evaluating patients’ blocks and slides, conducted immuno- histochemical and mRNA ... See full document
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The role of bisphosphonates in breast cancer: Actions of bisphosphonates in animal models of breast cancer
... osteoblastic bone metastases The estrogen receptor positive human breast cancer cell line, MCF-7, has been shown to produce osteoblastic or mixed osteolytic and osteoblastic bone lesions ... See full document
22
The impact of an exercise program on quality of life in older breast cancer survivors undergoing aromatase inhibitor therapy: a randomized controlled trial
... postmenopausal breast cancer survivors, undergoing AI treatment, in early breast cancer stages ...postmenopausal breast cancer survivors taking AI and the study outcomes suggest ... See full document
22
The role of bisphosphonates in breast cancer: Direct effects of bisphosphonates on breast cancer cells
... with bisphosphonates leads to growth inhibition and induction of apoptosis ...human breast cancer cell lines was seen, together with morphological and biochemical changes consistent with ...different ... See full document
18
Circulating ESR1 mutations at the end of aromatase inhibitor adjuvant treatment and after relapse in breast cancer patients
... 38 patients (90%) of the full ...(74%) patients, including 21 treated with AI ...(33%) patients progressing on AI while none of the ten patients progressing on chemotherapy or non-AI endocrine ... See full document
11
Breast cancer metastasis to the bone: mechanisms of bone loss
... for bone metastasis is ...once bone metastasis has occur- red, the aim has been to break the osteolytic cycle by targeting ...metastatic bone disease [71]. Th ese molecules bind to hydroxyapatite of ... See full document
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