[PDF] Top 20 La Internacionalización del Sector Bancario Europeo
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POLYMER -LIPID HYBRID NANOPARTICLES FOR BRAIN TARGETING THROUGH INTRANASAL DELIVERY
... chitosan polymer and lipid in same ...hydrophilic polymer chitosan, this expression tells that drug release follows Korsmeyer model with non-Fickian diffusion super class II ...glassy polymer ... See full document
262
In situ gel for nasal drug delivery
... gelling polymer and HPMC and xanthan gum as mucoadhesive ...in brain targeting were assessed in rats following intranasal administration of 99mTc-ropinorole in situ ...an intranasal ... See full document
8
Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of Alzheimer’s disease
... for intranasal administration of HupA-loaded PLGA, TMC, and Lf-TMC ...the brain and blood were calculated separately. The drug targeting index (DTI) was calculated to evaluate ... See full document
15
iRGD-modified lipid–polymer hybrid nanoparticles loaded with isoliquiritigenin to enhance anti-breast cancer effect and tumor-targeting ability
... cancer targeting and stronger targeting ...The targeting ability of ISL-iRGD NPs was detected in vivo and in ...new delivery system for encapsulating ISL was effective and can promote the ... See full document
11
Solid Lipid Nanoparticles for Brain Targeting
... drug delivery in form of emulsions, fail to overcome these obstacles, and hence there is a need for newer drug delivery approach, that will cross these barriers of the ...these nanoparticles can be ... See full document
15
Folate-modified lipid–polymer hybrid nanoparticles for targeted paclitaxel delivery
... The internalization of Nile Red-loaded NPs incubated for 2 hours was visualized by CLSM. To precisely observe the cellular distributions of NPs, we performed triple fluores- cence-labeling experiments and visualized red ... See full document
6
Design and Characterization of Intranasal Brain Targeted Delivery of Almotriptan Malate Loaded Biodegradable Nanoparticles for Migraine
... Solid lipid nanoparticles comprise of lipids that are in solid phase at room temperature and surfactants for ...stabilize lipid dispersion, including soybean lecithin, phosphatidylcholine, poloxamer ... See full document
5
Polymer–lipid hybrid anti-HER2 nanoparticles for targeted salinomycin delivery to HER2-positive breast cancer stem cells and cancer cells
... the targeting efficacy of Sali-NP-HER2 in HER2-overexpressing breast CSCs and cancer ...the targeting efficacy but not the intrinsic activity of the conjugated HER2 ...blank polymer–lipid ... See full document
6
Intranasal agomelatine solid lipid nanoparticles to enhance brain delivery: formulation, optimization and in vivo pharmacokinetics
... achieving brain targeting by this ...drug delivery to the brain with the intranasal SLN-14 compared with the systemic ...favored brain drug delivery can be related to the ... See full document
24
MRI-guided targeting delivery of doxorubicin with reduction-responsive lipid-polymer hybrid nanoparticles
... the polymer of PLGA (40 mg) was added to the solution and stirred at room temperature for 2 ...and lipid lecithin (weight ratio 1/6/6/2, total weight 30 mg) were dissolved in 30 mL of 4 wt % ethanol aqueous ... See full document
5
FORMULATION AND EVALUATION OF NOVEL BRAIN TARGETING DRUG LOADED IN LIPID-BASED NANOPARTICLES THROUGH INTRANASAL ROUTE FOR ALZHEIMER
... different lipid- based drug delivery systems (Niosomes) loaded with rivastigmine tartarate is used to solve the problem of the extensive rapid metabolism of ...Prepared nanoparticles were ... See full document
34
Influence of cationic lipid concentration on properties of lipid–polymer hybrid nanospheres for gene delivery
... the lipid con- centration was increased from 6% to 24% ...and lipid assembly further, two different fluorescent dyes – NBD-PC ...the lipid– polymer core–shell structure by forming a uniform ... See full document
15
DESIGN, OPTIMIZATION AND CHARACTERIZATION OF LAMIVUDINE LOADED SOLID LIPID NANOPARTICLES FOR TARGETED DELIVERY TO BRAIN
... equivalent of LMV SLNs were separately dispersed in 4 ml of phosphate buffer pH 7.4. The resulting dispersion was put in the dialysis bag (MWCO 13000-14000 Da, HiMedia, India) and was dialyzed separately against 150 ml ... See full document
29
NANOCARRIER FOR INTRANASAL ADMINISTRATION
... the intranasal administration, about 30 min after operation, 100 µl of the nasal formulation was administered via a PE 10 tube attached to a microlitre syringe inserted 1 cm into each nostril of rat at a dose of 4 ... See full document
73
Journal of Applied Pharmaceutical Science
... In the recent years, there are many studies showed that the use of nanotechnology in the development of novel drug delivery systems could enhance the efficacy and alleviate the severe side effects accompanied with ... See full document
10
Lipid Polymer Based Nanoparticles As A New Generation Therapeutic Delivery Platform For Ulcerative Colitis In Vitro/In Vivo Evaluation
... Toward the finish of the fifth hour, the medium was degassed utilizing nitrogen gas to evacuate undissolved oxygen to keep up anaerobic conditions inside the vehicle for 15 minutes. Rodent cecal arrangement newly ... See full document
16
Formulation and targeting efficiency of cisplatin engineered solid lipid nanoparticles
... average targeting efÞ ciency of drug loaded SLN was found to be ...in brain, whereas accumulation of pure drug was ...in brain of the injected ...solid lipid nanoparticles showed ... See full document
6
GLIOBLASTOMA MULTIFORME: A REVIEW OF ITS PATHOGENESIS AND TREATMENT
... commonly affected by glioblastoma multiforme, with an incidence rate of almost 1.6 times higher than in females.GBM can take place at any age however, the peak incidence is between 55 to 74 years. Anaplastic astrocytomas ... See full document
13
<p>A multifunctional-targeted nanoagent for dual-mode image-guided therapeutic effects on ovarian cancer cells</p>
... The optical microscopy images (Figure 1B) of TOI_HNPs before irradiation showed that NP was a uniform spherical shape and nanoscale. It was found that particles enlarged by ODV principles after 808 nm laser irradiation ... See full document
5
In vitro performance of lipid PLGA hybrid nanoparticles as an antigen delivery system: lipid composition matters
... PLGA-KLH nanocomplex was prepared using double emulsion solvent evaporation method [13]. Briefly, PLGA of 200 mg was dissolved in 5 mL dichloromethane, followed by mixing with 300 μL of 10 mg/mL KLH using a vortex mixer ... See full document
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