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Enhanced dissolution and solubility of Epalrestat with β-Cyclodextrin ternary complex using Arginine
... The molecular interaction between EPL and β-CD was revealed by FTIR. Fig.3 shows the FTIR spectra of binary and ternary complex. For EPL, principle absorption peaks were found near to 1742, 1673, and ... See full document
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AMELIORATED SOLUBILITY AND DISSOLUTION RATE OF GLIMEPIRIDE BY CYCLODEXTRIN TERNARY COMPLEXES EMPLOYING AMINOACIDS
... aqueous solubility and dissolution rate of an anti diabetic drug Glimepiride by cyclodextrin ternary complexes employing ...with β-Cyclodextrin (βCD) and Hydroxy propyl β- ... See full document
25
DESIGN AND DEVELOPMENT OF ORAL DISINTEGRATING TABLET OF SIMVASTATIN BY USING β CYCLODEXTRIN
... by using β-cyclodextrin with direct compression technique using various superdisintegrants like Crosprovidone, Croscaramellose sodium and Lactose and Mannitol as ...of dissolution. ... See full document
17
Enhanced Dissolution and In-Vivo Biavailability of Itraconazole Cyclodextrin Complex.
... inclusion complex powders were observed to consist of agglomerates of very fine (100–500 nm) ...inclusion complex. Furthermore, the ASES-processed ITR/HP-β-CD powders showed a significant enhancement ... See full document
2
ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF TELMISARTAN EMPLOYING β-CYCLODEXTRIN AND SOLUPLUS – A FACTORIAL STUDYN.Tirumalesh and K. P. R. Chowdary* DOWNLOAD/VIEW
... the solubility of ...the solubility of Telmisartan, ...The dissolution of Telmisartan was rapid and higher in the case of Telmisartan - βCD complex systems when compared to Telmisartan pure ... See full document
24
Inclusion Complex of alpha-Lipoic Acid Containing Alkalizer for Improving the Solubility and Stability Prepared by Co-grinding
... inclusion complex was prepared by co-grinding α-lipoic acid with hydroxypropyl-β-cyclodextrin and alkalizer to enhance the solubility and stability of α-lipoic ...hydroxypropyl- ... See full document
15
Nanoparticle Formation of Puerarin-beta-Cyclodextrin Inclusion Complex Using SEDS: Dissolution Enhancement
... water solubility of ...of β-CD evidently had a positive effect because the untreated physical mixture exhibited higher dissolution rates than the untreated ...The dissolution of ICNP ... See full document
12
MELOXICAM PECTIN β CYCLODEXTRIN TERNARY COMPLEX BY KNEADING FOR ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE
... solid complex and ternary solid complexes was determined using a previously reported method ...solid complex, ternary complex with agar, and ternary complex with ... See full document
13
EVALUATION OF DIURETIC ACTIVITY OF HYDROCHLOROTHIAZIDE ? CYCLODEXTRIN INCLUSION COMPLEX IN WISTAR RATS
... HCT-γ-CD complex (10mg/100gBW) produced a notable and highly significant increase in urinary excretion of 41% (p < ...inclusion complex has a high conductivity which statistically significant ...γCD ... See full document
143
Dissolution enhancement of pioglitazone hydrochloride using β- cyclodextrin
... Method: Using a suitable adhesive, the base of a 10 ml tarred measuring cylinder is fixed to the standard rubber bung at the top of the 250 ml cylinder. A powder sample (about 5.0 g) is transferred into the tarred ... See full document
13
HYDROXYPROPYL β -CYCLODEXTRIN INCLUSION COMPLEX OF CURCUMIN USING FLUORESCENCE LIFETIME MEASUREMENT.
... Although safe in most cases, ancient treatments are ignored neither their active components nor their molecular targets are well defined. This is not the case, however, with curcumin, a yellow pigment substance and ... See full document
23
Preparation, Characterization and in vitro Evaluation of Tosufloxacin Tosylate and Hydroxypropyl-beta-cyclodextrin Inclusion Complex
... on dissolution. It can be seen that the dissolution curves are quite ...the dissolution also increased. The dissolution was highest when the ratio of host to guest was 2:1, but increasing the ... See full document
241
Effect of Cyclodextrin Complexation on the Aqueous Solubility of Diazepam and Nitrazepam: Phase Solubility Analysis, Thermodynamic Properties
... (w/w) (solubility more them 50%). The solubility of β-cyclodextrin in water about at room temperature. The diazepam/nitrazepam powder was added (Analytical balance type XS 205, Mettler Toledo ... See full document
34
ENHANCEMENT OF DISSOLUTION RATE AND SOLUBILITY OF LOSARTAN POTASSIUM BY USING SOLID DISPERSION METHOD β CYCLODEXTRIN AS CARRIER
... Losartan and β-cyclodextrin were obtained as a gift sample from Natco labs Hyderabad. Magnesium stearate and sodium starch glycolate were obtained from SD fine chemicals, talc was obtained from merck ... See full document
88
Physicochemical investigation of the influence of saccharide-based parenteral formulation excipients on l-p-boronphenylalanine solubilisation for boron neutron capture therapy
... A proposed Cancer Research UK sponsored trial of BNCT in malignant glioma required a BPA formulation that could be prepared to GMP standards to meet European Union Clinical Trials Directive requirements. In addition the ... See full document
45
CYCLODEXTRINS: VERSATILE CARRIER IN DRUG FORMULATIONS AND DELIVERY SYSTEMS
... described Cyclodextrin as enzyme conversion product of ...the cyclodextrin chemistry in ...first cyclodextrin-related patent was issued in 1953 to Freudenberg, Cramer and ...Plieninger. ... See full document
8
A FACTORIAL STUDY ON ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF LORNOXICAM EMPLOYING HP β CYCLODEXTRIN AND SURFACTANTS
... is dissolution rate limited and it requires enhancement in solubility and dissolution rate for increasing its oral ...the solubility and dissolution rate of lornoxicam employing Hydroxy ... See full document
5
Nanosuspension versus cyclodextrin inclusion of ciprofloxacin for solubility and dissolution enhancement
... For solubility study, samples containing equivalent amount of ciprofloxacin were suspended in distilled water and placed in biological shaker at 37°C 72 ...For dissolution profile, equivalent amount of ... See full document
50
ENHANCEMENT OF SOLUBILITY OF EFAVIRENZ EMPLOYING β -CYCLODEXTRIN, POLOXAMER 407 AND PVP K30: PHASE SOLUBILITY AND FACTORIAL STUDIES
... with β cyclodextrin (βCD) and use of Poloxamer 407 and PVP K30 were tried to enhance the solubility of ...the solubility of efavirenz were investigated by phase solubility studies in ... See full document
5
Changes in the intestinal absorption mechanism of icariin in the nanocavities of cyclodextrins
... China). β -CD (molecular mass, 1135) was kindly donated by Maxdragon International Co (Guangzhou, ...HP- β -CD (molecular mass, 1540) was purchased from Wacker Chemie AG (Munich, ... See full document
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