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Current approaches to incorporation of radium-223 in clinical practice.
... practices, radium-223 is generally used early in the management of the disease if the patient exhibits sympto- matic bone metastases with or without small volume pelvic or retroperitoneal lymph node ... See full document
38
The safety and efficacy of radium-223 dichloride for the treatment of advanced prostate cancer.
... of radium- 223 with placebo in men with CRPC and bone metastases ...of radium-223 and best supportive care (BSC) or placebo and BSC every 4 weeks to a total of six ...and current ... See full document
66
Evolving treatment approaches for the management of metastatic castration-resistant prostate cancer – role of radium-223
... with radium-223 as a single agent or in combination with other systemic ...outside clinical trials. Another question is the use of radium-223 in patients with both bone and visceral ... See full document
9
Hematologic Safety of Radium-223 Dichloride: Baseline Prognostic Factors Associated With Myelosuppression in the ALSYMPCA Trial.
... of radium-223 injections received, it is important to note that patients were supported with transfusions as needed and as described in the prescribing ...with radium-223 and placebo and ... See full document
48
Development of sodium fluoride PET response criteria for solid tumours (NAFCIST) in a clinical trial of radium-223 in osteosarcoma: from RECIST to PERCIST to NAFCIST
... On the basis of the preliminary data presented in the current study, we propose NAFCIST criteria (table 3). NAFCIST could supplant PET/CT functional response by adding metabolic response criteria for bone-forming ... See full document
173
Effect of radium-223 dichloride (Ra-223) on hospitalisation: An analysis from the phase 3 randomised Alpharadin in Symptomatic Prostate Cancer Patients (ALSYMPCA) trial.
... of radium-223 on SSEs and the influence of skeletal com- plications on HCRU, we further explored the impact of radium-223 on hospitalisation days before first SSE and after SSE to determine ... See full document
6
Efficacy and Safety of Radium-223 Dichloride in Symptomatic Castration-resistant Prostate Cancer Patients With or Without Baseline Opioid Use From the Phase 3 ALSYMPCA Trial.
... of radium-223 patients and 45% of placebo patients were minimally symptomatic, with no pain or mild pain and no opioid use; of these, 4% of radium-223 patients and 1% of placebo patients were ... See full document
11
Can bone scans guide therapy with radium-223 dichloride for prostate cancer bone metastases?
... the superior role of Gallium 68 prostate-specific membrane antigen (Ga 68 PSMA) positron electron tomography (PET) in the evaluation of patient suitability for Ra-223 therapy over bone scan. Many of the patients ... See full document
36
Pain response in a population based study of radium 223 (Ra223) for metastatic castration resistant prostate cancer
... Introduction: Clinical trials have shown that radium-223 (Ra223) can prolong survival and improve quality of life in patients with metastatic castration-resistant prostate cancer ... See full document
9
Hematologic Safety of Radium-223 Dichloride: Baseline Prognostic Factors Associated With Myelosuppression in the ALSYMPCA Trial.
... in radium-223 patients, and risk increased with prior docetaxel and decreased baseline he- moglobin and ...among radium-223 patients previously exposed to docetaxel versus those not exposed ... See full document
38
Pain response in a population based study of radium 223 (Ra223) for metastatic castration resistant prostate cancer
... 1,5 Clinical trials patients tend to have more favorable outcomes than those treated in non-trial settings, often due to the rigorous eligibility criteria that have to be ... See full document
15
‘Trial and error…’, ‘…happy patients’ and ‘…an old toy in the cupboard’: a qualitative investigation of factors that influence practitioners in their prescription of foot orthoses
... of current practice and given the variation in practice and influencing factors involved, a wider exercise seems per- ...orthotic practice and allow associations to spe- cific issues to be ... See full document
20
‘Trial and error…’, ‘…happy patients’ and ‘…an old toy in the cupboard’: a qualitative investigation of factors that influence practitioners in their prescription of foot orthoses
... orthotic practice [8, 9] since this was likely to be the foundation for their initial ...Alternative approaches to foot assessment, such as the Foot Posture Index [11] might also inform clinical ... See full document
32
Current Molecular Imaging of Spinal Tumors in Clinical Practice
... Evaluation of the spinal cord with PET is, in part, limited by scanner spatial reso- lution, with compromised sensitivity for the detection of hypermetabolic lesions smaller in size than approximately 2.5 times the ... See full document
7
A phase IIa, nonrandomized study of radium-223 dichloride in advanced breast cancer patients with bone-dominant disease
... that radium-223 increased survival and decreased bio- chemical markers of bone metabolism ...study, radium-223 consistently reduced uNTX-1 and bALP levels during the 16-week treatment period ... See full document
21
An exploratory analysis of alkaline phosphatase, lactate dehydrogenase, and prostate-specific antigen dynamics in the phase 3 ALSYMPCA trial with radium-223.
... established radium-223 efficacy and safety in CRPC patients with bone metastases [18, ...With radium-223, versus placebo, OS improved significantly (median ...favored radium-223 ... See full document
10
REVISITING THE ROLE OF PHYCOCYANIN IN CURRENT CLINICAL PRACTICE
... of current practice, antioxidant properties of phycocyanin have been investigated for their anti-inflammatory, anti- proliferative and anti-cancer ... See full document
21
APPLICATION OF ‘TRIVIDHA PARIKSHA IN CURRENT CLINICAL PRACTICE .......
... The word ‘darshana’ means inspection, observation. In Ayurveda clinical examination begins as soon as patient steps in the consultation room. Physician should have best observation skill to master in this ... See full document
7
Radium-223 chloride: a potential new treatment for castration-resistant prostate cancer patients with metastatic bone disease
... Serum alkaline phosphatase decreased in both groups of patients, but was greatest in the patients with prostate cancer ( − 52.1 ± 14.8, mean ± standard deviation) and significantly different between the groups (P = ... See full document
17
Pain predicts overall survival in men with metastatic castration-resistant prostate cancer treated with radium-223
... retrospective study was OS, defined as the time from the initiation of radium-223 to the date of death, regardless of cause. Secondary end points included the percentage of patients with an ALP reduction ... See full document
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