[PDF] Top 20 Memoria y violencia en el cine colombiano
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c-FLIP is involved in tumor progression of peripheral T-cell lymphoma and targeted by histone deacetylase inhibitors
... HDACI-mediated c-FLIP downregulation was related to NF- κ B inactivation via interrupting p50 interaction with c-FLIP c-FLIP is a target gene of NF-κB ...gene ... See full document
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BELINOSTAT: A HISTONE DEACETYLASE INHIBITOR FOR THE TREATMENT OF PATIENTS WITH RELAPSED OR REFRACTORY PERIPHERAL T CELL LYMPHOMA
... ABSTRACT: Histone deacetylase inhibitors (HDACIs) are a group of agents that have exhibited antitumor activity in vivo and in vitro, directing to clinical trials estimating their efficacy in multiple ... See full document
9
Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy
... FDA-approved inhibitors are the pan-HDACi vorinostat (aka suberoylanilide hydroxamic acid [SAHA]), which is available as an oral medication, and the class I HDACi romidepsin (a bacterial cyclic peptide), which is ... See full document
7
Histone deacetylase enzymes and selective histone deacetylase inhibitors for antitumor effects and enhancement of antitumor immunity in glioblastoma
... HDAC inhibitors, this method may give some idea to which HDAC enzymes are aberrantly expressed in these ...in tumor samples but the response of the tumor to a HDAC inhibitor as a potential therapy is ... See full document
6
Therapeutic options in peripheral T cell lymphoma
... Alemtuzumab Alemtuzumab is an anti-CD52 monoclo- nal antibody that is known to suppress immunity, includ- ing the depletion of CD4 and CD8 T cells as well as B cells. It has undergone early stage evaluation, but ... See full document
15
An update on the management of peripheral T-cell lymphoma and emerging treatment options
... Treatment consisted of 6–8 cycles of CHOP or etoposide plus CHOP (CHOEP). Three-year event-free survival (EFS) and OS was 75.8% and 89.8% (ALK-positive ALCL), 50.0% and 67.5% (AITL), 45.7% and 62.1% (ALK-negative ALCL), ... See full document
5
Histone Deacetylase Inhibitors As Potential Therapeutic Agents For Various Disorders
... is targeted by HATs enzyme is collectively termed as FATs (Factor acetyltransferases) including p53, E2F, and GATA1 9 (GATA-binding factor 1) (Roth et al , ... See full document
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Chidamide in the treatment of peripheral T-cell lymphoma
... mature T-cell lymphomas, the most common subtypes include peripheral T-cell lymphoma, not otherwise specified, angioimmunoblastic T-cell lymphoma (AITL), and ... See full document
24
Histone Deacetylase Inhibitors Delivery using Nanoparticles with Intrinsic Passive Tumor Targeting Properties for Tumor Therapy
... compound 2) at 25 °C. The chemical shift scale expressed in ppm was calibrated on the basis of the deuterated solvent or tetramethylsilane as reference. For compounds 4 peak assignments was made with DEPT135, COSY ... See full document
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Interpreting clinical assays for histone deacetylase inhibitors
... the cell nucleus, the genome is packaged into a superstructure, the chromatin, whose elementary dynamic units are the ...linker histone H1 (Figure ...1 Histone acetyltransferases (HATs), for ... See full document
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Activity of histone deacetylase inhibitors and an Aurora kinase inhibitor in BCR-ABL-expressing leukemia cells: Combination of HDAC and Aurora inhibitors in BCR-ABL-expressing cells
... of HDAC proteins (Figure 2A). As such, our data indicated that vorinostat or pracinostat and tozasertib affected the activities of both Aurora kinase and HDAC, in turn in- creasing antitumor activity in this system. ... See full document
20
Histone acetylation: novel target for the treatment of acute lymphoblastic leukemia
... of inhibitors, chemically classified as short- chain fatty acids and hydroxamic acids, ...ALL cell lines including Sup-B15, TMD-5, SEM, and NALM-6 ...doxorubicin-resistant T-ALL and a relapsed infant ... See full document
19
Epigenetic activities of flavonoids in the prevention and treatment of cancer
... DNMT inhibitors (DNMTi) are already in clinical use or currently under investigation in clinical ...non-nucleoside inhibitors [62, ...nucleoside inhibitors are their cytotoxicity (especially ... See full document
26
Epigenetic Regulation of Glucose Transporters in Non Small Cell Lung Cancer
... We have demonstrated the induction of both Glut-3 and Glut-4 in NSCLC cell lines in response to HDAC inhibition. Glut-3 generally considered to be confined to tissues that exhibit a high glucose demand [38], while ... See full document
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Original Article Clinical characteristics, prognostic factors, and histone deacetylase 6 expression in primary gastric diffuse large B-cell lymphoma
... lymphoma [24-29]. Current results were simi- lar, indicating that B-symptoms, elevated LDH, decreased albumin, poor PS (ECOG ≥ 2), high IPI scores (≥ 3), and advanced stages (IV) were associated with poor OS and ... See full document
149
<p>Identification of hub genes and key pathways associated with angioimmunoblastic T-cell lymphoma using weighted gene co-expression network analysis</p>
... dependent cell adhesion molecule that is essential for maintaining the integrity of cell-cell ...fi c immune responses, and other cellular interactions important for immune response and ...or ... See full document
14
Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption
... chondrocyte cell lines ...HDAC inhibitors to cartilage explant cultures blocks IL-1/OSM- induced cartilage catabolism with a decrease in collagenolytic activity in the conditioned culture ...HDAC ... See full document
20
Romidepsin: evidence for its potential use to manage previously treated cutaneous T cell lymphoma
... that T wave and ST seg- ment abnormalities and QT interval prolongation were earlier findings associated with histone deacetylase inhibitor ...(QT c ) or interfere with cytochrome (CYP)3A4 ... See full document
9
<p>The Synergistic Antitumor Activity of Chidamide in Combination with Bortezomib on Gastric Cancer</p>
... NSCLC cell death by means of inhibiting NF- κ B ...myeloma cell lines through disturbing the bone marrow microenvironment and inducing caspase-dependent ...HDAC-mediated histone acetylation in the ... See full document
5
Trends in the treatment of cutaneous T-cell lymphoma – critical evaluation and perspectives on vorinostat
... from progression of disease and cumulative adverse effects from multiple treatments, development of novel therapies with better therapeutic indices and more durable remissions is ... See full document
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